PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30181440-2	2018	AVCRI104P3 is a huprine derivative that exhibits potent inhibitory effects on human AChE, BuChE, and BACE-1 activities, as well as on AChE-induced and self-induced Abeta aggregation.	huprine	16-23	beta-secretase 1	Homo sapiens	101-107	
26502813-2	2016	Two novel enantiopure rhein-huprine hybrids ((+)-1 and (-)-1) exhibit potent inhibitory effects against human acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), BACE-1 and both Abeta and tau antiaggregation activity in vitro and reduction on the amyloid precursor protein (APP) processing in vivo.	huprine	28-35	beta-secretase 1	Homo sapiens	170-176