PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16002382-2 2005 Organophosphorus insecticides (OPs) target the developing nervous system, and until recently, the most common residential insecticides were chlorpyrifos and diazinon, two OPs metabolized in the body through the cytochrome P450/paraoxonase 1 (PON1) pathway. Diazinon 157-165 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 211-240 15764407-0 2004 Biotransformation of chlorpyrifos and diazinon by human liver microsomes and recombinant human cytochrome P450s (CYP). Diazinon 38-46 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 113-116 15764407-1 2004 The cytochrome P450 (CYP)-mediated biotransformation of the organophosphorothioate insecticides chlorpyrifos and diazinon was investigated. Diazinon 113-121 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 4-19 15764407-1 2004 The cytochrome P450 (CYP)-mediated biotransformation of the organophosphorothioate insecticides chlorpyrifos and diazinon was investigated. Diazinon 113-121 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 21-24 15764407-9 2004 However, the role of individual CYP enzymes in these two biotransformation pathways varied according to the structure of the organophosphorothioate, which was reflected in different activation/detoxification ratios for chlorpyrifos and diazinon. Diazinon 236-244 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 32-35 15764407-10 2004 Variability in activity of individual CYP enzymes may influence interindividual sensitivity to the toxic effects of chlorpyrifos and diazinon. Diazinon 133-141 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 38-41 4371680-0 1974 Spectral and catalytic properties of cytochrome P-450 from a diazinon-resistant housefly strain. Diazinon 61-69 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 37-53