PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26969385-0 2016 beta-carotene reverses multidrug resistant cancer cells by selectively modulating human P-glycoprotein function. beta Carotene 0-13 ATP binding cassette subfamily B member 1 Homo sapiens 88-102 26969385-6 2016 The underlying molecular mechanisms and inhibitory kinetics of beta-carotene on the major ABC efflux transporter, P-glycoprotein, were further investigated. beta Carotene 63-76 ATP binding cassette subfamily B member 1 Homo sapiens 114-128 26969385-16 2016 The combination of beta-carotene and chemotherapeutic agents significantly potentiated their cytotoxicity in both cell stably expressed human P-gp (ABCB1/Flp-In(TM)-293) and MDR cancer cells (KB-vin and NCI-H460/MX20). beta Carotene 19-32 ATP binding cassette subfamily B member 1 Homo sapiens 148-153 15309450-6 2004 In addition, carotenoid- or retinol-mediated gene expression of PXR-responsive genes like CYP3A4/CYP3A7, CYP3A5, MDR-1 and MRP-2 has been determined in HepG2 cells by RT-PCR with up-regulative properties of beta-carotene or retinol being comparable to or even higher than that of rifampicin. beta Carotene 207-220 ATP binding cassette subfamily B member 1 Homo sapiens 113-118