PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28465253-3 2017 MATERIALS AND METHODS: Anti-inflammatory activity of CMEP-NQ was investigated in LPS-treated RAW264.7 cells by measuring the levels of NO, PGE2, and cytokines (IL1beta, IL-6, TNF-alpha) in the culture supernatants and the TLR4-mediated intracellular events including association of MyD88 with IRAK1, activation of IRAK1, TAK1, MAPKs, NF-kappaB/AP-1, and IRF3, and generation of ROS. 2-carbomethoxy-2,3-epoxy-3-prenyl-1,4-naphthoquinone 53-60 interleukin 1 beta Mus musculus 160-167