PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12808134-6 2003 Combined depletions of Akt1 plus Akt2 in these cells even more markedly attenuated insulin action on glucose transporter 4 movements, hexose transport activity, and GSK-3 phosphorylation. Hexoses 134-140 thymoma viral proto-oncogene 2 Mus musculus 33-37 14522993-4 2003 Here we show that Akt2/PKBbeta-/- adipocytes derived from immortalized mouse embryo fibroblasts display significantly reduced insulin-stimulated hexose uptake, clearly establishing that the partial defect in glucose disposal in these mice derives from lack of a cell autonomous function of Akt2/PKBbeta. Hexoses 145-151 thymoma viral proto-oncogene 2 Mus musculus 18-22 14522993-4 2003 Here we show that Akt2/PKBbeta-/- adipocytes derived from immortalized mouse embryo fibroblasts display significantly reduced insulin-stimulated hexose uptake, clearly establishing that the partial defect in glucose disposal in these mice derives from lack of a cell autonomous function of Akt2/PKBbeta. Hexoses 145-151 thymoma viral proto-oncogene 2 Mus musculus 23-30 14522993-5 2003 Moreover, in adipocytes differentiated from primary fibroblasts or immortalized mouse embryo fibroblasts, and brown preadipocytes the absence of Akt2/PKBbeta resulted in reduction of insulin-induced hexose uptake and glucose transporter 4 (GLUT4) translocation, whereas Akt1/PKBalpha was dispensable for this effect. Hexoses 199-205 thymoma viral proto-oncogene 2 Mus musculus 145-149 14522993-5 2003 Moreover, in adipocytes differentiated from primary fibroblasts or immortalized mouse embryo fibroblasts, and brown preadipocytes the absence of Akt2/PKBbeta resulted in reduction of insulin-induced hexose uptake and glucose transporter 4 (GLUT4) translocation, whereas Akt1/PKBalpha was dispensable for this effect. Hexoses 199-205 thymoma viral proto-oncogene 2 Mus musculus 150-157 14522993-6 2003 Most importantly, hexose uptake and GLUT4 translocation were completely restored after re-expression of Akt2/PKBbeta in Akt2/PKBbeta-/- adipocytes, but overexpression of Akt1/PKBalpha at comparable levels was ineffective at rescuing insulin action to normal. Hexoses 18-24 thymoma viral proto-oncogene 2 Mus musculus 104-108 14522993-6 2003 Most importantly, hexose uptake and GLUT4 translocation were completely restored after re-expression of Akt2/PKBbeta in Akt2/PKBbeta-/- adipocytes, but overexpression of Akt1/PKBalpha at comparable levels was ineffective at rescuing insulin action to normal. Hexoses 18-24 thymoma viral proto-oncogene 2 Mus musculus 109-116 14522993-6 2003 Most importantly, hexose uptake and GLUT4 translocation were completely restored after re-expression of Akt2/PKBbeta in Akt2/PKBbeta-/- adipocytes, but overexpression of Akt1/PKBalpha at comparable levels was ineffective at rescuing insulin action to normal. Hexoses 18-24 thymoma viral proto-oncogene 2 Mus musculus 120-124 14522993-6 2003 Most importantly, hexose uptake and GLUT4 translocation were completely restored after re-expression of Akt2/PKBbeta in Akt2/PKBbeta-/- adipocytes, but overexpression of Akt1/PKBalpha at comparable levels was ineffective at rescuing insulin action to normal. Hexoses 18-24 thymoma viral proto-oncogene 2 Mus musculus 125-132