PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2649887-5 1989 Microinjection of a monoclonal antibody directed against the tyrosine kinase domain of the human insulin receptor blocks activation of hexose uptake by insulin-like growth factor I and insulin but has no effect on basal uptake. Hexoses 135-141 insulin receptor Homo sapiens 97-113 6357090-6 1983 These effects appeared to be mediated via inhibitory actions on the hexose transport system with the preservation of a functional insulin-receptor interaction resulting in insulin stimulation of deoxy-D-glucose transport at physiological insulin concentrations, 250 microU/ml (10 ng/ml). Hexoses 68-74 insulin receptor Homo sapiens 130-146 6389533-0 1984 Effects of insulin receptor down-regulation on hexose transport in human erythrocytes. Hexoses 47-53 insulin receptor Homo sapiens 11-27 9354853-1 1997 Post-receptor signalling molecules that convey the signal from the activated insulin receptor to the actual process of Glut4 translocation and hexose uptake are poorly understood. Hexoses 143-149 insulin receptor Homo sapiens 77-93 1716452-7 1991 We conclude from these studies that (a) insulin inhibition of glycerol release can not be mediated directly by intracellular cAMP modulation, (b) as in the case of hexose transport activation, the signalling mechanism by the occupied insulin receptor appears to be relatively independent of the membrane lipid environment. Hexoses 164-170 insulin receptor Homo sapiens 234-250 1688999-6 1990 In the presence of the coexpressed human insulin receptor, insulin induced a two- to threefold increase in hexose transport. Hexoses 107-113 insulin receptor Homo sapiens 41-57 1688999-9 1990 We conclude that the expressed human insulin receptor is able to couple efficiently with preexisting postreceptor regulatory pathways in oocytes and that the regulation of hexose transport in these cells can be mediated through the combined actions of the expressed human insulin receptor and the endogenous oocyte insulin-like growth factor I receptor. Hexoses 172-178 insulin receptor Homo sapiens 37-53