PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15735728-5 2005 In both IL-3- treated cells and those expressing Bcr-Abl, high rates of hexose uptake were associated with the retention at the cell surface of approximately 80% of the total cellular content of the GLUT1 glucose transporter. Hexoses 72-78 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 49-56 15735728-6 2005 In contrast, treatment of Bcr-Abl-expressing cells for 6 h with the Bcr-Abl kinase inhibitor Glivec (10 muM), in the absence of IL-3, led to internalization of approximately 90% of the cell-surface transporters and drastically decreased (4.4+/-0.9 (mean+/-s.e.m., 4)-fold) the V(max) for hexose uptake, without significant effect on the K(m) for this process or on the total cellular transporter content. Hexoses 288-294 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 26-33 15735728-6 2005 In contrast, treatment of Bcr-Abl-expressing cells for 6 h with the Bcr-Abl kinase inhibitor Glivec (10 muM), in the absence of IL-3, led to internalization of approximately 90% of the cell-surface transporters and drastically decreased (4.4+/-0.9 (mean+/-s.e.m., 4)-fold) the V(max) for hexose uptake, without significant effect on the K(m) for this process or on the total cellular transporter content. Hexoses 288-294 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 68-75