PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8833992-0 1996 Interleukin 1 beta, tumor necrosis factor alpha, and interleukin 8 in bronchoalveolar lavage fluid of patients with diffuse panbronchiolitis: a potential mechanism of macrolide therapy. Macrolides 167-176 C-X-C motif chemokine ligand 8 Homo sapiens 53-66 14561211-13 2002 It has been shown that macrolides inhibit the production of IL-8 and IL-1beta and the expression of ICAM-1, suggesting that macrolides block the aforementioned dual positive feedback system of neutrophil recruitment and thereby exert their clinical efficacy in the treatment of chronic sinusitis. Macrolides 23-33 C-X-C motif chemokine ligand 8 Homo sapiens 60-64 7594798-5 1995 After treatment with macrolide antibiotics, significant reductions in the concentrations of defensins, IL-8 and neutrophil numbers in BALF of DPB patients were observed. Macrolides 21-30 C-X-C motif chemokine ligand 8 Homo sapiens 103-107 14561211-13 2002 It has been shown that macrolides inhibit the production of IL-8 and IL-1beta and the expression of ICAM-1, suggesting that macrolides block the aforementioned dual positive feedback system of neutrophil recruitment and thereby exert their clinical efficacy in the treatment of chronic sinusitis. Macrolides 124-134 C-X-C motif chemokine ligand 8 Homo sapiens 60-64 31283028-12 2019 The macrolides may reduce the IL-8 levels in the airway and plasma, but failed to demonstrate an antiviral effect in children with bronchiolitis. Macrolides 4-14 C-X-C motif chemokine ligand 8 Homo sapiens 30-34 18212111-2 2008 Those macrolides may attenuate the protease-activated receptor 2-interleukin-8 axis and thereby modulate proinflammatory responses in the skin. Macrolides 6-16 C-X-C motif chemokine ligand 8 Homo sapiens 65-78 26553025-10 2016 However, a trend toward decreased IL-6, IL-8, and IFN-gamma levels, and favorable clinical outcomes were present in the macrolide group. Macrolides 120-129 C-X-C motif chemokine ligand 8 Homo sapiens 40-44 26804595-14 2016 IL-8 antagonist and other anti-inflammation drugs like macrolides antibiotics, glucocorticoid and atorvastatin might be optional to resist the liquid cavity expanding as actually occurs obvious bleeding soon. Macrolides 55-65 C-X-C motif chemokine ligand 8 Homo sapiens 0-4 22925316-4 2012 The mechanism(s) of action of macrolides in the treatment of these diseases remains unexplained, but may be due to their antibacterial and/or anti-inflammatory actions, which include reductions in interleukin-8 production, neutrophil migration and/or function. Macrolides 30-40 C-X-C motif chemokine ligand 8 Homo sapiens 197-210 25849726-6 2015 RESULTS: Non-responders patients treated with macrolide containing regimens showed significantly lower levels of IL-6 and TNF-alpha in bronchoalveolar lavage fluid and lower IL-8 and IL-10 in blood than those patients treated with non-macrolide regimens. Macrolides 46-55 C-X-C motif chemokine ligand 8 Homo sapiens 174-178 22719178-6 2012 Much data showed that macrolides reduced viral titers of RV ICAM-1, which is the receptor for RV, and RV infection-induced cytokines including IL-1beta, IL-6, IL-8, and TNF-alpha. Macrolides 22-32 C-X-C motif chemokine ligand 8 Homo sapiens 159-163 19555716-11 2009 Macrolides have shown great promise in their ability to reduce airway inflammation, and can reduce airway neutrophils, levels of CXCL8 and neutrophil proteases in the airways. Macrolides 0-10 C-X-C motif chemokine ligand 8 Homo sapiens 129-134 15586558-6 2004 Macrolides inhibit the production of many proinflammatory cytokines, such as interleukin (IL)-1, IL-6, IL-8, and tumor necrosis factor-alpha, perhaps by suppressing the transcription factor nuclear factor-kappaB or activator protein-1. Macrolides 0-10 C-X-C motif chemokine ligand 8 Homo sapiens 103-140 18085018-3 2007 The most prominent effect of macrolides noted in vitro is the inhibition of pro-inflammatory cytokines such as interleukin-8. Macrolides 29-39 C-X-C motif chemokine ligand 8 Homo sapiens 111-124 17061983-0 2007 Macrolides inhibit IL17-induced IL8 and 8-isoprostane release from human airway smooth muscle cells. Macrolides 0-10 C-X-C motif chemokine ligand 8 Homo sapiens 32-35 17061983-11 2007 We conclude that macrolides (but not steroids/immunosuppressive agents) inhibit IL17-induced IL8 production in human primary airway smooth muscle cells via a reduction in MAPK activation and 8-isoprostane production. Macrolides 17-27 C-X-C motif chemokine ligand 8 Homo sapiens 93-96 17075545-2 2006 In vitro studies have demonstrated the anti-inflammatory effects of macrolides: decreased productions of IL-6, IL-8, TNF alpha, chemotactism of polymorphonuclear neutrophils. Macrolides 68-78 C-X-C motif chemokine ligand 8 Homo sapiens 111-115 16467702-7 2006 RESULTS: There were statistically significant improvements in SNOT-20 score, nasal endoscopy, saccharine transit time, and IL-8 levels in lavage fluid (P<.05) in the macrolide group. Macrolides 169-178 C-X-C motif chemokine ligand 8 Homo sapiens 123-127 17397353-2 2007 It is now clear that macrolide antibiotics have anti-inflammatory effects, such as inhibition of IL-6, IL-8 and tumour necrosis factor-alpha, perhaps by suppressing the transcription factor nuclear factor-kappaB or activator protein-1, and reduction of neutrophil activity. Macrolides 21-30 C-X-C motif chemokine ligand 8 Homo sapiens 103-140 15586558-7 2004 Inhibition of cytokine production has been seen in vitro and also in bronchoalveolar lavage fluid, which contains less IL-8 and fewer neutrophils after treatment with macrolides. Macrolides 167-177 C-X-C motif chemokine ligand 8 Homo sapiens 119-123 10887619-0 2000 Macrolide treatment decreased the size of nasal polyps and IL-8 levels in nasal lavage. Macrolides 0-9 C-X-C motif chemokine ligand 8 Homo sapiens 59-63 12088610-5 2002 Additionally, P. acnes-induced IL-8 secretion was inhibited by roxithromycin, a macrolide antibiotic, and its inhibitory effect seemed to be partially associated with the inhibition of P. acnes-induced NF-kappaB activation. Macrolides 80-89 C-X-C motif chemokine ligand 8 Homo sapiens 31-35 11270500-8 2001 Several studies have shown macrolides to inhibit interleukin gene expression for IL-6 and IL-8 and also to inhibit the expression of intercellular adhesion molecule essential for the recruitment of inflammatory cells. Macrolides 27-37 C-X-C motif chemokine ligand 8 Homo sapiens 90-94 10887619-3 2000 Lancet 351:420, 1998), and that macrolides can directly reduce the production of IL-8 by nasal epithelial cells (Suzuki H, Shimomura A, Ikeda K, et al. Macrolides 32-42 C-X-C motif chemokine ligand 8 Homo sapiens 81-85 10887619-7 2000 The IL-8 levels in nasal lavage from patients with nasal polyps were reduced during macrolide treatment. Macrolides 84-93 C-X-C motif chemokine ligand 8 Homo sapiens 4-8 10887619-9 2000 In the group whose polyps were reduced in size, the IL-8 levels dramatically decreased from 231.2 pg/mL to 44.0 pg/mL (p < 0.05), and were significantly higher before macrolide treatment than those in the group whose polyps showed no change (p < 0.005). Macrolides 170-179 C-X-C motif chemokine ligand 8 Homo sapiens 52-56 10887619-10 2000 This reduction in IL-8 may be an important aspect of the effect of macrolide treatment on nasal polyps in chronic rhinosinusitis. Macrolides 67-76 C-X-C motif chemokine ligand 8 Homo sapiens 18-22 10615065-12 2000 These data suggest that macrolides such as CAM repress IL-8 gene transcription mainly via the AP-1 binding site in human bronchial epithelial cells. Macrolides 24-34 C-X-C motif chemokine ligand 8 Homo sapiens 55-59 10867834-0 2000 Effects of macrolides on interleukin-8 secretion from human nasal epithelial cells. Macrolides 11-21 C-X-C motif chemokine ligand 8 Homo sapiens 25-38 11866799-4 1996 Macrolide therapy caused a significant reduction in the percentage of neutrophils, NCA and mean IL-1beta, IL-8 and LTB4 concentration in BAL fluid of the patients. Macrolides 0-9 C-X-C motif chemokine ligand 8 Homo sapiens 106-110 10867834-9 2000 These results suggest that macrolide treatment inhibits neutrophil infiltration and IL-8 secretion in nasal epithelium in vivo and that these clinical effects depend on a mechanism other than the direct action of macrolide on nasal epithelial cells. Macrolides 27-36 C-X-C motif chemokine ligand 8 Homo sapiens 84-88 9543278-9 1998 Treatment of DPB with macrolides for 6 months significantly reduced neutrophil count and concentrations of defensins and IL-8 in BALF. Macrolides 22-32 C-X-C motif chemokine ligand 8 Homo sapiens 121-125 9404762-10 1997 Treatment of DPB patients with macrolides significantly reduced the serum levels of these soluble adhesion molecules and BALF concentrations of IL-1 beta and IL-8. Macrolides 31-41 C-X-C motif chemokine ligand 8 Homo sapiens 158-162 9396683-0 1997 Inhibitory effect of macrolides on interleukin-8 secretion from cultured human nasal epithelial cells. Macrolides 21-31 C-X-C motif chemokine ligand 8 Homo sapiens 35-48 9396683-2 1997 The authors studied the effect of macrolides on interleukin (IL)-8 secretion from cultured human nasal epithelial cells. Macrolides 34-44 C-X-C motif chemokine ligand 8 Homo sapiens 48-66 9396683-7 1997 These results indicate that macrolide antibiotics may act as an immunomodulator to reduce IL-8 in inflammatory sites and, at least partially, account for the clinically discrepant effects between 14- and 16-membered ring macrolides in long-term low-dose therapy for chronic sinusitis. Macrolides 28-37 C-X-C motif chemokine ligand 8 Homo sapiens 90-94 9230759-7 1997 Among five patients who underwent bronchoscopy before and after macrolide treatment, four showed decreased levels of IL-8 expression in airway epithelium as assessed by reverse transcription and polymerase chain reaction. Macrolides 64-73 C-X-C motif chemokine ligand 8 Homo sapiens 117-121 9261930-0 1997 Effects of long-term low-dose macrolide administration on neutrophil recruitment and IL-8 in the nasal discharge of chronic sinusitis patients. Macrolides 30-39 C-X-C motif chemokine ligand 8 Homo sapiens 85-89 9597446-0 1997 [Effects of a steroid and macrolide antibiotic on IL-8 production by neutrophils]. Macrolides 26-35 C-X-C motif chemokine ligand 8 Homo sapiens 50-54 8831194-9 1996 We gave some evidences of macrolides effectiveness which these drugs inhibited IL-8 production. Macrolides 26-36 C-X-C motif chemokine ligand 8 Homo sapiens 79-83 11866799-6 1996 We also evaluated the in vitro inhibitory effects of macrolides on IL---8 production by vitamin D3-induced human monocytic cell line THP-1 cells when stimulated with lipopolysaccharide and serum. Macrolides 53-63 C-X-C motif chemokine ligand 8 Homo sapiens 67-73