PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15840574-2	2005	One of the key enzymes in this pathway is glyoxylate reductase/hydroxypyruvate reductase (GRHPR) whose dysfunction in human causes primary hyperoxaluria type 2, a disease resulting in oxalate accumulation and formation of kidney stones.	Oxalates	184-191	glyoxylate and hydroxypyruvate reductase	Homo sapiens	42-62	
32003182-2	2019	The mutations in the AGXT, GRHPR, HOGA1 genes are attributable for different types of primary hyperoxaluria leading to the dysfunction of specific enzymes involved in the oxalate metabolism.	Oxalates	171-178	glyoxylate and hydroxypyruvate reductase	Homo sapiens	27-32	
22771891-11	2012	Thus, one hypothetical component of the molecular basis for the excessive oxalate production in PH3 appears to be the inhibition of GR by HOG, resulting in a phenotype similar to PH2.	Oxalates	74-81	glyoxylate and hydroxypyruvate reductase	Homo sapiens	132-134	
21304260-3	2011	The activity of serine : pyruvate/alanine : glyoxylate aminotransferase (SPT/AGT) or glyoxylate reductase/hydroxypyruvate reductase (GRHPR), the key enzyme of primary hyperoxlauria type 1 and 2, respectively, and their subcellular distribution highly affects the oxalate production.	Oxalates	263-270	glyoxylate and hydroxypyruvate reductase	Homo sapiens	85-105	
21304260-3	2011	The activity of serine : pyruvate/alanine : glyoxylate aminotransferase (SPT/AGT) or glyoxylate reductase/hydroxypyruvate reductase (GRHPR), the key enzyme of primary hyperoxlauria type 1 and 2, respectively, and their subcellular distribution highly affects the oxalate production.	Oxalates	263-270	glyoxylate and hydroxypyruvate reductase	Homo sapiens	106-131	
21304260-3	2011	The activity of serine : pyruvate/alanine : glyoxylate aminotransferase (SPT/AGT) or glyoxylate reductase/hydroxypyruvate reductase (GRHPR), the key enzyme of primary hyperoxlauria type 1 and 2, respectively, and their subcellular distribution highly affects the oxalate production.	Oxalates	263-270	glyoxylate and hydroxypyruvate reductase	Homo sapiens	133-138	
19296982-2	2009	Primary hyperoxaluria type 2 is a rare autosomal recessive disease caused by mutations in the GRHPR gene, leading to an accumulation of oxalate and L-glycerate with recurrent kidney stone formation and nephrocalcinosis, and the later development of renal failure and systemic oxalate depositions.	Oxalates	136-143	glyoxylate and hydroxypyruvate reductase	Homo sapiens	94-99	
19296982-2	2009	Primary hyperoxaluria type 2 is a rare autosomal recessive disease caused by mutations in the GRHPR gene, leading to an accumulation of oxalate and L-glycerate with recurrent kidney stone formation and nephrocalcinosis, and the later development of renal failure and systemic oxalate depositions.	Oxalates	276-283	glyoxylate and hydroxypyruvate reductase	Homo sapiens	94-99	
18982322-2	2008	Primary hyperoxaluria type 2 (PH2) is a rare inherited disease caused by overproduction of endogenous oxalate due to mutations in the glyoxylate/hydroxypyruvate reductase (GRHPR) gene.	Oxalates	102-109	glyoxylate and hydroxypyruvate reductase	Homo sapiens	145-170	
18982322-2	2008	Primary hyperoxaluria type 2 (PH2) is a rare inherited disease caused by overproduction of endogenous oxalate due to mutations in the glyoxylate/hydroxypyruvate reductase (GRHPR) gene.	Oxalates	102-109	glyoxylate and hydroxypyruvate reductase	Homo sapiens	172-177	
16198644-10	2005	The potential roles of LDH isoforms and GRHPR in oxalate synthesis are discussed.	Oxalates	49-56	glyoxylate and hydroxypyruvate reductase	Homo sapiens	40-45	
30907303-3	2019	Alanine glyoxylate aminotransferase-1 and glyoxylate reductase, the enzymes involving glyoxylate (precursor for oxalate) metabolism, have been related to primary hyperoxalurias.	Oxalates	112-119	glyoxylate and hydroxypyruvate reductase	Homo sapiens	0-62	
16309382-6	2006	These results are compatible with the findings in PH1 and PH2, in which AGT and GR/HPR deficiencies lead to increased oxalate synthesis, due to the failure to detoxify its immediate precursor glyoxylate.	Oxalates	118-125	glyoxylate and hydroxypyruvate reductase	Homo sapiens	58-61	
15840574-2	2005	One of the key enzymes in this pathway is glyoxylate reductase/hydroxypyruvate reductase (GRHPR) whose dysfunction in human causes primary hyperoxaluria type 2, a disease resulting in oxalate accumulation and formation of kidney stones.	Oxalates	184-191	glyoxylate and hydroxypyruvate reductase	Homo sapiens	63-88	
15840574-2	2005	One of the key enzymes in this pathway is glyoxylate reductase/hydroxypyruvate reductase (GRHPR) whose dysfunction in human causes primary hyperoxaluria type 2, a disease resulting in oxalate accumulation and formation of kidney stones.	Oxalates	184-191	glyoxylate and hydroxypyruvate reductase	Homo sapiens	90-95	
12185464-1	2002	The primary hyperoxalurias (PH1 and PH2) are rare defects of oxalate overproduction.	Oxalates	61-68	glyoxylate and hydroxypyruvate reductase	Homo sapiens	36-39	
14635115-1	2003	Primary hyperoxaluria type 2, an inherited autosomal recessive disorder of endogenous oxalate overproduction, is caused by mutations in the GRHPR gene encoding the glyoxylate/hydroxypyruvate reductase enzyme.	Oxalates	86-93	glyoxylate and hydroxypyruvate reductase	Homo sapiens	140-145	
12185464-2	2002	There are only 24 reported cases of PH2, which is characterized by raised urine oxalate and L-glycerate.	Oxalates	80-87	glyoxylate and hydroxypyruvate reductase	Homo sapiens	36-39	
8311084-2	1994	Deficiencies of D-glycerate dehydrogenase and glyoxylate reductase activity in patients with this disorder leads to increases in urinary oxalate and glycerate excretion.	Oxalates	137-144	glyoxylate and hydroxypyruvate reductase	Homo sapiens	46-66	
11156703-1	2000	Primary hyperoxaluria Type II (PH2) is a rare monogenic disease characterized by excessive urinary oxalate and L-glycerate excretion.	Oxalates	99-106	glyoxylate and hydroxypyruvate reductase	Homo sapiens	31-34