PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8383677-2	1993	In human monocytes, the inhibitors of these phosphatases, okadaic acid and calyculin A, were found to increase the mRNA accumulation and cytokine production of interleukin-1 beta and interleukin-1 alpha.	Okadaic Acid	58-70	interleukin 1 alpha	Homo sapiens	183-202	
9010681-4	1996	Inhibition by okadaic acid of serine/threonine specific phosphatases resulted in a marked increase in interleukin-1 stimulated MEK and MAP kinase activities.	Okadaic Acid	14-26	interleukin 1 alpha	Homo sapiens	102-115	
8383677-7	1993	The stimulation of interleukin-1 alpha production by okadaic acid was more modest than that of interleukin-1 beta.	Okadaic Acid	53-65	interleukin 1 alpha	Homo sapiens	19-38	
1377908-0	1992	Okadaic acid, an inhibitor of protein phosphatases 1 and 2A, inhibits induction of acute-phase proteins by interleukin-6 alone or in combination with interleukin-1 in human hepatoma cell lines.	Okadaic Acid	0-12	interleukin 1 alpha	Homo sapiens	150-163	
1377908-1	1992	Okadaic acid (OA), a specific inhibitor of protein phosphatases 1 and 2A, inhibited in a dose-dependent manner (5-20 nM) the induction of C-reactive protein (CRP), serum amyloid A (SAA) and fibrinogen by interleukin-6 (IL-6) plus interleukin-1 (IL-1), and of fibrinogen by IL-6 alone, in Hep 3B cells.	Okadaic Acid	14-16	interleukin 1 alpha	Homo sapiens	230-243	
1377908-1	1992	Okadaic acid (OA), a specific inhibitor of protein phosphatases 1 and 2A, inhibited in a dose-dependent manner (5-20 nM) the induction of C-reactive protein (CRP), serum amyloid A (SAA) and fibrinogen by interleukin-6 (IL-6) plus interleukin-1 (IL-1), and of fibrinogen by IL-6 alone, in Hep 3B cells.	Okadaic Acid	14-16	interleukin 1 alpha	Homo sapiens	245-249	
1377908-1	1992	Okadaic acid (OA), a specific inhibitor of protein phosphatases 1 and 2A, inhibited in a dose-dependent manner (5-20 nM) the induction of C-reactive protein (CRP), serum amyloid A (SAA) and fibrinogen by interleukin-6 (IL-6) plus interleukin-1 (IL-1), and of fibrinogen by IL-6 alone, in Hep 3B cells.	Okadaic Acid	0-12	interleukin 1 alpha	Homo sapiens	230-243	
1377908-1	1992	Okadaic acid (OA), a specific inhibitor of protein phosphatases 1 and 2A, inhibited in a dose-dependent manner (5-20 nM) the induction of C-reactive protein (CRP), serum amyloid A (SAA) and fibrinogen by interleukin-6 (IL-6) plus interleukin-1 (IL-1), and of fibrinogen by IL-6 alone, in Hep 3B cells.	Okadaic Acid	0-12	interleukin 1 alpha	Homo sapiens	245-249	
1370482-0	1992	Okadaic acid mimics multiple changes in early protein phosphorylation and gene expression induced by tumor necrosis factor or interleukin-1.	Okadaic Acid	0-12	interleukin 1 alpha	Homo sapiens	126-139	
1370482-1	1992	Okadaic acid, a phosphatase inhibitor from a marine organism, mimics tumor necrosis factor/interleukin-1 (TNF/IL-1) in inducing changes in early cellular protein phosphorylation.	Okadaic Acid	0-12	interleukin 1 alpha	Homo sapiens	91-104	
1370482-1	1992	Okadaic acid, a phosphatase inhibitor from a marine organism, mimics tumor necrosis factor/interleukin-1 (TNF/IL-1) in inducing changes in early cellular protein phosphorylation.	Okadaic Acid	0-12	interleukin 1 alpha	Homo sapiens	110-114	
2033250-8	1991	However, when cultures were treated with the protein phosphatase inhibitor okadaic acid alone, the level of pP29 increased after 1 h and the presence of okadaic acid during prolonged IL-1 treatment blocked the decline in pP29.	Okadaic Acid	75-87	interleukin 1 alpha	Homo sapiens	183-187	
2033250-8	1991	However, when cultures were treated with the protein phosphatase inhibitor okadaic acid alone, the level of pP29 increased after 1 h and the presence of okadaic acid during prolonged IL-1 treatment blocked the decline in pP29.	Okadaic Acid	153-165	interleukin 1 alpha	Homo sapiens	183-187