PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1370482-0 1992 Okadaic acid mimics multiple changes in early protein phosphorylation and gene expression induced by tumor necrosis factor or interleukin-1. Okadaic Acid 0-12 interleukin 1 alpha Homo sapiens 126-139 1377908-0 1992 Okadaic acid, an inhibitor of protein phosphatases 1 and 2A, inhibits induction of acute-phase proteins by interleukin-6 alone or in combination with interleukin-1 in human hepatoma cell lines. Okadaic Acid 0-12 interleukin 1 alpha Homo sapiens 150-163 1377908-1 1992 Okadaic acid (OA), a specific inhibitor of protein phosphatases 1 and 2A, inhibited in a dose-dependent manner (5-20 nM) the induction of C-reactive protein (CRP), serum amyloid A (SAA) and fibrinogen by interleukin-6 (IL-6) plus interleukin-1 (IL-1), and of fibrinogen by IL-6 alone, in Hep 3B cells. Okadaic Acid 0-12 interleukin 1 alpha Homo sapiens 230-243 1377908-1 1992 Okadaic acid (OA), a specific inhibitor of protein phosphatases 1 and 2A, inhibited in a dose-dependent manner (5-20 nM) the induction of C-reactive protein (CRP), serum amyloid A (SAA) and fibrinogen by interleukin-6 (IL-6) plus interleukin-1 (IL-1), and of fibrinogen by IL-6 alone, in Hep 3B cells. Okadaic Acid 0-12 interleukin 1 alpha Homo sapiens 245-249 9010681-4 1996 Inhibition by okadaic acid of serine/threonine specific phosphatases resulted in a marked increase in interleukin-1 stimulated MEK and MAP kinase activities. Okadaic Acid 14-26 interleukin 1 alpha Homo sapiens 102-115 8383677-2 1993 In human monocytes, the inhibitors of these phosphatases, okadaic acid and calyculin A, were found to increase the mRNA accumulation and cytokine production of interleukin-1 beta and interleukin-1 alpha. Okadaic Acid 58-70 interleukin 1 alpha Homo sapiens 183-202 8383677-7 1993 The stimulation of interleukin-1 alpha production by okadaic acid was more modest than that of interleukin-1 beta. Okadaic Acid 53-65 interleukin 1 alpha Homo sapiens 19-38 1377908-1 1992 Okadaic acid (OA), a specific inhibitor of protein phosphatases 1 and 2A, inhibited in a dose-dependent manner (5-20 nM) the induction of C-reactive protein (CRP), serum amyloid A (SAA) and fibrinogen by interleukin-6 (IL-6) plus interleukin-1 (IL-1), and of fibrinogen by IL-6 alone, in Hep 3B cells. Okadaic Acid 14-16 interleukin 1 alpha Homo sapiens 230-243 1377908-1 1992 Okadaic acid (OA), a specific inhibitor of protein phosphatases 1 and 2A, inhibited in a dose-dependent manner (5-20 nM) the induction of C-reactive protein (CRP), serum amyloid A (SAA) and fibrinogen by interleukin-6 (IL-6) plus interleukin-1 (IL-1), and of fibrinogen by IL-6 alone, in Hep 3B cells. Okadaic Acid 14-16 interleukin 1 alpha Homo sapiens 245-249 1370482-1 1992 Okadaic acid, a phosphatase inhibitor from a marine organism, mimics tumor necrosis factor/interleukin-1 (TNF/IL-1) in inducing changes in early cellular protein phosphorylation. Okadaic Acid 0-12 interleukin 1 alpha Homo sapiens 91-104 1370482-1 1992 Okadaic acid, a phosphatase inhibitor from a marine organism, mimics tumor necrosis factor/interleukin-1 (TNF/IL-1) in inducing changes in early cellular protein phosphorylation. Okadaic Acid 0-12 interleukin 1 alpha Homo sapiens 110-114 2033250-8 1991 However, when cultures were treated with the protein phosphatase inhibitor okadaic acid alone, the level of pP29 increased after 1 h and the presence of okadaic acid during prolonged IL-1 treatment blocked the decline in pP29. Okadaic Acid 75-87 interleukin 1 alpha Homo sapiens 183-187 2033250-8 1991 However, when cultures were treated with the protein phosphatase inhibitor okadaic acid alone, the level of pP29 increased after 1 h and the presence of okadaic acid during prolonged IL-1 treatment blocked the decline in pP29. Okadaic Acid 153-165 interleukin 1 alpha Homo sapiens 183-187