PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28369648-4	2017	P450 enzymes metabolize chlorpyrifos to chlorpyrifos-oxon, which is then metabolized primarily to 3, 5, 6-trichloropyridinol in addition to diethylphosphate and diethylthiophosphate.	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	40-57	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	0-4	
20709133-7	2010	CPO formation was best correlated with CYP2B6 related activity at low (20 muM) chlorpyrifos concentrations while CYP3A4 related activity was best correlated with CPO formation at high concentrations (100 muM) of chlorpyrifos.	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	0-3	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	39-45	
26075493-3	2015	CYP2B6 was previously determined to have the greatest catalytic efficiency for CPO formation in vitro.	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	79-82	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	0-6	
17079358-7	2007	With K(m) and V(max) values of 0.61 microM, 4827 pmol/min/nmol P450 and 0.81 microM, 12,544 pmol/min/nmol for formation of paraoxon and chlorpyrifos-oxon, respectively, CYP2B6 favored the desulfation reaction.	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	136-153	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	63-67	
17079358-7	2007	With K(m) and V(max) values of 0.61 microM, 4827 pmol/min/nmol P450 and 0.81 microM, 12,544 pmol/min/nmol for formation of paraoxon and chlorpyrifos-oxon, respectively, CYP2B6 favored the desulfation reaction.	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	136-153	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	169-175	
29463407-2	2018	Chlorpyrifos oxon (CPO) is a toxic metabolite of CPS that is produced by CYP2B6.	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	0-17	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	73-79	
18447001-6	2007	CYP2B6, the most efficient isoform for BALC production, was inhibited by CPO, while CYP3A4, the most efficient isoform for ET production, was activated by CPO.	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	73-76	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	0-6	
18447001-6	2007	CYP2B6, the most efficient isoform for BALC production, was inhibited by CPO, while CYP3A4, the most efficient isoform for ET production, was activated by CPO.	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	155-158	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	0-6	
18447001-7	2007	CPO inhibited CYP2B6 production of both BALC and ET from DEET, but activated CYP3A4 production of ET, while inhibiting CYP3A4 BALC production.	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	0-3	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	14-20	
35243363-6	2022	5) Age-related refinements for CPF/CPFO were primarily from ToxCast/Tox21 active hit-calls for nuclear receptors, CYP2B6 and AChE inhibition (CPFO only) associated with the metabolic pathway.	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	35-39	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	114-120	
29463407-2	2018	Chlorpyrifos oxon (CPO) is a toxic metabolite of CPS that is produced by CYP2B6.	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	19-22	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	73-79	
29463407-6	2018	The conversion of CPS to CPO by the CYP2B6 variants was analyzed with high-performance liquid chromatography.	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	25-28	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	36-42	
29463407-8	2018	The CYP2B6 variants produced CPO with the following kinetic parameters: Km for CYP2B6.5 and CYP2B6.8 were 20.44+-6.43 and 44.69+-9.97muM, respectively; and Vmax were 1.10+-0.10 and 1.77+-0.26mol/min/mol P450, respectively.	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	29-32	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	4-10	
29463407-8	2018	The CYP2B6 variants produced CPO with the following kinetic parameters: Km for CYP2B6.5 and CYP2B6.8 were 20.44+-6.43 and 44.69+-9.97muM, respectively; and Vmax were 1.10+-0.10 and 1.77+-0.26mol/min/mol P450, respectively.	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	29-32	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	79-85	
29463407-8	2018	The CYP2B6 variants produced CPO with the following kinetic parameters: Km for CYP2B6.5 and CYP2B6.8 were 20.44+-6.43 and 44.69+-9.97muM, respectively; and Vmax were 1.10+-0.10 and 1.77+-0.26mol/min/mol P450, respectively.	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	29-32	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	79-85