PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33559204-5 2021 The results showed that SiO2 stimulated the production of reactive oxygen species and malondialdehyde in the supernatant of THP-1-derived macrophages and increased the secretion of TGF-beta1, TNF-alpha, and IL-8. Silicon Dioxide 24-28 C-X-C motif chemokine ligand 8 Homo sapiens 207-211 6946109-1 1981 Fluoride uptake into decalcified human enamel was determined from in situ brushing with a 0.40% SnF2-calcium pyrophosphate abrasive dentifrice, a 0.243% NaF-silica abrasive dentifrice, and a non-fluoride-silica abrasive placebo dentifrice. Silicon Dioxide 157-163 C-X-C motif chemokine ligand 8 Homo sapiens 153-156 33629550-8 2020 Conclusion: 100 mug/ml Nano-SiO2 combined with 31C cold exposure can synergistically reduce the activity of A549 cells and increase the expression level of inflammatory factors IL-6 and IL-8 . Silicon Dioxide 28-32 C-X-C motif chemokine ligand 8 Homo sapiens 186-190 32088457-8 2020 SiO2 and Al2O3 exerted a thermally positive effect on NaF turning into CaF2. Silicon Dioxide 0-4 C-X-C motif chemokine ligand 8 Homo sapiens 54-57 32885098-7 2020 Both 15% Ag-SiO2 and CuO exposure produced significantly higher levels of IL-8 in the co-culture compared with A549 cells alone. Silicon Dioxide 12-16 C-X-C motif chemokine ligand 8 Homo sapiens 74-78 32319286-9 2020 Exposure of differentiated Caco-2 cells to positively or negatively surface-charged SiO2 NPs also upregulated interleukin-8 expression. Silicon Dioxide 84-88 C-X-C motif chemokine ligand 8 Homo sapiens 110-123 27090657-3 2016 Monomer 2,7-(2-hydroxy-3-methacryloyloxypropoxy)naphthalene (2,7-NAF.DM) with luminophoric properties was immobilized on silica and carbon nanotubes in two ways: mechanical mixing with previously obtained polymer and by in situ oligomerization with chemisorption after carrier"s modification with vinyl groups. Silicon Dioxide 121-127 C-X-C motif chemokine ligand 8 Homo sapiens 65-68 31520180-7 2019 The secretions of IL-8, TNF-alpha, IL-6 and IL-17A were also significantly increased by silica particles (P < 0.05). Silicon Dioxide 88-94 C-X-C motif chemokine ligand 8 Homo sapiens 18-22 31520180-9 2019 The secreted levels of IL-8, TNF-alpha, IL-6 and IL-17A induced by silica particles were also significantly lower from CTGF siRNA-transfected cells than that from normal 16HBE cells (P < 0.05). Silicon Dioxide 67-73 C-X-C motif chemokine ligand 8 Homo sapiens 23-27 31407890-7 2019 Concentrations of interleukin (IL)-1beta, IL-6, IL-8, and tumor necrosis factor-alpha in macrophage supernatant increased following 100 mug/mL silica exposure for 24 h. Treatment of AMs with 500 muM FAC decreased both oxidant generation and cytokine release associated with silica exposure, supporting a dependence of these effects on sequestration of cell metal by the particle surface. Silicon Dioxide 143-149 C-X-C motif chemokine ligand 8 Homo sapiens 48-52 30861304-2 2019 Previously, we have shown that silica nanoparticles sized 50 nm (Si50) induce release of CXCL8 and IL-6 from BEAS-2B cells, via mechanisms involving NFkappaB, p38 MAP kinase and TGF-alpha-activated EGF receptor. Silicon Dioxide 31-37 C-X-C motif chemokine ligand 8 Homo sapiens 89-94 29334172-1 2018 We have previously reported that silica nanoparticles (SiNPs) of nominal size 50 nm (Si50) induce the pro-inflammatory cytokines CXCL8 and IL-6 in BEAS-2B cells, via mechanisms involving MAPK p38, TACE-mediated TGF-alpha release and the NF-kappaB pathway. Silicon Dioxide 33-39 C-X-C motif chemokine ligand 8 Homo sapiens 129-134 24844442-1 2014 Amorphous silica nanoparticles (SiNPs) have previously been shown to induce marked cytokine (interleukin-6; IL-6 and interleukin-8; CXCL8/IL-8) responses independently of particle uptake in human bronchial epithelial BEAS-2B cells. Silicon Dioxide 10-16 C-X-C motif chemokine ligand 8 Homo sapiens 117-130 27076279-1 2016 A sensitive and convenient electrochemical method was developed for the determination of rhodamine B by a silica-pillared zirconium phosphate/nafion composite (SPZP/NAF) modified glassy carbon electrode. Silicon Dioxide 106-112 C-X-C motif chemokine ligand 8 Homo sapiens 165-168 27557865-3 2016 This study aimed to compare dental stain control of twice-daily brushing with a sodium fluoride (NaF) dentifrice containing 67 % sodium bicarbonate (NaHCO3) or a commercially available NaF silica dentifrice without NaHCO3, while using a mouthwash containing 0.2 % CHX. Silicon Dioxide 189-195 C-X-C motif chemokine ligand 8 Homo sapiens 185-188 26505033-2 2015 Hollow silica microsphere-containing acrylate resin-based dental restoration materials were prepared by using hollow silica microspheres as NaF reservoirs. Silicon Dioxide 7-13 C-X-C motif chemokine ligand 8 Homo sapiens 140-143 24844442-1 2014 Amorphous silica nanoparticles (SiNPs) have previously been shown to induce marked cytokine (interleukin-6; IL-6 and interleukin-8; CXCL8/IL-8) responses independently of particle uptake in human bronchial epithelial BEAS-2B cells. Silicon Dioxide 10-16 C-X-C motif chemokine ligand 8 Homo sapiens 132-137 24844442-1 2014 Amorphous silica nanoparticles (SiNPs) have previously been shown to induce marked cytokine (interleukin-6; IL-6 and interleukin-8; CXCL8/IL-8) responses independently of particle uptake in human bronchial epithelial BEAS-2B cells. Silicon Dioxide 10-16 C-X-C motif chemokine ligand 8 Homo sapiens 138-142 16963169-11 2006 However, the silica-induced up-regulation of IL-8 release through the SFK-ERK1/2 pathway does not appear to be initiated through activation of the EGFR, although basal EGFR activity may affect the magnitude of the responses. Silicon Dioxide 13-19 C-X-C motif chemokine ligand 8 Homo sapiens 45-49 23885223-6 2013 Therefore, these results provide immunological information about amorphous silica nanoparticles and suggest that amorphous silica nanoparticles can evoke innate immune reactions in human monocytes through production of IL-1beta and IL-8. Silicon Dioxide 123-129 C-X-C motif chemokine ligand 8 Homo sapiens 232-236 23878839-14 2013 Overall, the degree of remineralisation was as follows: NaF-silica-pyrophosphate dentifrices (1000 ppm F) averaged 41%; NaF/MFP-silica (1500/1000 ppm F) 38%; MFP/NaF-dicalcium phosphate (1000/450 ppm F) 30%; MFP dentifrices (1000 ppm F) ranged from 15 to 23%. Silicon Dioxide 60-66 C-X-C motif chemokine ligand 8 Homo sapiens 56-59 21750917-1 2012 The aim of this study was to evaluate the remineralization potential of three silica-containing NaF dentifrice systems in an intraoral model. Silicon Dioxide 78-84 C-X-C motif chemokine ligand 8 Homo sapiens 96-99 21623439-2 2011 Here, we report a one-pot synthesis of doxorubicin-doped silica nanoparticles (Dox/SiNPs) by using sodium fluoride (NaF) catalyzed hydrolysis of tetraethyl orthosilicate in a water-in-oil microemulsion. Silicon Dioxide 57-63 C-X-C motif chemokine ligand 8 Homo sapiens 116-119 22403987-14 2011 CONCLUSION: The test toothpaste containing 8% strontium acetate and 1040 ppm fluoride as NaF in a silica base, when used for a single topical application and twice-daily brushing for seven days, does not provide statistically significant relief of dentin hypersensitivity compared to a negative control toothpaste containing 1100 ppm fluoride as NaF in a silica base. Silicon Dioxide 98-104 C-X-C motif chemokine ligand 8 Homo sapiens 89-92 19014534-0 2008 IL-1beta differently involved in IL-8 and FGF-2 release in crystalline silica-treated lung cell co-cultures. Silicon Dioxide 71-77 C-X-C motif chemokine ligand 8 Homo sapiens 33-37 19014534-2 2008 The aim of the present study was to investigate the effect of crystalline silica on the release of the fibrosis- and angiogenesis-related mediator FGF-2 and the pro-inflammatory mediator IL-8, and how IL-1beta and TNF-alpha were involved in this release from various mono- and co-cultures of monocytes, pneumocytes and endothelial cells. Silicon Dioxide 74-80 C-X-C motif chemokine ligand 8 Homo sapiens 187-191 19014534-3 2008 RESULTS: Silica exposure induced an increase of IL-8 release from monocytes and from pneumocytes alone, and the FGF-2 level in the medium increased upon silica exposure of pneumocytes. Silicon Dioxide 9-15 C-X-C motif chemokine ligand 8 Homo sapiens 48-52 19014534-10 2008 CONCLUSION: IL-1beta seems to be differently involved in the silica-induced release of IL-8 and FGF-2 in different lung cell cultures. Silicon Dioxide 61-67 C-X-C motif chemokine ligand 8 Homo sapiens 87-91 19014534-11 2008 Whereas the silica-induced IL-8 release is regulated via an IL-1-receptor-mediated mechanism, IL-1beta is suggested only indirectly to affect the silica-induced FGF-2 release by counteracting pneumocyte loss. Silicon Dioxide 12-18 C-X-C motif chemokine ligand 8 Homo sapiens 27-31 18715885-3 2008 The time courses for silica-induced release of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-8 both from co-cultures and monocyte mono-cultures showed an early peak at 5-10 h, almost no response at 20 h, and a strong increase at 43 h. At 43 h, co-cultures also showed strongly increased IL-6 levels. Silicon Dioxide 21-27 C-X-C motif chemokine ligand 8 Homo sapiens 110-114 18715885-4 2008 Steady-state levels of mRNA roughly exhibited the same pattern of early up-regulation and reduced levels at 20 h. Compared with monocyte mono-cultures, silica induced a strong release of IL-1beta, IL-6, and IL-8, but not of TNF-alpha, after 43 h in co-cultures, whereas at 5 and 10 h a significant difference was only observed for the silica-induced IL-8 response. Silicon Dioxide 152-158 C-X-C motif chemokine ligand 8 Homo sapiens 207-211 18715885-4 2008 Steady-state levels of mRNA roughly exhibited the same pattern of early up-regulation and reduced levels at 20 h. Compared with monocyte mono-cultures, silica induced a strong release of IL-1beta, IL-6, and IL-8, but not of TNF-alpha, after 43 h in co-cultures, whereas at 5 and 10 h a significant difference was only observed for the silica-induced IL-8 response. Silicon Dioxide 152-158 C-X-C motif chemokine ligand 8 Homo sapiens 350-354 23997175-8 2013 Silica exposure activated MAP kinases (ERK and p38) and altered the expression of transcription factors (nF-kappaB and NF-E2-related factor 2), proinflammatory cytokines (interleukin-8 and -6), and apoptotic proteins. Silicon Dioxide 0-6 C-X-C motif chemokine ligand 8 Homo sapiens 171-191 23397001-6 2012 However, all three different sizes of silica nanoparticles induced IL-8 production. Silicon Dioxide 38-44 C-X-C motif chemokine ligand 8 Homo sapiens 67-71 23397001-9 2012 Therefore, IL-8 production induced by silica nanoparticles may be dependent on other mechanisms rather than intracellular Ca(++) increase and ROS generation. Silicon Dioxide 38-44 C-X-C motif chemokine ligand 8 Homo sapiens 11-15 16963169-0 2006 Mechanisms of silica-induced IL-8 release from A549 cells: initial kinase-activation does not require EGFR activation or particle uptake. Silicon Dioxide 14-20 C-X-C motif chemokine ligand 8 Homo sapiens 29-33 16963169-8 2006 The EGFR inhibitor AG1478 attenuated both silica-induced IL-8 release and phosphorylation of SFKs and ERK1/2. Silicon Dioxide 42-48 C-X-C motif chemokine ligand 8 Homo sapiens 57-61 15349669-5 2004 Analysis of the thin section by SEM after exposure to dentifrices showed that NaF/SiO(2) produced significant remineralization whereas MFP/CaCO(3) system resulted in little remineralization. Silicon Dioxide 82-88 C-X-C motif chemokine ligand 8 Homo sapiens 78-81 16142980-8 2005 Besides, while the condensation of silica took place after addition of NaF, the N value increased only very little with time up to the point where a small amount of mesostructured material precipitated out. Silicon Dioxide 35-41 C-X-C motif chemokine ligand 8 Homo sapiens 71-74 15240896-3 2004 Our results show that silica particles induced a concentration- and time-dependent increase in interleukin (IL)-8 release from the human epithelial lung cell line A549. Silicon Dioxide 22-28 C-X-C motif chemokine ligand 8 Homo sapiens 95-113 15240896-5 2004 However, IL-8 induction was most efficiently inhibited by the Src family kinase (SFK) inhibitor, PP2, suggesting a crucial role of SFKs in regulating silica-induced IL-8 release from A549 cells. Silicon Dioxide 150-156 C-X-C motif chemokine ligand 8 Homo sapiens 9-13 15240896-5 2004 However, IL-8 induction was most efficiently inhibited by the Src family kinase (SFK) inhibitor, PP2, suggesting a crucial role of SFKs in regulating silica-induced IL-8 release from A549 cells. Silicon Dioxide 150-156 C-X-C motif chemokine ligand 8 Homo sapiens 165-169 15240896-9 2004 Our results suggest the presence of two separate signaling pathways which are important in the regulation of silica-induced IL-8 release from A549 cells; one involving SFK-dependent activation of ERK1/2, and the other activation of p38, at least partly independent of SFKs. Silicon Dioxide 109-115 C-X-C motif chemokine ligand 8 Homo sapiens 124-128 18968742-7 2002 Potential interference from dissolved silica and Fe(III) is eliminated by the addition of NaF to the sample. Silicon Dioxide 38-44 C-X-C motif chemokine ligand 8 Homo sapiens 90-93 12881895-8 2000 However, much more IL-8 was released into the tissue culture supernatant by SiO2 at the same levels of cytotoxicity than by Ni3S2. Silicon Dioxide 76-80 C-X-C motif chemokine ligand 8 Homo sapiens 19-23 10930308-0 2000 Nuclear factor-kappa b activation in silica-induced interleukin 8 production by human bronchial epithelial cells. Silicon Dioxide 37-43 C-X-C motif chemokine ligand 8 Homo sapiens 52-65 10930308-1 2000 Recent studies indicate that interleukin 8 (IL-8) plays an important role in interstitial lung diseases including silica-induced lung inflammation. Silicon Dioxide 114-120 C-X-C motif chemokine ligand 8 Homo sapiens 29-42 10930308-1 2000 Recent studies indicate that interleukin 8 (IL-8) plays an important role in interstitial lung diseases including silica-induced lung inflammation. Silicon Dioxide 114-120 C-X-C motif chemokine ligand 8 Homo sapiens 44-48 10930308-4 2000 The administration of silica induced IL-8 production in BET-1A dose-dependently and time-dependently. Silicon Dioxide 22-28 C-X-C motif chemokine ligand 8 Homo sapiens 37-41 10930308-5 2000 Northern blot analysis demonstrated that silica upregulated IL-8 expression in BET-1A. Silicon Dioxide 41-47 C-X-C motif chemokine ligand 8 Homo sapiens 60-64 9238872-3 1997 2.0% Gantrez co-polymer and 0.243% NaF in a silica abrasive base. Silicon Dioxide 44-50 C-X-C motif chemokine ligand 8 Homo sapiens 35-38 8951626-12 1996 The results demonstrated that a 3% KNO3/Silica/NaF mouthwash compared to a Silica/NaF control significantly reduced CDS when evaluated by tactile and thermal stimuli. Silicon Dioxide 40-46 C-X-C motif chemokine ligand 8 Homo sapiens 47-50 8951626-12 1996 The results demonstrated that a 3% KNO3/Silica/NaF mouthwash compared to a Silica/NaF control significantly reduced CDS when evaluated by tactile and thermal stimuli. Silicon Dioxide 75-81 C-X-C motif chemokine ligand 8 Homo sapiens 47-50 7546131-6 1995 Results of studies have varied, but the largest ever double-blind NaF/SMFP head-to-head dentifrice trial yet published (Stephen et al., 1994) has indicated a 6.4% significant benefit in favor of NaF (in silica) over SMFP. Silicon Dioxide 203-209 C-X-C motif chemokine ligand 8 Homo sapiens 195-198 7546131-8 1995 In relation to root caries, Jensen and Kohout (1988) reported a 41.4% DFS significant reduction in subjects who used a NaF/silica dentifrice at 1100 ppm F, over a one-year period. Silicon Dioxide 123-129 C-X-C motif chemokine ligand 8 Homo sapiens 119-122 8624224-9 1995 The following can be concluded from this study: 1) silica based dentifrices containing MFP and NaF are effective at remineralizing caries-like lesions in both enamel and dentin; 2) there was no statistical difference between NaF and MFP in their ability to promote remineralization; and 3) pyrophosphate does not interfere with the remineralizing effects of NaF. Silicon Dioxide 51-57 C-X-C motif chemokine ligand 8 Homo sapiens 95-98 8138326-4 1993 In the recent past, meta-analytic techniques employed on data concerning > 14,000 clinical trial subjects from 12 studies, have established that the use of NaF in a correctly formulated silica base provides superior caries protection than does either an NaF + SMFP, or SMFP dentifrice. Silicon Dioxide 189-195 C-X-C motif chemokine ligand 8 Homo sapiens 159-162 33379200-8 2020 Both iron oxide and silica enhanced LPS-induced production of TNF-alpha, IL-1beta, IL-6 and IL-8 in THP-1 cells with most of these responses replicated in PBMCs. Silicon Dioxide 20-26 C-X-C motif chemokine ligand 8 Homo sapiens 92-96 34172787-9 2021 IL-8, alpha1AT, ferritin, CRP and LDH levels were higher in silicosis than in those exposed to silica without silicosis. Silicon Dioxide 95-101 C-X-C motif chemokine ligand 8 Homo sapiens 0-4 2732364-7 1989 Silica was inert in binding and inactivating F of NaF and Na2PO3F (MFP). Silicon Dioxide 0-6 C-X-C motif chemokine ligand 8 Homo sapiens 50-53 8841435-4 1996 Antibodies to IL-1 alpha, IL-8, and TGF beta 1 showed intense staining in silica-injured lungs as compared to saline-instilled lungs. Silicon Dioxide 74-80 C-X-C motif chemokine ligand 8 Homo sapiens 26-30 2059236-5 1991 In addition, an IL-8-specific antibody markedly inhibited the neutrophil-activating capacity of the conditioned media from monocytes activated by urate crystals, as well as by inflammatory silica crystals. Silicon Dioxide 189-195 C-X-C motif chemokine ligand 8 Homo sapiens 16-20