PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28177948-3 2017 Although the importance of the NACHT, LRR and PYD domains-containing protein 3 (NALP3) inflammasome as the initial immune reaction against silica particles has been identified, the mechanisms involved that lead to various autoimmune diseases in patients exposed to silica remain largely unknown. Silicon Dioxide 139-145 NLR family pyrin domain containing 3 Homo sapiens 31-78 28177948-3 2017 Although the importance of the NACHT, LRR and PYD domains-containing protein 3 (NALP3) inflammasome as the initial immune reaction against silica particles has been identified, the mechanisms involved that lead to various autoimmune diseases in patients exposed to silica remain largely unknown. Silicon Dioxide 139-145 NLR family pyrin domain containing 3 Homo sapiens 80-85 28177948-3 2017 Although the importance of the NACHT, LRR and PYD domains-containing protein 3 (NALP3) inflammasome as the initial immune reaction against silica particles has been identified, the mechanisms involved that lead to various autoimmune diseases in patients exposed to silica remain largely unknown. Silicon Dioxide 265-271 NLR family pyrin domain containing 3 Homo sapiens 80-85 23402370-0 2013 Silica induces NLRP3 inflammasome activation in human lung epithelial cells. Silicon Dioxide 0-6 NLR family pyrin domain containing 3 Homo sapiens 15-20 25486008-4 2014 METHODS AND RESULTS: IFNT dose-dependently inhibited IL-1beta secretion induced by nano-silica, a well-known activators of NLRP3 inflammasomes, in human macrophages primed with lipopolysaccharide (LPS, TLR4 agonist) and Pam3CSK4 (TLR1/2 agonist). Silicon Dioxide 88-94 NLR family pyrin domain containing 3 Homo sapiens 123-128 26114647-5 2015 The NLRP3 inflammasome has been shown to be of pivotal importance in the detection of danger molecules such as inorganic crystals like asbestos, silica and malarial hemozoin, (HZ) as well as infectious agents. Silicon Dioxide 145-151 NLR family pyrin domain containing 3 Homo sapiens 4-9 25654762-2 2015 Widely used nano-sized inorganic metal oxides such as silica dioxide (nano-SiO2) and titanium dioxide (nano-TiO2) activate the NLRP3 inflammasome in macrophages similarly to silica or asbestos micro-sized particles. Silicon Dioxide 75-79 NLR family pyrin domain containing 3 Homo sapiens 127-132 25654762-2 2015 Widely used nano-sized inorganic metal oxides such as silica dioxide (nano-SiO2) and titanium dioxide (nano-TiO2) activate the NLRP3 inflammasome in macrophages similarly to silica or asbestos micro-sized particles. Silicon Dioxide 54-60 NLR family pyrin domain containing 3 Homo sapiens 127-132 25445147-4 2014 Silica and monosodium urate crystal-treated macrophages with undisturbed lysosomes demonstrated strong co-localization of ASC and Caspase-1, indicative of NLRP3 inflammasome activation. Silicon Dioxide 0-6 NLR family pyrin domain containing 3 Homo sapiens 155-160 23402370-10 2013 CONCLUSION: Our novel data indicate the presence and functional activation of the NLRP3 inflammasome by crystalline silica in human lung epithelial cells, which prolongs an inflammatory signal and affects fibroblast proliferation, mediating a cadre of lung diseases. Silicon Dioxide 116-122 NLR family pyrin domain containing 3 Homo sapiens 82-87 22924492-6 2012 Hydrogen-bonding and electrostatic interactions of the silanol surfaces of fumed silica aggregates with the extracellular plasma membrane cause membrane perturbations sensed by the Nalp3 inflammasome, whose subsequent activation leads to secretion of the cytokine IL-1beta. Silicon Dioxide 81-87 NLR family pyrin domain containing 3 Homo sapiens 181-186 21936977-2 2011 Endogenous and exogenous danger signals, e.g. DNA- and RNA-fragments, urate- and cholesterol crystals, silica and asbestos, ss-amyloid, UV-light and skin irritants, may induce NOD-like receptor protein (NLRP)3 inflammasomes. Silicon Dioxide 103-109 NLR family pyrin domain containing 3 Homo sapiens 203-209 22534002-3 2012 Phagocytosis of crystalline silica in the lung causes lysosomal damage, activating the NALP3 inflammasome and triggering the inflammatory cascade with subsequent fibrosis. Silicon Dioxide 28-34 NLR family pyrin domain containing 3 Homo sapiens 87-92 21126439-0 2010 [Progress in research on role of inflammasome Nalp3 in silica dusts induced body injuries]. Silicon Dioxide 55-61 NLR family pyrin domain containing 3 Homo sapiens 46-51 21596183-2 2011 Cryopyrin recruits different adaptor and effectors proteins into a cytosolic macromolecular complex termed Nalp3-inflammasome, which senses both several pathogen-associated and damage-associated molecular patterns as well as inorganic particles (asbestos, silica), and triggers innate immune and inflammatory responses. Silicon Dioxide 256-262 NLR family pyrin domain containing 3 Homo sapiens 0-9 21596183-2 2011 Cryopyrin recruits different adaptor and effectors proteins into a cytosolic macromolecular complex termed Nalp3-inflammasome, which senses both several pathogen-associated and damage-associated molecular patterns as well as inorganic particles (asbestos, silica), and triggers innate immune and inflammatory responses. Silicon Dioxide 256-262 NLR family pyrin domain containing 3 Homo sapiens 107-112 20561679-0 2010 The effect of surface modification of amorphous silica particles on NLRP3 inflammasome mediated IL-1beta production, ROS production and endosomal rupture. Silicon Dioxide 48-54 NLR family pyrin domain containing 3 Homo sapiens 68-73 20561679-7 2010 Our results reveal a part of NLRP3 activation pathway and provide basic information that should help to create safe and effective forms of SPs. Silicon Dioxide 139-142 NLR family pyrin domain containing 3 Homo sapiens 29-34 34969174-0 2022 The interplay between ASMase signaling pathway and NLRP3 in the epithelial to mesenchymal transition of HBE cells induced by silica. Silicon Dioxide 125-131 NLR family pyrin domain containing 3 Homo sapiens 51-56 19633559-4 2009 In particular, nalp3 mediated inflammasome activation of caspase-1 and conversion of pro-IL-1 to IL-1 play a key role in silica-mediated and bleomycin-mediated pulmonary fibrosis. Silicon Dioxide 121-127 NLR family pyrin domain containing 3 Homo sapiens 15-20 19542372-0 2009 Cutting edge: TNF-alpha mediates sensitization to ATP and silica via the NLRP3 inflammasome in the absence of microbial stimulation. Silicon Dioxide 58-64 NLR family pyrin domain containing 3 Homo sapiens 73-78 34864055-7 2022 We report that the lysosomal cysteine protease cathepsin Z potentiates the development of inflammation associated with respiratory silicosis by augmenting NLRP3 inflammasome-derived IL-1beta expression in response to silica. Silicon Dioxide 217-223 NLR family pyrin domain containing 3 Homo sapiens 155-160 34969174-4 2022 However, whether ASMase and NLRP3 are involved in regulating SiO2 -induced EMT has not been confirmed. Silicon Dioxide 61-65 NLR family pyrin domain containing 3 Homo sapiens 28-33 34969174-7 2022 The ASMase inhibitor desipramine decreased the level of S1P and the expression of alpha-smooth muscle actin (alpha-SMA) and NLRP3 in SiO2 dust-stained HBE cells, whereas the expression of E-cadherin (E-cad) increased. Silicon Dioxide 133-137 NLR family pyrin domain containing 3 Homo sapiens 124-129 34969174-8 2022 The NLRP3 inhibitor MCC950 inhibited the secretion of interleukin-1beta (IL-1beta) and decreased the expression of NLRP3, Caspase-1, and alpha-SMA in SiO2 dust-stained HBE cells, whereas E-cad expression increased and ASMase activity and S1P levels decreased. Silicon Dioxide 150-154 NLR family pyrin domain containing 3 Homo sapiens 4-9 34969174-10 2022 Inhibition of ASMase activity or NLRP3 expression reduced the SiO2 dust-induced cell inflammatory response and slowed the occurrence of EMT in HBE cells. Silicon Dioxide 62-66 NLR family pyrin domain containing 3 Homo sapiens 33-38 34969174-11 2022 Therefore, NLRP3 and ASMase may interact in SiO2 dust-induced EMT in HBE cells. Silicon Dioxide 44-48 NLR family pyrin domain containing 3 Homo sapiens 11-16 18604214-0 2008 Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Silicon Dioxide 0-6 NLR family pyrin domain containing 3 Homo sapiens 48-53 18604214-4 2008 Here we demonstrate that silica and aluminum salt crystals activated inflammasomes formed by the cytoplasmic receptor NALP3. Silicon Dioxide 25-31 NLR family pyrin domain containing 3 Homo sapiens 118-123 18577586-3 2008 Here we show that the inflammatory response and subsequent development of pulmonary fibrosis after inhalation of silica is dependent on the Nalp3 inflammasome. Silicon Dioxide 113-119 NLR family pyrin domain containing 3 Homo sapiens 140-145 18577586-4 2008 Stimulation of macrophages with silica results in the activation of caspase-1 in a Nalp3-dependent manner. Silicon Dioxide 32-38 NLR family pyrin domain containing 3 Homo sapiens 83-88 18577586-5 2008 Macrophages deficient in components of the Nalp3 inflammasome were incapable of secreting the proinflammatory cytokines interleukin (IL)-1beta and IL-18 in response to silica. Silicon Dioxide 168-174 NLR family pyrin domain containing 3 Homo sapiens 43-48 18577586-7 2008 Activation of the Nalp3 inflammasome by silica required both an efflux of intracellular potassium and the generation of reactive oxygen species. Silicon Dioxide 40-46 NLR family pyrin domain containing 3 Homo sapiens 18-23 34766707-3 2022 We isolated primary AEC from three healthy adults and treated them with silica particles at different concentrations for 48 h. We found evidence for silica-induced inflammasome activation by the co-localization of Caspase-1 and NLRP3, as well as increased levels of IL-1beta and IL-18. Silicon Dioxide 72-78 NLR family pyrin domain containing 3 Homo sapiens 228-233 34766707-3 2022 We isolated primary AEC from three healthy adults and treated them with silica particles at different concentrations for 48 h. We found evidence for silica-induced inflammasome activation by the co-localization of Caspase-1 and NLRP3, as well as increased levels of IL-1beta and IL-18. Silicon Dioxide 149-155 NLR family pyrin domain containing 3 Homo sapiens 228-233 34766707-8 2022 These data suggest that microcrystalline silica can induce significant inflammation and pyroptosis in human primary AEC through NLRP3 inflammasome pathway and NF-kappaB signaling pathway at both the gene and protein levels, and the possible mechanism could be miR-455-3p mediated ceRNA hypothesis. Silicon Dioxide 41-47 NLR family pyrin domain containing 3 Homo sapiens 128-133 35219847-0 2022 Silica nanoparticles induce pyroptosis and cardiac hypertrophy via ROS/NLRP3/Caspase-1 pathway. Silicon Dioxide 0-6 NLR family pyrin domain containing 3 Homo sapiens 71-76 34336106-0 2021 The Ameliorative Effects of Arctiin and Arctigenin on the Oxidative Injury of Lung Induced by Silica via TLR-4/NLRP3/TGF-beta Signaling Pathway. Silicon Dioxide 94-100 NLR family pyrin domain containing 3 Homo sapiens 111-116 34336106-3 2021 Further, our study revealed that arctiin and arctigenin suppressed the activation of NLRP3 inflammasome through the TLR-4/Myd88/NF-kappaB pathway and the silica-induced secretion of TNF-alpha, IL-1beta, TGF-beta, and alpha-SMA. Silicon Dioxide 154-160 NLR family pyrin domain containing 3 Homo sapiens 85-90 33053467-0 2021 Amorphous silica nanoparticles induce inflammation via activation of NLRP3 inflammasome and HMGB1/TLR4/MYD88/NF-kb signaling pathway in HUVEC cells. Silicon Dioxide 10-16 NLR family pyrin domain containing 3 Homo sapiens 69-74 33012733-9 2020 Additionally, the administration of rCC16 significantly attenuated the increase of pro-IL-1beta, NLRP3 and caspase-1 levels induced by silica particle exposure. Silicon Dioxide 135-141 NLR family pyrin domain containing 3 Homo sapiens 97-102 33144845-5 2020 To address a potential heterogeneity in inflammasome functionality, ATP, chitosan, or silica oxide (SiO2) were used to induce NLRP3 inflammasome activation in THP-1 cells and the subsequent outcomes were quantified. Silicon Dioxide 100-104 NLR family pyrin domain containing 3 Homo sapiens 126-131 29403480-3 2017 Inhalation of crystalline silica can induce inflammation by stimulating the NLRP3 inflammasome, a cytosolic receptor complex that plays a critical role in driving inflammatory immune responses. Silicon Dioxide 26-32 NLR family pyrin domain containing 3 Homo sapiens 76-81 30807742-3 2019 The cathepsins B, C, L, S and Z have been implicated in NLRP3 inflammasome activation following their activation with ATP, monosodium urate, silica crystals, or bacterial components, among others. Silicon Dioxide 141-147 NLR family pyrin domain containing 3 Homo sapiens 56-61 30847537-10 2019 Therefore, fibrogenic CNTs and silica, but not CB, elicit robust macrophage-guided myofibroblast transformation, which depends on the induction of IL-1beta through the NLRP3 inflammasome pathway and the increased production of ROS in macrophages. Silicon Dioxide 31-37 NLR family pyrin domain containing 3 Homo sapiens 168-173 29403480-6 2017 In this study, we target the NLRP3 inflammasome as a crystalline silica responsive element to clarify volcanic cristobalite reactivity. Silicon Dioxide 65-71 NLR family pyrin domain containing 3 Homo sapiens 29-34 28968864-6 2017 Low doses of silica induced NLRP3 activation, DNA damage accumulation, and ATM phosphorylation. Silicon Dioxide 13-19 NLR family pyrin domain containing 3 Homo sapiens 28-33 29113588-0 2017 Silica nanoparticles induce NLRP3 inflammasome activation in human primary immune cells. Silicon Dioxide 0-6 NLR family pyrin domain containing 3 Homo sapiens 28-33 29258746-0 2018 NLRP3 inflammasome inhibition attenuates silica-induced epithelial to mesenchymal transition (EMT) in human bronchial epithelial cells. Silicon Dioxide 41-47 NLR family pyrin domain containing 3 Homo sapiens 0-5 29258746-3 2018 NLRP3 inflammasome is a critical mediator of inflammation in response to a wide range of stimuli (including silica particles), and plays an important role in many respiratory diseases. Silicon Dioxide 108-114 NLR family pyrin domain containing 3 Homo sapiens 0-5 29258746-4 2018 However, whether NLRP3 inflammasome regulates silica-induced EMT remains unknown. Silicon Dioxide 46-52 NLR family pyrin domain containing 3 Homo sapiens 17-22 29258746-6 2018 Meanwhile, silica persistently activated NLRP3 inflammasome as indicated by continuously elevated extracellular levels of interleukin-1beta (IL-1beta) and IL-18. Silicon Dioxide 11-17 NLR family pyrin domain containing 3 Homo sapiens 41-46 29258746-7 2018 NLRP3 inflammasome inhibition by short hairpin RNA (shRNA)-mediated knockdown of NLRP3, selective inhibitor MCC950, and caspase-1 inhibitor Z-YVAD-FMK attenuated silica-induced EMT. Silicon Dioxide 162-168 NLR family pyrin domain containing 3 Homo sapiens 0-5 29258746-7 2018 NLRP3 inflammasome inhibition by short hairpin RNA (shRNA)-mediated knockdown of NLRP3, selective inhibitor MCC950, and caspase-1 inhibitor Z-YVAD-FMK attenuated silica-induced EMT. Silicon Dioxide 162-168 NLR family pyrin domain containing 3 Homo sapiens 81-86 29258746-9 2018 Moreover, pirfenidone, a commercially and clinically available drug approved for treating idiopathic pulmonary fibrosis (IPF), effectively suppressed silica-induced EMT of 16HBE cells in line with NLRP3 inflammasome inhibition. Silicon Dioxide 150-156 NLR family pyrin domain containing 3 Homo sapiens 197-202