PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12794155-4	2003	The tyrosine kinase inhibitor herbimycin blocked Ad19-induced IL-8 expression.	herbimycin	30-40	C-X-C motif chemokine ligand 8	Homo sapiens	62-66	
16678783-5	2006	The stimulatory effect of EGF on IL-1beta-induced IL-8 production was completely abolished by the broad range tyrosine kinase inhibitor Herbimycin A, and considerably reduced by the receptor tyrosine kinase specific inhibitor PD 153035.	herbimycin	136-148	C-X-C motif chemokine ligand 8	Homo sapiens	50-54	
16678783-6	2006	Herbimycin A abolished IL-8 production induced by IL-1beta, whereas PD 153035 had no effect on the cytokine-induced IL-8 production.	herbimycin	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	23-27	
19220840-7	2009	In addition, herbimycin A, a specific inhibitor of heat shock protein 90 (Hsp90), decreased the BFT-induced activation of IKK and NF-kappaB, suggesting that Hsp90 is associated with a pathway of IKK-NF-kappaB-IL-8/cyclo-oxygenase-2 gene signalling.	herbimycin	13-25	C-X-C motif chemokine ligand 8	Homo sapiens	209-213	
17895603-8	2007	The Sophy beta-glucan-induced production of IL-8 in the U937 cells was significantly (P<0.01) blocked by the conventional protein kinase C (PKC) inhibitor Go6976, the novel PKC inhibitor Rottlerin, the protein kinase A (PKA) inhibitor H-89, and the protein tyrosine kinase (PTK) inhibitor herbimycin A.	herbimycin	292-304	C-X-C motif chemokine ligand 8	Homo sapiens	44-48	
11911801-7	2002	These results were further supported by the fact that treatment of monocytes with herbimycin-A, another well-described inhibitor of PTK activity with a different mechanism of action, significantly diminished the effect of M. bovis on CXCL-8 secretion.	herbimycin	82-94	C-X-C motif chemokine ligand 8	Homo sapiens	234-240	
12697421-7	2003	Induction of IL-8 and MCP-1 was abrogated by Ro318220, an inhibitor of PKC, as well as by genistein or herbimycin A, inhibitors of PTK.	herbimycin	103-115	C-X-C motif chemokine ligand 8	Homo sapiens	13-17	
9182566-7	1997	IL-8 production by OA or VA was inhibited by protein kinase inhibitors, including staurosporine, H-7, K252a, herbimycin A, and genistein.	herbimycin	109-121	C-X-C motif chemokine ligand 8	Homo sapiens	0-4	
10702246-6	2000	Treatment of SK-OV-3 cells with the inhibitors genestein and herbimycin A indicated that tyrosine kinases were involved in the IL-8 activation of Erk1 and Erk2.	herbimycin	61-73	C-X-C motif chemokine ligand 8	Homo sapiens	127-131	
10417153-5	1999	Further studies with the L5F11 cell line showed that IL-8 gene transcription induced by H. pylori was blocked by the protein tyrosine kinase inhibitor herbimycin A but not by the protein kinase C inhibitor calphostin C or by the protein kinase G inhibitor KT5823.	herbimycin	151-163	C-X-C motif chemokine ligand 8	Homo sapiens	53-57	
8969274-8	1996	IL-8 secretion was also suppressed by staurosporine, an inhibitor of protein kinase C, and by inhibitors of tyrosine kinase such as herbimycin A and genistein.	herbimycin	132-144	C-X-C motif chemokine ligand 8	Homo sapiens	0-4	
7875467-8	1995	However, induction of IL-8 by IL-1 beta or TNF-alpha was reduced by the PTK inhibitors herbimycin (by 79% or 89%, respectively) and genistein (by > 95%).	herbimycin	87-97	C-X-C motif chemokine ligand 8	Homo sapiens	22-26	
7812007-7	1995	The formation of PEt stimulated by IL-8 was inhibited by pertussis toxin and the tyrosine kinase inhibitors erbstatin and herbimycin A.	herbimycin	122-134	C-X-C motif chemokine ligand 8	Homo sapiens	35-39