PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11911801-7 2002 These results were further supported by the fact that treatment of monocytes with herbimycin-A, another well-described inhibitor of PTK activity with a different mechanism of action, significantly diminished the effect of M. bovis on CXCL-8 secretion. herbimycin 82-94 C-X-C motif chemokine ligand 8 Homo sapiens 234-240 17895603-8 2007 The Sophy beta-glucan-induced production of IL-8 in the U937 cells was significantly (P<0.01) blocked by the conventional protein kinase C (PKC) inhibitor Go6976, the novel PKC inhibitor Rottlerin, the protein kinase A (PKA) inhibitor H-89, and the protein tyrosine kinase (PTK) inhibitor herbimycin A. herbimycin 292-304 C-X-C motif chemokine ligand 8 Homo sapiens 44-48 16678783-5 2006 The stimulatory effect of EGF on IL-1beta-induced IL-8 production was completely abolished by the broad range tyrosine kinase inhibitor Herbimycin A, and considerably reduced by the receptor tyrosine kinase specific inhibitor PD 153035. herbimycin 136-148 C-X-C motif chemokine ligand 8 Homo sapiens 50-54 16678783-6 2006 Herbimycin A abolished IL-8 production induced by IL-1beta, whereas PD 153035 had no effect on the cytokine-induced IL-8 production. herbimycin 0-12 C-X-C motif chemokine ligand 8 Homo sapiens 23-27 12794155-4 2003 The tyrosine kinase inhibitor herbimycin blocked Ad19-induced IL-8 expression. herbimycin 30-40 C-X-C motif chemokine ligand 8 Homo sapiens 62-66 19220840-7 2009 In addition, herbimycin A, a specific inhibitor of heat shock protein 90 (Hsp90), decreased the BFT-induced activation of IKK and NF-kappaB, suggesting that Hsp90 is associated with a pathway of IKK-NF-kappaB-IL-8/cyclo-oxygenase-2 gene signalling. herbimycin 13-25 C-X-C motif chemokine ligand 8 Homo sapiens 209-213 12697421-7 2003 Induction of IL-8 and MCP-1 was abrogated by Ro318220, an inhibitor of PKC, as well as by genistein or herbimycin A, inhibitors of PTK. herbimycin 103-115 C-X-C motif chemokine ligand 8 Homo sapiens 13-17 9182566-7 1997 IL-8 production by OA or VA was inhibited by protein kinase inhibitors, including staurosporine, H-7, K252a, herbimycin A, and genistein. herbimycin 109-121 C-X-C motif chemokine ligand 8 Homo sapiens 0-4 10417153-5 1999 Further studies with the L5F11 cell line showed that IL-8 gene transcription induced by H. pylori was blocked by the protein tyrosine kinase inhibitor herbimycin A but not by the protein kinase C inhibitor calphostin C or by the protein kinase G inhibitor KT5823. herbimycin 151-163 C-X-C motif chemokine ligand 8 Homo sapiens 53-57 10702246-6 2000 Treatment of SK-OV-3 cells with the inhibitors genestein and herbimycin A indicated that tyrosine kinases were involved in the IL-8 activation of Erk1 and Erk2. herbimycin 61-73 C-X-C motif chemokine ligand 8 Homo sapiens 127-131 8969274-8 1996 IL-8 secretion was also suppressed by staurosporine, an inhibitor of protein kinase C, and by inhibitors of tyrosine kinase such as herbimycin A and genistein. herbimycin 132-144 C-X-C motif chemokine ligand 8 Homo sapiens 0-4 7812007-7 1995 The formation of PEt stimulated by IL-8 was inhibited by pertussis toxin and the tyrosine kinase inhibitors erbstatin and herbimycin A. herbimycin 122-134 C-X-C motif chemokine ligand 8 Homo sapiens 35-39 7875467-8 1995 However, induction of IL-8 by IL-1 beta or TNF-alpha was reduced by the PTK inhibitors herbimycin (by 79% or 89%, respectively) and genistein (by > 95%). herbimycin 87-97 C-X-C motif chemokine ligand 8 Homo sapiens 22-26