PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31100859-2	2019	The glycosaminoglycan heparin, widely used as a clinical anticoagulant, has previously been shown to inhibit the Alzheimer"s disease-relevant beta-secretase 1 (BACE1).	Heparin	22-29	beta-secretase 1	Homo sapiens	160-165	
17004727-0	2006	Heparin derivatives as inhibitors of BACE-1, the Alzheimer"s beta-secretase, with reduced activity against factor Xa and other proteases.	Heparin	0-7	beta-secretase 1	Homo sapiens	37-43	
27474542-0	2016	Low anticoagulant heparin oligosaccharides as inhibitors of BACE-1, the Alzheimer"s beta-secretase.	Heparin	18-25	beta-secretase 1	Homo sapiens	60-66	
18322389-4	2008	METHODS: We tested a number of selectively desulphated and chemically modified heparins for their ability to inhibit BACE1 and other proteases in vitro using APP fluorescent resonance energy transfer peptide substrates RESULTS: Several lead compounds have been identified that are effective beta-secretase inhibitors, but have negligible activity as anticoagulants or as inhibitors of other aspartyl proteases structurally related to beta-secretase.	Heparin	79-87	beta-secretase 1	Homo sapiens	117-122	
14530380-3	2003	We show that HS and heparin interact directly with BACE1 and inhibit in vitro processing of peptide and APP substrates.	Heparin	20-27	beta-secretase 1	Homo sapiens	51-56	
16716081-0	2006	Heparin activates beta-secretase (BACE1) of Alzheimer"s disease and increases autocatalysis of the enzyme.	Heparin	0-7	beta-secretase 1	Homo sapiens	34-39	
16716081-5	2006	However, heparin has also been reported to directly inhibit BACE1 activity in vitro.	Heparin	9-16	beta-secretase 1	Homo sapiens	60-65	
16716081-6	2006	To clarify the role of heparin in regulating BACE1, we examined the effect of heparin on the activity of recombinant human BACE1 (rBACE1) in vitro.	Heparin	78-85	beta-secretase 1	Homo sapiens	123-128	
16716081-9	2006	Heparin affinity chromatography demonstrated that heparin interacted strongly with the zymogen form of rBACE1 and bound to a peptide homologous to the N-terminal pro sequence of BACE1.	Heparin	0-7	beta-secretase 1	Homo sapiens	104-109	
16716081-9	2006	Heparin affinity chromatography demonstrated that heparin interacted strongly with the zymogen form of rBACE1 and bound to a peptide homologous to the N-terminal pro sequence of BACE1.	Heparin	50-57	beta-secretase 1	Homo sapiens	104-109	
16716081-12	2006	Our results strongly suggest that heparin stimulates the partially active BACE1 zymogen, and we propose that the activation is mediated by high-affinity binding of heparin to the pro domain.	Heparin	34-41	beta-secretase 1	Homo sapiens	74-79	
16716081-12	2006	Our results strongly suggest that heparin stimulates the partially active BACE1 zymogen, and we propose that the activation is mediated by high-affinity binding of heparin to the pro domain.	Heparin	164-171	beta-secretase 1	Homo sapiens	74-79