PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12079941-2	2002	Heparin-coated circuits with a centrifugal pump provided 2.5 to 3.5 L x min(-1) of flow to maintain good hemodynamics and enable easy access to the posterior vessels during vertical displacement of the heart.	Heparin	0-7	CD59 molecule (CD59 blood group)	Homo sapiens	72-78	
579513-5	1977	Namely, at 4.5 x 10(-6)M, 9 x 10(-6)M, 1.8 x 10(-5)M and 3.6 x 10(-5)M heparin concentrations, the rate constants were 0.27 min -1, 0.17 min-1, 0.11 min-1 and 0.06 min-1, respectively.	Heparin	71-78	CD59 molecule (CD59 blood group)	Homo sapiens	137-142	
579513-5	1977	Namely, at 4.5 x 10(-6)M, 9 x 10(-6)M, 1.8 x 10(-5)M and 3.6 x 10(-5)M heparin concentrations, the rate constants were 0.27 min -1, 0.17 min-1, 0.11 min-1 and 0.06 min-1, respectively.	Heparin	71-78	CD59 molecule (CD59 blood group)	Homo sapiens	149-154	
579513-5	1977	Namely, at 4.5 x 10(-6)M, 9 x 10(-6)M, 1.8 x 10(-5)M and 3.6 x 10(-5)M heparin concentrations, the rate constants were 0.27 min -1, 0.17 min-1, 0.11 min-1 and 0.06 min-1, respectively.	Heparin	71-78	CD59 molecule (CD59 blood group)	Homo sapiens	149-154	
19968085-3	2009	At the background of administration of the heparin at a dose of 0.2-0.3 U x kg(-1) min(-1), urokinase was intravenously administered with a loading dose of 15-20 U x kg(-1) x min(-1) and a locked time period of 30 minutes, and then the dose was incessantly decreased to 4-10 U x kg(-1) x min(-1).	Heparin	43-50	CD59 molecule (CD59 blood group)	Homo sapiens	83-89	
12492611-9	2002	The TFPI release rate rapidly increased to maximum of 200 +/- 45 micro g min-1 after 17.5 min heparin infusion but did not increase further although heparin concentrations further doubled.	Heparin	94-101	CD59 molecule (CD59 blood group)	Homo sapiens	73-78	
8746633-9	1995	In the presence of glycosaminoglycans, the maximal thrombin inhibition rate (k2 x 10(-3) M-1 min-1) for rHCII was 10.4 +/- 2.5 at 100 micrograms/ml heparin and 16.0 +/- 4.3 at 1000 micrograms/ml dermatan sulfate compared to 9.0 +/- 0.7 at 200 micrograms/ml heparin and 18.5 +/- 5.3 at 1000 micrograms/ml dermatan sulfate for pHCII.	Heparin	148-155	CD59 molecule (CD59 blood group)	Homo sapiens	93-98	
8746633-9	1995	In the presence of glycosaminoglycans, the maximal thrombin inhibition rate (k2 x 10(-3) M-1 min-1) for rHCII was 10.4 +/- 2.5 at 100 micrograms/ml heparin and 16.0 +/- 4.3 at 1000 micrograms/ml dermatan sulfate compared to 9.0 +/- 0.7 at 200 micrograms/ml heparin and 18.5 +/- 5.3 at 1000 micrograms/ml dermatan sulfate for pHCII.	Heparin	257-264	CD59 molecule (CD59 blood group)	Homo sapiens	93-98	
8429040-7	1993	For inhibition by antithrombin III with heparin, the rate constant was 4.5 x 10(8) M-1 min-1 for wild-type thrombin with no significant differences between any of the recombinant thrombins.	Heparin	40-47	CD59 molecule (CD59 blood group)	Homo sapiens	87-92	
8429040-8	1993	In contrast, the rate constant for inhibition by heparin cofactor II without glycosaminoglycan was 4.3 x 10(4) M-1 min-1 for wild-type thrombin; rates were 10-fold slower for thrombin K52E and 2- to 3-fold slower for thrombins R68E and R70E.	Heparin	49-56	CD59 molecule (CD59 blood group)	Homo sapiens	115-120	
8429040-9	1993	The rate constants for inhibition of wild-type thrombin by HCII in the presence of heparin or dermatan sulfate were 9.2 x 10(8) M-1 min-1 and 9.0 x 10(8) M-1 min-1, respectively.	Heparin	83-90	CD59 molecule (CD59 blood group)	Homo sapiens	132-137	
1740413-4	1992	Interestingly, in the presence of glycosaminoglycans the maximal inhibition rate constants by HC with heparin and dermatan sulfate, respectively, were as follows: 30.0 x 10(7) and 60.5 x 10(7) for alpha-thrombin, 14.6 x 10(7) and 24.3 x 10(7) for epsilon-thrombin, and 0.017 x 10(7) and 0.034 x 10(7) M-1 min-1 for gamma T-thrombin.	Heparin	102-109	CD59 molecule (CD59 blood group)	Homo sapiens	305-310	
1597230-2	1992	A clinically relevant attenuation of the anticoagulant effect of a heparin bolus (40 U.kg-1) by a concomitant infusion of nitroglycerin (100 micrograms.min-1) was absent.	Heparin	67-74	CD59 molecule (CD59 blood group)	Homo sapiens	152-157	
2852498-7	1988	The inhibition rate of APC by PCI (k: 7.5 x 10(5) M-1 min-1) is significantly increased in the presence of 5 i.u./ml heparin (kH: 2.2 x 10(7) M-1 min-1).	Heparin	117-124	CD59 molecule (CD59 blood group)	Homo sapiens	54-59	
2852498-7	1988	The inhibition rate of APC by PCI (k: 7.5 x 10(5) M-1 min-1) is significantly increased in the presence of 5 i.u./ml heparin (kH: 2.2 x 10(7) M-1 min-1).	Heparin	117-124	CD59 molecule (CD59 blood group)	Homo sapiens	146-151	
6687888-5	1983	The second order rate constant for the thrombin-HCII reaction reached a maximum value of 6.4 X 10(8) M-1 min-1 in the presence of 250-500 micrograms/ml of dermatan sulfate compared to 3.8 X 10(8) M-1 min-1 in the presence of 40-80 micrograms/ml of heparin.	Heparin	248-255	CD59 molecule (CD59 blood group)	Homo sapiens	105-110	
1665467-2	1991	We define a standard independent unit (SIU) of heparin as that amount that, in plasma containing 1 mumol of ATIII, raises the (pseudo-)first-order breakdown constant of factor Xa by 1 min-1.	Heparin	47-54	CD59 molecule (CD59 blood group)	Homo sapiens	184-189	
2165828-8	1990	While neutralization of in situ generated factor IXa in normal plasma was negligible, unfractionated heparin dramatically enhanced the rate of inactivation of factor IXa (apparent second order rate constant of inhibition of 5.2 min-1/per microgram heparin/mL).	Heparin	101-108	CD59 molecule (CD59 blood group)	Homo sapiens	228-233	
2165828-9	1990	The synthetic pentasaccharide heparin, the smallest heparin chain capable of binding antithrombin III, stimulated the inhibition of in situ generated factor IXa, but sevenfold less than unfractionated heparin (k = 0.76 min-1 per microgram pentasaccharide/mL).	Heparin	30-37	CD59 molecule (CD59 blood group)	Homo sapiens	219-224	
2432675-3	1986	The maximum second order rate constant of heparin cofactor II-thrombin reaction in the presence of the fractions of over-10 kDa and 18% sulfur was 2.7 X 10(8) M-1 min-1 that was almost same as in the presence of heparin or dermatan sulfate.	Heparin	42-49	CD59 molecule (CD59 blood group)	Homo sapiens	163-168	
2432675-3	1986	The maximum second order rate constant of heparin cofactor II-thrombin reaction in the presence of the fractions of over-10 kDa and 18% sulfur was 2.7 X 10(8) M-1 min-1 that was almost same as in the presence of heparin or dermatan sulfate.	Heparin	212-219	CD59 molecule (CD59 blood group)	Homo sapiens	163-168	
3790498-6	1986	The first-order rate constants of these reactions at 200 nM antithrombin III and normalized to heparin at 1 microgram/mL were 0.33 and 9.5 min-1 in the presence and absence of factor Va and phospholipid, respectively.	Heparin	95-102	CD59 molecule (CD59 blood group)	Homo sapiens	139-144	
6895893-8	1982	The second-order rate constant for inhibition of thrombin by purified HCII increases from 5.0 X 10(5) M-1 min-1 in the absence of heparin to 4.5 x 10(8) M-1 min-1 at optimal heparin concentrations of 0.8 to 1.0 unit/ml.	Heparin	174-181	CD59 molecule (CD59 blood group)	Homo sapiens	157-162	
6105392-1	1980	When prostacyclin (5 ng kg-1 min-1) was given during dialysis it enhanced the biological activity of heparin and prevented the activation and consumption of platelets.	Heparin	101-108	CD59 molecule (CD59 blood group)	Homo sapiens	29-34