PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18669635-6 2008 Heparin disrupted tropoelastin binding but did not disrupt N- and C-terminal fibrillin-1 interactions. Heparin 0-7 elastin Homo sapiens 18-30 24148803-7 2014 In parallel experiments heparin was shown to have minor inhibitory effects on fibulin-5 interactions with tropoelastin and LTBP-2. Heparin 24-31 elastin Homo sapiens 106-118 24148803-8 2014 However, LTBP-2 was shown to significantly inhibit the binding of heparin to tropoelastin with 50% inhibition achieved with 10 fold molar excess of LTBP-2. Heparin 66-73 elastin Homo sapiens 77-89 23844507-2 2013 The impurities of aromatic aminoacids Phe, Tyr and elastin protein was revealed in drug of heparin. Heparin 91-98 elastin Homo sapiens 51-58 21600981-7 2011 These findings indicate that heparinized vascular grafts may promote elastin formation and regulate restenosis, in addition to heparin"s well-established antithrombotic properties. Heparin 29-36 elastin Homo sapiens 69-76 21600981-8 2011 Given the increase in elastin mRNA level and the increase in extracellular elastin present, our data suggests that there may be multiple levels of elastin regulation that are mediated by heparin treatment. Heparin 187-194 elastin Homo sapiens 22-29 21600981-8 2011 Given the increase in elastin mRNA level and the increase in extracellular elastin present, our data suggests that there may be multiple levels of elastin regulation that are mediated by heparin treatment. Heparin 187-194 elastin Homo sapiens 75-82 21600981-8 2011 Given the increase in elastin mRNA level and the increase in extracellular elastin present, our data suggests that there may be multiple levels of elastin regulation that are mediated by heparin treatment. Heparin 187-194 elastin Homo sapiens 75-82 20939056-0 2010 Synthetic elastin hydrogels that are coblended with heparin display substantial swelling, increased porosity, and improved cell penetration. Heparin 52-59 elastin Homo sapiens 10-17 20939056-7 2010 Hydrogel swelling studies showed that each of the hydrogels contracted as the temperature was raised from 4 C to 37 C; synthetic elastin-heparin was least affected by temperature with a contraction of only 22.4 +- 1.2%, which would facilitate its transition from cold storage to body temperature. Heparin 137-144 elastin Homo sapiens 129-136 18547105-3 2008 We found a significant effect, particularly of heparin, on the minimum or critical concentration of tropoelastin, which was required for microassembly, lowering critical concentration to a point that it was no longer detectable. Heparin 47-54 elastin Homo sapiens 100-112 18547105-5 2008 The spherules readily coalesced in the presence of heparin and higher concentrations of tropoelastin, resulting in an almost continuous layer of coacervated tropoelastin. Heparin 51-58 elastin Homo sapiens 157-169 8690721-0 1995 Modulation of elastin expression by heparin is dependent on the growth condition of vascular smooth muscle cells: up-regulation of elastin expression by heparin in the proliferating cells is mediated by the inhibition of protein kinase C activity. Heparin 36-43 elastin Homo sapiens 14-21 8690721-1 1995 The effect of heparin on elastin expression in the proliferating and quiescent phases of growth of smooth muscle cells was studied. Heparin 14-21 elastin Homo sapiens 25-32 8882470-1 1996 Elastin expression in cultured vascular smooth muscle cell (VSMC) was found to be enhanced by potent inhibitors of VSMC proliferation including minoxidil, heparin and retinoic acid. Heparin 155-162 elastin Homo sapiens 0-7 8690721-0 1995 Modulation of elastin expression by heparin is dependent on the growth condition of vascular smooth muscle cells: up-regulation of elastin expression by heparin in the proliferating cells is mediated by the inhibition of protein kinase C activity. Heparin 153-160 elastin Homo sapiens 14-21 8690721-2 1995 Heparin stimulated elastin synthesis and its mRNA level 2-3 fold in the proliferating cells while it inhibited the cell proliferation. Heparin 0-7 elastin Homo sapiens 19-26 8690721-0 1995 Modulation of elastin expression by heparin is dependent on the growth condition of vascular smooth muscle cells: up-regulation of elastin expression by heparin in the proliferating cells is mediated by the inhibition of protein kinase C activity. Heparin 153-160 elastin Homo sapiens 131-138 8690721-3 1995 The inhibition of cell proliferation and the stimulation of elastin expression by heparin in the proliferating cells were mimicked by a potent protein kinase C antagonist, H-7, but not by H-89, W-7, and HA1004, suggesting that the effect of heparin is mediated by the inhibition of protein kinase C. In contrast, heparin inhibited elastin synthesis and its mRNA level slightly but exhibited no effect on cell proliferation in the growth-arrested cells. Heparin 82-89 elastin Homo sapiens 60-67 1777434-0 1991 A lipophilic heparin derivative protects elastin against degradation by leucocyte elastase. Heparin 13-20 elastin Homo sapiens 41-48 8690721-3 1995 The inhibition of cell proliferation and the stimulation of elastin expression by heparin in the proliferating cells were mimicked by a potent protein kinase C antagonist, H-7, but not by H-89, W-7, and HA1004, suggesting that the effect of heparin is mediated by the inhibition of protein kinase C. In contrast, heparin inhibited elastin synthesis and its mRNA level slightly but exhibited no effect on cell proliferation in the growth-arrested cells. Heparin 82-89 elastin Homo sapiens 331-338 8690721-4 1995 This result indicates that heparin reciprocally affects elastin expression depending on the growth state of smooth muscle cells. Heparin 27-34 elastin Homo sapiens 56-63 8690721-5 1995 Heparin thus exerts a complex influence on elastin expression in smooth muscle cells. Heparin 0-7 elastin Homo sapiens 43-50 7899138-11 1994 We synthesized N-oleoyl heparin derivative (3 oleoyl groups/one molecule of heparin); such a lipophilic glycosaminoglycan (LipoGAG), although acting as an elastin protecting agent, possessed lower HNE inhibitory capacity as compared with heparin. Heparin 24-31 elastin Homo sapiens 155-162 1655335-4 1991 Heparin and heparan sulphate also strongly inhibited human leucocyte elastase activity towards insoluble human lung elastin, as determined by an e.l.i.s.a. Heparin 0-7 elastin Homo sapiens 116-123 1655335-9 1991 These results suggest that heparin and heparan sulphate, as components of cellular and basement membranes, are likely to have a role in protecting structural proteins, such as elastin, from the proteolytic activity of human leucocyte elastase. Heparin 27-34 elastin Homo sapiens 176-183 1777434-4 1991 When insoluble elastin is pretreated with I its degradation by leucocyte elastase is inhibited by almost 90% while pretreatment of elastin with heparin exhibited only a moderate effect on elastolysis (10% inhibition). Heparin 144-151 elastin Homo sapiens 131-138 32063701-10 2019 Heparin inhibits collagen crosslinking while stimulating elastin repair and might therefore be the ideal companion of copper for emphysema patients. Heparin 0-7 elastin Homo sapiens 57-64 2900022-7 1988 These results suggest that heparin may modulate the oxidation and thus the insolubilization of extracellular collagen fibers, possibly under conditions where elastin fiber synthesis is not affected, and that the tight binding of lysyl oxidase to collagen is not completely related to the expression of enzyme activity toward this substrate. Heparin 27-34 elastin Homo sapiens 158-165