PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11741940-1	2002	Secreted Frizzled-related protein-1 (sFRP-1), a soluble protein that binds to Wnts and modulates Wnt signaling, contains an N-terminal domain homologous to the putative Wnt-binding site of Frizzled (Fz domain) and a C-terminal heparin-binding domain with weak homology to netrin.	Heparin	227-234	secreted frizzled related protein 1	Homo sapiens	0-35	
17500071-6	2007	We demonstrate that sFRP-1 is post-translationally modified by tyrosine sulfation at tyrosines 34 and 36, which is inhibited by the treatment of heparin.	Heparin	145-152	secreted frizzled related protein 1	Homo sapiens	20-26	
17500071-7	2007	The results suggest that accumulation of sFRP-1 induced by heparin is in part due to the relative stabilization of unsulfated sFRP-1 and the direct stabilization by heparin.	Heparin	59-66	secreted frizzled related protein 1	Homo sapiens	41-47	
17500071-7	2007	The results suggest that accumulation of sFRP-1 induced by heparin is in part due to the relative stabilization of unsulfated sFRP-1 and the direct stabilization by heparin.	Heparin	59-66	secreted frizzled related protein 1	Homo sapiens	126-132	
17500071-7	2007	The results suggest that accumulation of sFRP-1 induced by heparin is in part due to the relative stabilization of unsulfated sFRP-1 and the direct stabilization by heparin.	Heparin	165-172	secreted frizzled related protein 1	Homo sapiens	41-47	
17500071-8	2007	The study has revealed a multifaceted regulation on sFRP-1 protein by heparin.	Heparin	70-77	secreted frizzled related protein 1	Homo sapiens	52-58	
19099244-3	2008	Heparin affinity chromatography is an easy step that provides a major enrichment, particularly for sFRP-1 and sFRP-2.	Heparin	0-7	secreted frizzled related protein 1	Homo sapiens	99-105	
17500071-2	2007	sFRP-1 and Wnts are heparin-binding proteins, and their interaction can be stabilized by heparin in vitro.	Heparin	20-27	secreted frizzled related protein 1	Homo sapiens	0-6	
17500071-3	2007	Here we report that heparin can specifically enhance recombinant sFRP-1 accumulation in a cell type-specific manner.	Heparin	20-27	secreted frizzled related protein 1	Homo sapiens	65-71	
17500071-5	2007	Interestingly, further investigation uncovers that heparin can also affect the post-translational modification of sFRP-1.	Heparin	51-58	secreted frizzled related protein 1	Homo sapiens	114-120	
11741940-1	2002	Secreted Frizzled-related protein-1 (sFRP-1), a soluble protein that binds to Wnts and modulates Wnt signaling, contains an N-terminal domain homologous to the putative Wnt-binding site of Frizzled (Fz domain) and a C-terminal heparin-binding domain with weak homology to netrin.	Heparin	227-234	secreted frizzled related protein 1	Homo sapiens	37-43	
11741940-6	2002	This latter set of assignments provides experimental verification of one of the disulfide patterns proposed for netrin (NTR) modules and thereby supports the prediction that the C-terminal heparin-binding domain of sFRP-1 is an NTR-type domain.	Heparin	189-196	secreted frizzled related protein 1	Homo sapiens	215-221