PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10857760-2 2000 Here, circular dichroism and fluorescence spectroscopic techniques are used to demonstrate that low molecular weight heparin and chondroitin sulfate cause significant changes in secondary and tertiary structure of IFN-gamma. Heparin 117-124 interferon gamma Homo sapiens 214-223 10792372-0 2000 The antagonism of interferon-gamma (IFN-gamma) by heparin: examination of the blockade of class II MHC antigen and heat shock protein-70 expression. Heparin 50-57 interferon gamma Homo sapiens 18-34 10792372-0 2000 The antagonism of interferon-gamma (IFN-gamma) by heparin: examination of the blockade of class II MHC antigen and heat shock protein-70 expression. Heparin 50-57 interferon gamma Homo sapiens 36-45 10792372-6 2000 In this study it is shown that heparin can prevent normal induction of the class II transactivator and heat shock cognate protein-70 in an IFN-gamma-treated endothelial cell line. Heparin 31-38 interferon gamma Homo sapiens 139-148 10792372-8 2000 This provides further evidence for the blockade by heparin of ligand activation of the specific IFN-gamma receptor. Heparin 51-58 interferon gamma Homo sapiens 96-105 10857760-3 2000 The results suggest that heparin and chondroitin sulfate modulate IFN-gamma activity by causing structural changes in the IFN-gamma dimer. Heparin 25-32 interferon gamma Homo sapiens 66-75 10857760-3 2000 The results suggest that heparin and chondroitin sulfate modulate IFN-gamma activity by causing structural changes in the IFN-gamma dimer. Heparin 25-32 interferon gamma Homo sapiens 122-131 9556569-1 1998 Interferon-gamma (IFNgamma), in common with a number of growth factors, binds both to heparan sulfate or heparin-related molecules and to a specific high affinity receptor (IFNgammaR). Heparin 105-112 interferon gamma Homo sapiens 0-16 10818267-11 2000 Also, acidic polysaccharides such as heparin were much more efficacious in the inhibition of hIFN-gamma binding to hemolymph relative to protocerebral particulates. Heparin 37-44 interferon gamma Homo sapiens 93-103 10496308-6 1999 Heparin induced IL-12 and interferon-gamma production but did not promote the release of other cytokines. Heparin 0-7 interferon gamma Homo sapiens 26-42 9825824-1 1998 BACKGROUND: Previously, it has been demonstrated that heparin inhibits major histocompatibility complex (MHC) class II and intercellular adhesion molecule-1 (ICAM-1) expression on interferon-gamma (IFN-gamma)-stimulated human umbilical vein endothelial cells (HUVECs). Heparin 54-61 interferon gamma Homo sapiens 180-196 9825824-1 1998 BACKGROUND: Previously, it has been demonstrated that heparin inhibits major histocompatibility complex (MHC) class II and intercellular adhesion molecule-1 (ICAM-1) expression on interferon-gamma (IFN-gamma)-stimulated human umbilical vein endothelial cells (HUVECs). Heparin 54-61 interferon gamma Homo sapiens 198-207 9825824-3 1998 We also studied whether the degree of sulfation of heparin is of relevance for the binding to IFN-gamma and inhibition of MHC and ICAM-1 expression after IFN-gamma stimulation. Heparin 51-58 interferon gamma Homo sapiens 94-103 9825824-6 1998 RESULTS: Heparin was able to inhibit the up-regulation of MHC and ICAM-1 in a dose-dependent fashion on both IFN-gamma-stimulated HUVECs and PTECs. Heparin 9-16 interferon gamma Homo sapiens 109-118 9825824-8 1998 Heparin and supersulfated glycosaminoglycans (GAGs) were able to bind to IFN-gamma, whereas N-desulfated N-acetylated GAGs with a low amount of sulfate were not. Heparin 0-7 interferon gamma Homo sapiens 73-82 10327605-4 1999 About one-half of [125I]hIFN-gamma binding could be displaced by heparin. Heparin 65-72 interferon gamma Homo sapiens 24-34 9556569-1 1998 Interferon-gamma (IFNgamma), in common with a number of growth factors, binds both to heparan sulfate or heparin-related molecules and to a specific high affinity receptor (IFNgammaR). Heparin 105-112 interferon gamma Homo sapiens 18-26 9556569-6 1998 This binding assay was used to investigate a possible role of heparin in the IFNgamma.IFNgammaR complex formation. Heparin 62-69 interferon gamma Homo sapiens 77-85 9556569-7 1998 In contrast to growth factors for which binding to heparin is usually required for high affinity receptor interaction, we found in this study that IFNgamma bound to heparin displayed a strongly reduced affinity for its receptor. Heparin 51-58 interferon gamma Homo sapiens 147-155 9556569-7 1998 In contrast to growth factors for which binding to heparin is usually required for high affinity receptor interaction, we found in this study that IFNgamma bound to heparin displayed a strongly reduced affinity for its receptor. Heparin 165-172 interferon gamma Homo sapiens 147-155 9556569-9 1998 To understand how a single domain of IFNgamma could be implicated in two discrete functions (i.e. binding to heparin and to IFNgammaR), we also analyzed in a detailed manner the role of the IFNgamma carboxyl-terminal sequence in receptor binding. Heparin 109-116 interferon gamma Homo sapiens 37-45 9556569-10 1998 Using forms of IFNgamma, with carboxyl terminus truncations of defined regions of the heparin binding sequence, we found that the C1 domain functioned by increasing the on rate of the IFNgamma.IFNgammaR binding reaction but was not otherwise required for the stability of the complex. Heparin 86-93 interferon gamma Homo sapiens 15-23 9556569-10 1998 Using forms of IFNgamma, with carboxyl terminus truncations of defined regions of the heparin binding sequence, we found that the C1 domain functioned by increasing the on rate of the IFNgamma.IFNgammaR binding reaction but was not otherwise required for the stability of the complex. Heparin 86-93 interferon gamma Homo sapiens 184-192 9062364-8 1997 Heparin at the concentration that neutralized the function of amphiregulin, or antibodies against TGFalpha or HB-EGF also reduced the release of PGE2 from IFN-gamma-stimulated NHBECs. Heparin 0-7 interferon gamma Homo sapiens 155-164 9191238-0 1997 Heparin modulates endothelial production of monocyte chemotactic peptide-1 following interferon-gamma stimulation. Heparin 0-7 interferon gamma Homo sapiens 85-101 9191239-0 1997 Endothelial cells: heparin modulates the induction of functional antigen presentation by IFN-gamma. Heparin 19-26 interferon gamma Homo sapiens 89-98 9609229-0 1998 Cytokine gene expression in human LPS- and IFNgamma-stimulated mononuclear cells is inhibited by heparin. Heparin 97-104 interferon gamma Homo sapiens 43-51 9609229-3 1998 we studied the effect of heparin on IL-1beta, IL-6 and TNFalpha mRNAs in human lipopolysaccharide-(LPS)- or interferon-gamma(IFN-gamma)-stimulated mononuclear cells. Heparin 25-32 interferon gamma Homo sapiens 108-134 9402691-0 1997 Antigen presentation by endothelium: heparin reduces the immunogenicity of interferon-gamma-treated endothelial cells. Heparin 37-44 interferon gamma Homo sapiens 75-91 9067536-0 1997 Examination of the mechanism by which heparin antagonizes activation of a model endothelium by interferon-gamma (IFN-gamma). Heparin 38-45 interferon gamma Homo sapiens 95-111 9067536-0 1997 Examination of the mechanism by which heparin antagonizes activation of a model endothelium by interferon-gamma (IFN-gamma). Heparin 38-45 interferon gamma Homo sapiens 113-122 9067536-3 1997 Radioligand binding assays demonstrated that total binding of 125I-IFN-gamma to the EAhy.926 endothelial hybridoma cell line was reduced in the presence of heparin or heparan sulphate (HS); the structurally dissimilar GAG chondroitin sulphate had no effect. Heparin 156-163 interferon gamma Homo sapiens 67-76 8663206-0 1996 Heparin decreases the blood clearance of interferon-gamma and increases its activity by limiting the processing of its carboxyl-terminal sequence. Heparin 0-7 interferon gamma Homo sapiens 41-57 8752940-2 1996 In this study, dextran sulfate, a synthetic heparin analogue, was shown to selectively inhibit IFN-gamma-induced surface expression of HLA-DR molecules by human umbilical cord vascular endothelial cells, but not other cytokine-induced molecules such as ELAM-1 or ICAM-1. Heparin 44-51 interferon gamma Homo sapiens 95-104 8663206-1 1996 Interferon-gamma (IFN-gamma) binds with high affinity to heparan sulfate and heparin molecules through its carboxyl-terminal domain. Heparin 77-84 interferon gamma Homo sapiens 0-16 8663206-1 1996 Interferon-gamma (IFN-gamma) binds with high affinity to heparan sulfate and heparin molecules through its carboxyl-terminal domain. Heparin 77-84 interferon gamma Homo sapiens 18-27 8663206-4 1996 When bound to heparin, the plasma clearance of IFN-gamma is decreased greatly (t1/2 = 99 min), and the area under the curve obtained with IFN-gamma alone represented only 15% of that obtained with injected IFN-gamma bound to heparin. Heparin 14-21 interferon gamma Homo sapiens 47-56 8663206-4 1996 When bound to heparin, the plasma clearance of IFN-gamma is decreased greatly (t1/2 = 99 min), and the area under the curve obtained with IFN-gamma alone represented only 15% of that obtained with injected IFN-gamma bound to heparin. Heparin 14-21 interferon gamma Homo sapiens 138-147 8663206-4 1996 When bound to heparin, the plasma clearance of IFN-gamma is decreased greatly (t1/2 = 99 min), and the area under the curve obtained with IFN-gamma alone represented only 15% of that obtained with injected IFN-gamma bound to heparin. Heparin 14-21 interferon gamma Homo sapiens 138-147 8663206-4 1996 When bound to heparin, the plasma clearance of IFN-gamma is decreased greatly (t1/2 = 99 min), and the area under the curve obtained with IFN-gamma alone represented only 15% of that obtained with injected IFN-gamma bound to heparin. Heparin 225-232 interferon gamma Homo sapiens 47-56 8663206-5 1996 Furthermore, the binding of heparin to IFN-gamma limits the extent of its carboxyl-terminal domain degradation to less than 10 amino acids. Heparin 28-35 interferon gamma Homo sapiens 39-48 8663206-7 1996 These data demonstrate that the blood clearance of the cytokine is a non-receptor-mediated process and that in vivo the local concentration of heparan sulfate/heparin-like molecules regulates IFN-gamma activity by a unique mechanism involving a controlled processing of its carboxyl-terminal sequence. Heparin 159-166 interferon gamma Homo sapiens 192-201 8891437-7 1996 Heparin bound to [125I]-IFN-gamma was also used to block the heparan sulfate binding site of the cytokine. Heparin 0-7 interferon gamma Homo sapiens 24-33 8836919-4 1996 We have shown recently that IFN-gamma-mediated effects can be blocked by heparin and that this inhibitory effect can be abrogated by the addition of protamine. Heparin 73-80 interferon gamma Homo sapiens 28-37 8836919-5 1996 In this report, we show that the antagonistic effect of protamine on heparin-mediated inhibition of IFN-gamma activity is mainly due to the capacity of protamine to enhance IFN-gamma activity. Heparin 69-76 interferon gamma Homo sapiens 100-109 8836919-5 1996 In this report, we show that the antagonistic effect of protamine on heparin-mediated inhibition of IFN-gamma activity is mainly due to the capacity of protamine to enhance IFN-gamma activity. Heparin 69-76 interferon gamma Homo sapiens 173-182 8891437-8 1996 In this case, blood clearance and tissue accumulation in the liver and spleen were strongly inhibited, while in the kidney the distribution, but not the accumulation, of [125I]-IFN-gamma was affected by the presence of heparin. Heparin 219-226 interferon gamma Homo sapiens 177-186 7809939-1 1994 Heparin antagonizes the induction of class II MHC molecules by interferon-gamma. Heparin 0-7 interferon gamma Homo sapiens 63-79 7670961-1 1995 The amino acid sequence of interferon gamma (IFN-gamma) has basic amino acid clusters similar to the heparin-binding consensus sequences found in other proteins that bind to proteoglycans (PGs). Heparin 101-108 interferon gamma Homo sapiens 27-54 8744652-4 1995 Recent data indicate that heparin can bind cytokines with potent immune modulatory action (e.g. TNF-alpha, interferon gamma etc.). Heparin 26-33 interferon gamma Homo sapiens 107-123 8603535-4 1996 In this study it is shown that the effects of interferon-gamma (IFN-gamma), but not of tumour necrosis factor-alpha (TNF-alpha), are inhibited by treatment with soluble heparin. Heparin 169-176 interferon gamma Homo sapiens 46-62 8603535-4 1996 In this study it is shown that the effects of interferon-gamma (IFN-gamma), but not of tumour necrosis factor-alpha (TNF-alpha), are inhibited by treatment with soluble heparin. Heparin 169-176 interferon gamma Homo sapiens 64-73 8603535-5 1996 Specifically, heparin was shown to inhibit the induction of class II MHC antigens and the up-regulation of intercellular adhesion molecule-1 (ICAM-1) produced by treatment of cultured human endothelial cells with IFN-gamma. Heparin 14-21 interferon gamma Homo sapiens 213-222 8603535-6 1996 Furthermore, it was shown that heparin blocked the enhanced adhesion of T lymphocytes to IFN-gamma-treated endothelial cells. Heparin 31-38 interferon gamma Homo sapiens 89-98 8603535-8 1996 These results may explain reported immunosuppressive properties of heparin, and are consistent with the model that heparin may compete with cell surface GAGs to bind IFN-gamma, thereby reducing effective biological activity. Heparin 67-74 interferon gamma Homo sapiens 166-175 8603535-8 1996 These results may explain reported immunosuppressive properties of heparin, and are consistent with the model that heparin may compete with cell surface GAGs to bind IFN-gamma, thereby reducing effective biological activity. Heparin 115-122 interferon gamma Homo sapiens 166-175 7705397-0 1995 Heparin inhibits the antiparasitic and immune modulatory effects of human recombinant interferon-gamma. Heparin 0-7 interferon gamma Homo sapiens 86-102 7705397-3 1995 Furthermore, it has been shown that IFN-gamma binds with a great affinity to the heparin-like structure of heparan sulfate, which is localized in basement membranes and on cell surfaces. Heparin 81-88 interferon gamma Homo sapiens 36-45 7705397-4 1995 In this study, we analyze the effect of heparin and heparan sulfate on three different IFN-gamma-mediated activities inducible in human glioblastoma cells (87HG31 and 86HG39). Heparin 40-47 interferon gamma Homo sapiens 87-96 7705397-5 1995 We find firstly that heparin is able to inhibit IFN-gamma-mediated induction of major histocompatibility complex (MHC) class II antigen expression on 87HG31 cells, an effect which can be abrogated by protamine. Heparin 21-28 interferon gamma Homo sapiens 48-57 7705397-6 1995 Secondly, we show that heparin inhibits the IFN-gamma-induced toxoplasmostasis within 86HG39 cells in a dose-dependent fashion, and thirdly that heparin inhibits the IFN-gamma-mediated induction of the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase. Heparin 23-30 interferon gamma Homo sapiens 44-53 7705397-6 1995 Secondly, we show that heparin inhibits the IFN-gamma-induced toxoplasmostasis within 86HG39 cells in a dose-dependent fashion, and thirdly that heparin inhibits the IFN-gamma-mediated induction of the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase. Heparin 23-30 interferon gamma Homo sapiens 166-175 7705397-6 1995 Secondly, we show that heparin inhibits the IFN-gamma-induced toxoplasmostasis within 86HG39 cells in a dose-dependent fashion, and thirdly that heparin inhibits the IFN-gamma-mediated induction of the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase. Heparin 145-152 interferon gamma Homo sapiens 44-53 7705397-6 1995 Secondly, we show that heparin inhibits the IFN-gamma-induced toxoplasmostasis within 86HG39 cells in a dose-dependent fashion, and thirdly that heparin inhibits the IFN-gamma-mediated induction of the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase. Heparin 145-152 interferon gamma Homo sapiens 166-175 7705397-8 1995 The possible mechanism of heparin-induced inhibition of IFN-gamma is discussed. Heparin 26-33 interferon gamma Homo sapiens 56-65 1525174-4 1992 Furthermore, using heparan sulfate and heparin treated with heparinases I and III, we have shown that the interferon-gamma binding sites are localized on the N-sulfated glucosamine rich domains of the molecule. Heparin 39-46 interferon gamma Homo sapiens 106-122 1900310-7 1991 Furthermore, the carboxy-terminal part of the interferon-gamma molecule contains an amino acid cluster, very closely related to a consensus sequence, present in more than 20 proteins known to bind sulfated glycosaminoglycans such as heparin. Heparin 233-240 interferon gamma Homo sapiens 46-62 34639073-1 2021 Our objective is to reveal the molecular mechanism of the anti-inflammatory action of low-molecular-weight heparin (LMWH) based on its influence on the activity of two key cytokines, IFNgamma and IL-6. Heparin 107-114 interferon gamma Homo sapiens 183-191 34937023-0 2021 Crosslinked layered surfaces of heparin and poly(L-lysine) enhance mesenchymal stromal cells behavior in the presence of soluble interferon gamma. Heparin 32-39 interferon gamma Homo sapiens 129-145 34937023-3 2021 The aim of this study is to evaluate multilayers of heparin and poly(L-lysine) (HEP/PLL) as a bioactive surface for hMSCs stimulated with soluble interferon gamma (IFN-gamma). Heparin 52-59 interferon gamma Homo sapiens 146-173 1934005-1 1991 Heparan sulfate and heparin, new targets for IFN-gamma, protect, relax the cytokine and regulate its activity. Heparin 20-27 interferon gamma Homo sapiens 45-54 34639073-2 2021 The mechanism of heparin binding to IFNgamma and IL-6 and the resulting inhibition of their activity were studied by means of extensive molecular-dynamics simulations. Heparin 17-24 interferon gamma Homo sapiens 36-44 33790886-6 2021 Alternatively, combining CFP-10-induced TNF-alpha and IP-10 with heparin-binding haemagglutinin (HBHA)-induced-IFN-gamma was more effective in testing recently BCG-vaccinated children or those suspected to be infected with non-tuberculous mycobacteria, providing a correct classification of 97% of the M. tuberculosis-infected children. Heparin 65-72 interferon gamma Homo sapiens 111-120 34270559-0 2021 Mycobacterial heparin-binding hemagglutinin (HBHA)-induced interferon-gamma release assay (IGRA) for discrimination of latent and active tuberculosis: A systematic review and meta-analysis. Heparin 14-21 interferon gamma Homo sapiens 59-75 32824699-7 2020 In human NK cells, heparin promisingly increased interferon (IFN)-gamma production in synergy with IL-12, although the mechanism remains elusive. Heparin 19-26 interferon gamma Homo sapiens 49-71 32763614-4 2020 The immunomodulatory extracellular matrix hydrogels (iECM) consist of an interpenetrating network of click functionalized-alginate and fibrillar collagen, in which interferon gamma (IFN-gamma) loaded heparin-coated beads are incorporated. Heparin 200-207 interferon gamma Homo sapiens 164-191 32763614-6 2020 Moreover, the inclusion of IFN-gamma loaded heparin-coated beads prolonged the expression of key regulatory genes upregulated upon licensing, including indoleamine 2,3-dioxygenase 1 (IDO1) and galectin-9 (GAL9). Heparin 44-51 interferon gamma Homo sapiens 27-36 31794784-0 2020 The role of heparin/heparan sulphate in the IFN-gamma-led Arena. Heparin 12-19 interferon gamma Homo sapiens 44-53 31794784-12 2020 This paper summarizes research progress on the IFN-gamma signalling pathway, heparin interference with IFN-gamma activity and the structure-activity relationship between heparin and IFN-gamma. Heparin 77-84 interferon gamma Homo sapiens 103-112 31794784-7 2020 The structural similarity provides a basis for modelling exogenous heparin dependence for interference with IFN-gamma function. Heparin 67-74 interferon gamma Homo sapiens 108-117 31794784-12 2020 This paper summarizes research progress on the IFN-gamma signalling pathway, heparin interference with IFN-gamma activity and the structure-activity relationship between heparin and IFN-gamma. Heparin 77-84 interferon gamma Homo sapiens 103-112 31794784-9 2020 Second, the principle of priority occupancy; heparin can occupy the receptor binding site on cytokines, partially preventing the IFN-gamma-IFN-gammaR interaction. Heparin 45-52 interferon gamma Homo sapiens 129-138 31794784-11 2020 To decipher the mechanism by which heparin influences IFN-gamma activity, studies of the structure-activity relationship are in progress. Heparin 35-42 interferon gamma Homo sapiens 54-63 28170190-6 2017 Delivery of IFN-gamma via heparin-microparticles within MSC aggregates induced sustained IDO expression during 1 week of culture, whereas IDO expression by IFN-gamma-pretreated MSC spheroids rapidly decreased during 2 days. Heparin 26-33 interferon gamma Homo sapiens 12-21 33405584-2 2019 In this study, multilayers of heparin and collagen (HEP/COL) were used as a bioactive surface coating to enhance human MSC (hMSC) response to soluble interferon-gamma (IFN-gamma). Heparin 30-37 interferon gamma Homo sapiens 150-166 33405584-2 2019 In this study, multilayers of heparin and collagen (HEP/COL) were used as a bioactive surface coating to enhance human MSC (hMSC) response to soluble interferon-gamma (IFN-gamma). Heparin 30-37 interferon gamma Homo sapiens 168-177 23734709-2 2013 To understand the forces that drive such interactions the binding of heparin to interferon-gamma (IFNgamma), used as a model system, was investigated. Heparin 69-76 interferon gamma Homo sapiens 80-96 23734709-2 2013 To understand the forces that drive such interactions the binding of heparin to interferon-gamma (IFNgamma), used as a model system, was investigated. Heparin 69-76 interferon gamma Homo sapiens 98-106 17536787-4 2007 In addition, direct binding of NKp44 to heparin was observed, and soluble heparin/heparan sulfate enhanced the secretion of IFNgamma by NK92 cells activated with anti-NKp44 monoclonal antibody. Heparin 74-81 interferon gamma Homo sapiens 124-132 23160925-0 2013 Heparins modulate the IFN-gamma-induced production of chemokines in human breast cancer cells. Heparin 0-8 interferon gamma Homo sapiens 22-31 23160925-8 2013 UFH dose dependently inhibited the effect of IFN-gamma on the secretion and expression of CXCL9 and CXCL10. Heparin 0-3 interferon gamma Homo sapiens 45-54 23160925-9 2013 LMWHs and heparin-related compounds differentially modulated IFN-gamma-effects-the results depended on their molecular size and charge, but were independent of their anticoagulatory properties. Heparin 10-17 interferon gamma Homo sapiens 61-70 23160925-10 2013 As a reason for these heparin effects, we could show that the IFN-gamma-induced phosphorylation of STAT1 was modulated by heparins, caused by an interaction with the cellular binding of IFN-gamma. Heparin 22-29 interferon gamma Homo sapiens 62-71 23160925-10 2013 As a reason for these heparin effects, we could show that the IFN-gamma-induced phosphorylation of STAT1 was modulated by heparins, caused by an interaction with the cellular binding of IFN-gamma. Heparin 22-29 interferon gamma Homo sapiens 186-195 23160925-10 2013 As a reason for these heparin effects, we could show that the IFN-gamma-induced phosphorylation of STAT1 was modulated by heparins, caused by an interaction with the cellular binding of IFN-gamma. Heparin 122-130 interferon gamma Homo sapiens 62-71 23160925-10 2013 As a reason for these heparin effects, we could show that the IFN-gamma-induced phosphorylation of STAT1 was modulated by heparins, caused by an interaction with the cellular binding of IFN-gamma. Heparin 122-130 interferon gamma Homo sapiens 186-195 20542267-0 2011 Heparin inhibits interferon-gamma signaling in human endometrial stromal cells by interference with the cellular binding of interferon-gamma. Heparin 0-7 interferon gamma Homo sapiens 17-33 20542267-0 2011 Heparin inhibits interferon-gamma signaling in human endometrial stromal cells by interference with the cellular binding of interferon-gamma. Heparin 0-7 interferon gamma Homo sapiens 124-140 20542267-1 2011 OBJECTIVE: To examine the impact of heparins on interferon-gamma (IFN-gamma) signaling in human endometrial stromal cells (ESCs) in vitro. Heparin 36-44 interferon gamma Homo sapiens 48-64 20542267-1 2011 OBJECTIVE: To examine the impact of heparins on interferon-gamma (IFN-gamma) signaling in human endometrial stromal cells (ESCs) in vitro. Heparin 36-44 interferon gamma Homo sapiens 66-75 20542267-9 2011 RESULT(S): Heparin and LMWHs inhibit the IFN-gamma-mediated induction of IRF-1, but not Nmi in undifferentiated and decidualized ESCs. Heparin 11-18 interferon gamma Homo sapiens 41-50 20542267-11 2011 Heparin has no effect on the IFN-gamma receptor in ESCs, but inhibits the binding of IFN-gamma to the cells. Heparin 0-7 interferon gamma Homo sapiens 85-94 20542267-12 2011 CONCLUSION(S): Unfractionated heparin, as well as LMWHs, are able to inhibit IFN-gamma signaling in human ESCs and therefore might be clinically interesting agents to modulate the actions of this proinflammatory cytokine at the implantation site. Heparin 30-37 interferon gamma Homo sapiens 77-86 16940188-1 2006 BACKGROUND: Heparin, used clinically as an anticoagulant, also has antiinflammatory properties and has been described to inhibit interferon (IFN)-gamma responses in endothelial cells. Heparin 12-19 interferon gamma Homo sapiens 129-151 17073444-10 2006 For oligosaccharides of 14 and 20 nm, two types of complexes are formed with one IFN-gamma and one or two heparin molecules. Heparin 106-113 interferon gamma Homo sapiens 81-90 16940188-2 2006 We investigated the effects of heparin on the IFN-gamma-inducible chemokines IP-10/CXCL10, I-TAC/CXCL11, and Mig/CXCL9, which play important roles in the vascular recruitment of IFN-gamma-producing Th1 cells through interactions with their cognate receptor, CXCR3. Heparin 31-38 interferon gamma Homo sapiens 46-55 16940188-6 2006 We confirmed previous reports that heparin inhibits the IFN-gamma-dependent production of CXCR3 chemokine ligands using atherosclerotic coronary arteries in organ culture. Heparin 35-42 interferon gamma Homo sapiens 56-65 16940188-9 2006 CONCLUSIONS: Besides inhibiting IFN-gamma responses, heparin has further immunomodulatory effects by competing for binding with IP-10, I-TAC, and Mig on endothelial cells. Heparin 53-60 interferon gamma Homo sapiens 32-41 16556679-3 2006 We now demonstrate that heparin abrogates apoptosis of primary first trimester villous trophoblast in response to treatment with the pro-inflammatory cytokines interferon (IFN)-gamma and tumour necrosis factor (TNF)-alpha. Heparin 24-31 interferon gamma Homo sapiens 160-182 15269982-5 2004 RESULT: Human recombinant IFN-gamma bound to heparin in a concentration dependent manner, the binding of IFN-gamma to HBC was detected at the concentration of 0.25 ng, and saturated at around 2 ng. Heparin 45-52 interferon gamma Homo sapiens 26-35 16155294-0 2005 Heparan sulfate mimicry: a synthetic glycoconjugate that recognizes the heparin binding domain of interferon-gamma inhibits the cytokine activity. Heparin 72-79 interferon gamma Homo sapiens 98-114 15269982-5 2004 RESULT: Human recombinant IFN-gamma bound to heparin in a concentration dependent manner, the binding of IFN-gamma to HBC was detected at the concentration of 0.25 ng, and saturated at around 2 ng. Heparin 45-52 interferon gamma Homo sapiens 106-115 15269982-6 2004 Free heparin, LMW heparin, CS,HA and carrageenans competed for the binding of IFN-gamma to HBC with significant different ability. Heparin 5-12 interferon gamma Homo sapiens 78-87 11801647-9 2002 Functionally, heparin-treated DCs respond to LPS or LPS plus IFN-gamma with higher IL-10 and less IL-12 production than heparin-untreated DCs. Heparin 14-21 interferon gamma Homo sapiens 61-70 15072225-0 2004 Heparin inhibits IFN-gamma-induced fractalkine/CX3CL1 expression in human endothelial cells. Heparin 0-7 interferon gamma Homo sapiens 17-26 15072225-6 2004 The IFN-gamma-induced expressions of fractalkine mRNA and protein were inhibited by heparin in a concentration-dependent manner. Heparin 84-91 interferon gamma Homo sapiens 4-13 15072225-7 2004 Heparin also inhibited adhesion of mononuclear cells (MNC) to HUVEC monolayers stimulated with IFN-gamma, but it did not inhibit the MNC adhesion to the monolayers stimulated with interleukin-1beta. Heparin 0-7 interferon gamma Homo sapiens 95-104 15072225-8 2004 Electrophoretic analysis demonstrated direct binding of heparin to IFN-gamma and heparin was found to partially block the binding of IFN-gamma to IFN-gamma receptor (IFN-gamma R). Heparin 56-63 interferon gamma Homo sapiens 67-76 15072225-8 2004 Electrophoretic analysis demonstrated direct binding of heparin to IFN-gamma and heparin was found to partially block the binding of IFN-gamma to IFN-gamma receptor (IFN-gamma R). Heparin 56-63 interferon gamma Homo sapiens 133-142 15072225-8 2004 Electrophoretic analysis demonstrated direct binding of heparin to IFN-gamma and heparin was found to partially block the binding of IFN-gamma to IFN-gamma receptor (IFN-gamma R). Heparin 56-63 interferon gamma Homo sapiens 133-142 15072225-8 2004 Electrophoretic analysis demonstrated direct binding of heparin to IFN-gamma and heparin was found to partially block the binding of IFN-gamma to IFN-gamma receptor (IFN-gamma R). Heparin 56-63 interferon gamma Homo sapiens 133-142 15072225-8 2004 Electrophoretic analysis demonstrated direct binding of heparin to IFN-gamma and heparin was found to partially block the binding of IFN-gamma to IFN-gamma receptor (IFN-gamma R). Heparin 81-88 interferon gamma Homo sapiens 133-142 15072225-8 2004 Electrophoretic analysis demonstrated direct binding of heparin to IFN-gamma and heparin was found to partially block the binding of IFN-gamma to IFN-gamma receptor (IFN-gamma R). Heparin 81-88 interferon gamma Homo sapiens 133-142 15072225-8 2004 Electrophoretic analysis demonstrated direct binding of heparin to IFN-gamma and heparin was found to partially block the binding of IFN-gamma to IFN-gamma receptor (IFN-gamma R). Heparin 81-88 interferon gamma Homo sapiens 133-142 11801647-9 2002 Functionally, heparin-treated DCs respond to LPS or LPS plus IFN-gamma with higher IL-10 and less IL-12 production than heparin-untreated DCs. Heparin 120-127 interferon gamma Homo sapiens 61-70