PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27899064-5	2017	We also found that heparin inhibited both GDF5 binding to cell surface HS and GDF5-induced induction of Smad 1/5/8 signaling.	Heparin	19-26	SMAD family member 1	Homo sapiens	104-112	
26955355-2	2015	Heparins seem to act by interfering with BMP6 signaling pathways that control the expression of liver hepcidin, causing the suppression of SMAD1/5/8 phosphorylation.	Heparin	0-8	SMAD family member 1	Homo sapiens	139-146	
26474791-9	2015	Importantly, the BMP-2 released from all the heparin particle types was found by the SMAD 1/5/8 phosphorylation assay to be biologically active.	Heparin	45-52	SMAD family member 1	Homo sapiens	85-93	
18449905-5	2008	Heparin was found to suppress the mRNA expressions of osterix, Runx2, ALP and osteocalcin, as well as phosphorylation of Smad1/5/8 and p38 MAPK.	Heparin	0-7	SMAD family member 1	Homo sapiens	121-130	
16754660-6	2006	Heparin enhanced BMP-2-induced gene expression and Smad1/5/8 phosphorylation at 24 h and thereafter, although not within 12 h. Heparitinase treatment did not affect the response of cells to BMP-2.	Heparin	0-7	SMAD family member 1	Homo sapiens	51-58