PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25378396-3 2014 Secreted Klotho (sKL) up-regulates the TRPV5 calcium channel from the cell exterior by removing sialic acids from N-glycan of the channel and inhibiting its endocytosis. Sialic Acids 96-108 klotho Homo sapiens 9-15 18606998-6 2008 Here, we report that the extracellular domain of Klotho activates plasma-membrane resident TRPV5 through removing terminal sialic acids from their glycan chains. Sialic Acids 123-135 klotho Homo sapiens 49-55 22396165-4 2012 Removal of terminal sialic acids from N-glycan chains of the epithelial Ca(2+) channel TRPV5 and the renal K(+) channel ROMK by secreted Klotho exposes the underlying disaccharide galactose-N-acetylglucosamine, a ligand for galectin-1. Sialic Acids 20-32 klotho Homo sapiens 137-143