PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33892139-6 2021 High molecular weight (HMW) poly I:C (1-6kb, 12 mg/kg) produced more robust sickness behavior and more robust IL-6, IFN-I and TNF-alpha responses than poly I:C of <500 bases (low MW) preparations. Poly I-C 28-36 interleukin 6 Mus musculus 110-114 34028652-7 2021 Polyinosinic: polycytidylic acid (poly [I:C])-stimulated macrophage cells and 10-7 M 1,25 OH-vitamin D3 significantly decreased gene expression of ICAM1, TLR3, IL6, IL8, and TNFalpha (P < 0.0001). Poly I-C 34-44 interleukin 6 Mus musculus 160-163 33892139-8 2021 In aged animals, poly I:C induced exaggerated IL-6, IL-1beta and IFN-I in the plasma and similar exaggerated brain cytokine responses. Poly I-C 17-25 interleukin 6 Mus musculus 46-50 31262388-8 2019 In BALB/c mice, Rv0674 adjuvant by DDA/Poly I:C could also induce a high level of IFN-gamma, interleukin-2 and interleukin-6 as well as a high IgG titer in both high- and low-dose groups indicating that Rv0674 is essential in humoral and cellular immunity. Poly I-C 39-47 interleukin 6 Mus musculus 111-124 33310189-6 2021 In the MIA model of gestational polyinosinic-polycytidylic acid (poly(I:C)) exposure, increased serum levels of IL-6 were observed in both wild-type (WT) and Nox1-deficient mice (Nox1KO). Poly I-C 32-63 interleukin 6 Mus musculus 112-116 33310189-6 2021 In the MIA model of gestational polyinosinic-polycytidylic acid (poly(I:C)) exposure, increased serum levels of IL-6 were observed in both wild-type (WT) and Nox1-deficient mice (Nox1KO). Poly I-C 65-74 interleukin 6 Mus musculus 112-116 32390869-5 2020 In response to poly(I:C) stimulation, PKCdelta deficient macrophages displayed an increased production of IL-1beta, IL-6, TNF-alpha, and IL-33, which were associated with an enhanced NF-kappaB activation. Poly I-C 15-24 interleukin 6 Mus musculus 116-120 32322251-5 2020 Orally administered MPL16 prior intraperitoneal injection of poly(I:C) significantly reduced the levels of the proinflammatory mediators tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6), and IL-15 in the intestinal mucosa. Poly I-C 61-70 interleukin 6 Mus musculus 193-197 31820024-10 2020 Concentrations of IL-6, RANTES, and MIP-2 induced by HDM and poly(I:C) were significantly suppressed by EM900 through the suppression of NF-kappaB and p38 phosphorylation in macrophages. Poly I-C 61-70 interleukin 6 Mus musculus 18-22 33442686-6 2021 High molecular weight (HMW) poly I:C (1 to 6 kb, 12 mg/kg) produced more robust sickness behavior and more robust IL-6, IFN-I and TNF alpha responses than poly I:C of less than 500 bases (low MW) preparations. Poly I-C 28-36 interleukin 6 Mus musculus 114-118 33442686-8 2021 In aged animals, poly I:C induced exaggerated IL-6, IL-1beta and IFN-I in the plasma and similar exaggerated brain cytokine responses. Poly I-C 17-25 interleukin 6 Mus musculus 46-50 32328062-7 2020 The oral administration of L. plantarum WT to mice prior the intraperitoneal injection of poly(I:C) significantly increased IFN-beta and IL-10 and reduced intraepithelial lymphocytes (CD3+NK1.1+CD8alphaalpha+) and pro-inflammatory mediators (TNF-alpha, IL-6, and IL-15) in the intestinal mucosa. Poly I-C 90-99 interleukin 6 Mus musculus 253-257 31057355-6 2019 Poly(I:C) increased the circulating levels of cytokines (TNF-alpha, MCP-1, IL-6, IL-10, IFN-alpha, IFN-gamma), an effect amplified by IF. Poly I-C 0-8 interleukin 6 Mus musculus 75-79 28746799-9 2017 Finally, we confirmed that in vivo injection of an anti-PD-L1 antibody or a Toll-like receptor 3 ligand, polyinosinic-polycytidylic acid, effectively inhibited tumorigenesis under the IL-6-deficient condition. Poly I-C 105-136 interleukin 6 Mus musculus 184-188 28222448-12 2017 RESULTS: PolyI:C exposure (4h) significantly elevated maternal plasma IL-6 (P<0.001) and increased [3H]digoxin accumulation in the fetal brain (P<0.05). Poly I-C 9-16 interleukin 6 Mus musculus 70-74 28747347-4 2017 TRIM8 deficiency leads to increased polyinosinic-polycytidylic acid- and LPS-triggered induction of downstream anti-microbial genes including TNF, Il6, Rantes, and Ifnb, evaluated serum cytokine levels, and increased susceptibility of mice to polyinosinic-polycytidylic acid- and LPS-induced inflammatory death as well as Salmonella typhimurium infection-induced loss of body weight and septic shock. Poly I-C 36-67 interleukin 6 Mus musculus 147-150 28844021-6 2017 Cells transfected with TRIF, TRAF6, RIP1 or TAK1 all decreased production of poly(I:C)-induced IL-1alpha, IL-1beta, IL-6, GRO-alpha, IL-8, MCP-1, ICAM-1 and MMP-9 expression. Poly I-C 77-86 interleukin 6 Mus musculus 116-120 25158758-12 2014 Similarly, recombinant galectin-9 enhanced poly(I:C)-induced microglial TNF and IL-6 production. Poly I-C 43-52 interleukin 6 Mus musculus 80-84 24179040-4 2014 We show that pre-treatment of macrophages with Berenil dramatically suppressed IL-6, IL-12 and TNF-alpha production following LPS, CpG and Poly I:C stimulation without altering the expression of TLRs. Poly I-C 139-147 interleukin 6 Mus musculus 79-83 23954861-6 2014 Moreover, after poly(I : C) injection, Rip3(-/-) mice displayed decreased levels of pro-inflammatory cytokines (such as TNF-alpha and IL-6) in the retina, and attenuated intravitreal release of high-mobility group box-1 (HMGB1), a major damage-associated molecular pattern (DAMP). Poly I-C 16-26 interleukin 6 Mus musculus 134-138 24384468-9 2014 Higher levels of IL-2, IL-5 and IL-6 in plasma and an upregulation of the metabotropic receptor 5 (mGluR5) in foetal brains of 10-day-old offspring prenatally exposed to poly I:C was also observed. Poly I-C 170-178 interleukin 6 Mus musculus 32-36 23954861-7 2014 In vitro, poly(I : C)-induced necrosis were inhibited in Rip3-deficient RPE cells, which in turn suppressed HMGB1 release and dampened TNF-alpha and IL-6 induction evoked by necrotic supernatants. Poly I-C 10-21 interleukin 6 Mus musculus 149-153 21315785-11 2011 In female mice, however, corticosterone does appear to mediate the persistent effects of acute ethanol administration on poly I:C- induced IL-6 levels. Poly I-C 121-129 interleukin 6 Mus musculus 139-143 23738811-7 2013 Our results thus indicate that the systemic neutralization of IL-6 significantly reduces CS/poly(I:C)-induced pulmonary inflammation, which may be a relevant approach to the treatment of episodes of acute pulmonary inflammation associated with COPD. Poly I-C 92-101 interleukin 6 Mus musculus 62-66 23637159-6 2013 Interleukin-6 (IL-6) is a critical cytokine for mediating the behavioral and transcriptional effects of polyI:C. Poly I-C 104-111 interleukin 6 Mus musculus 0-13 23637159-6 2013 Interleukin-6 (IL-6) is a critical cytokine for mediating the behavioral and transcriptional effects of polyI:C. Poly I-C 104-111 interleukin 6 Mus musculus 15-19 23637159-7 2013 We found a more pronounced increase of IL-6 in response to polyI:C in fetal brain in Disc1-L100P(+/-) mice compared with WT or Disc1-Q31L(+/-) mice. Poly I-C 59-66 interleukin 6 Mus musculus 39-43 23637159-8 2013 Coadministration of an anti-IL-6 antibody with polyI:C reversed schizophrenia-related behavioral phenotypes in Disc1-L100P(+/-) mice. Poly I-C 47-54 interleukin 6 Mus musculus 28-32 23051007-5 2013 Both poly I:C and LPS stimulation in porcine islets induced expression of chemokines (RANTES, MCP-1, IP-10, and IL-8), cytokines (IL-6 and type I interferons), and adhesion molecules (VCAM-1 and ICAM-1). Poly I-C 5-13 interleukin 6 Mus musculus 130-134 22983393-12 2012 Moreover, Poly I:C significantly suppressed the pro-inflammatory cytokines TNFalpha and IL-6 production. Poly I-C 10-18 interleukin 6 Mus musculus 88-92 23907982-10 2013 PIC-induced behavioral deficits were abolished by IL-6 antibodies and were mimicked by recombinant IL-6; IL-1beta was not involved. Poly I-C 0-3 interleukin 6 Mus musculus 50-54 23907982-10 2013 PIC-induced behavioral deficits were abolished by IL-6 antibodies and were mimicked by recombinant IL-6; IL-1beta was not involved. Poly I-C 0-3 interleukin 6 Mus musculus 99-103 23023014-9 2013 Infiltrated macrophage numbers and the expression of tumor necrosis factor-alpha, monocyte chemoattractant protein-1 and IL-6 on these cells were decreased after poly I:C treatment. Poly I-C 162-170 interleukin 6 Mus musculus 121-125 23028093-3 2013 Concurrently, nicotine treatment attenuated the release of IL-6 and TNF-alpha from poly(I:C)-stimulated macrophages. Poly I-C 83-92 interleukin 6 Mus musculus 59-63 23028093-4 2013 However, when poly(I:C)-stimulated macrophages were challenged with nicotine plus alpha-bungarotoxin (alpha-BTX), secretion of IL-6 and TNF-alpha was found to be in a level seen with poly(I:C) stimulation only, indicating that alpha7-nAChR, a highly Ca(2+) permeable ion channel sensitive to blockade by alpha-BTX, is involved in this process. Poly I-C 14-23 interleukin 6 Mus musculus 127-131 23028093-4 2013 However, when poly(I:C)-stimulated macrophages were challenged with nicotine plus alpha-bungarotoxin (alpha-BTX), secretion of IL-6 and TNF-alpha was found to be in a level seen with poly(I:C) stimulation only, indicating that alpha7-nAChR, a highly Ca(2+) permeable ion channel sensitive to blockade by alpha-BTX, is involved in this process. Poly I-C 14-22 interleukin 6 Mus musculus 127-131 21206981-5 2011 When stimulated with poly I:C (and also LPS) JAWSII cells produced large amounts of IL-6, TNF-alpha and MCP-1. Poly I-C 21-29 interleukin 6 Mus musculus 84-88 21111765-8 2011 Importantly, whereas injection of soluble poly(I:C) led to rapid production of the pro-inflammatory cytokines tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 in serum, administration of poly(I:C) in complex with the cationic DDA/TDB liposomes prevented this non-specific systemic pro-inflammatory response. Poly I-C 42-50 interleukin 6 Mus musculus 148-166 21111765-8 2011 Importantly, whereas injection of soluble poly(I:C) led to rapid production of the pro-inflammatory cytokines tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 in serum, administration of poly(I:C) in complex with the cationic DDA/TDB liposomes prevented this non-specific systemic pro-inflammatory response. Poly I-C 195-203 interleukin 6 Mus musculus 148-166 16517751-6 2006 Furthermore, wild-type microglia dose dependently secreted TNF-alpha and IL-6 after poly(I:C) challenge, whereas TLR3(-/-) microglia produced diminished cytokines. Poly I-C 84-93 interleukin 6 Mus musculus 73-77 20980632-4 2010 In vivo administration of CpG, polyinosinic-polycytidylic acid, and Pam(3)CSK(4) in combination with Ag resulted in the increased expression of costimulatory molecules and MHC class II by DCs, increased serum levels of the inflammatory cytokines IL-6 and RANTES, and increased cognate CD4 T cell responses in young and aged mice. Poly I-C 31-62 interleukin 6 Mus musculus 246-250 20218969-3 2010 Results showed that exogenously added apoE suppressed the LPS and poly(I-C) induction of IL (interleukin)-6, IL-1beta and TNF-alpha (tumour necrosis factor-alpha) secretion by RAW 264.7 cells. Poly I-C 66-75 interleukin 6 Mus musculus 89-107 19036857-3 2009 Whereas extracellular poly I:C (naked poly I:C) mainly induced the expression of regulated on activation normal T-cell expressed and secreted (RANTES), interleukin-8 (IL-8), and tumor necrosis factor alpha (TNF-alpha), intracellular delivery of poly I:C (complexed poly I:C) chiefly induced expression of IFN-beta and IL-6. Poly I-C 22-30 interleukin 6 Mus musculus 318-322 19036857-3 2009 Whereas extracellular poly I:C (naked poly I:C) mainly induced the expression of regulated on activation normal T-cell expressed and secreted (RANTES), interleukin-8 (IL-8), and tumor necrosis factor alpha (TNF-alpha), intracellular delivery of poly I:C (complexed poly I:C) chiefly induced expression of IFN-beta and IL-6. Poly I-C 38-46 interleukin 6 Mus musculus 318-322 19036857-3 2009 Whereas extracellular poly I:C (naked poly I:C) mainly induced the expression of regulated on activation normal T-cell expressed and secreted (RANTES), interleukin-8 (IL-8), and tumor necrosis factor alpha (TNF-alpha), intracellular delivery of poly I:C (complexed poly I:C) chiefly induced expression of IFN-beta and IL-6. Poly I-C 38-46 interleukin 6 Mus musculus 318-322 19036857-3 2009 Whereas extracellular poly I:C (naked poly I:C) mainly induced the expression of regulated on activation normal T-cell expressed and secreted (RANTES), interleukin-8 (IL-8), and tumor necrosis factor alpha (TNF-alpha), intracellular delivery of poly I:C (complexed poly I:C) chiefly induced expression of IFN-beta and IL-6. Poly I-C 38-46 interleukin 6 Mus musculus 318-322 17267173-3 2007 In naive mice, poly I:C (2mg/kg) modestly increased sickness behaviors, plasma IL-6, TNF-alpha and IL-10 levels, but did not affect IL-1, IL-4, or IFN-gamma. Poly I-C 15-23 interleukin 6 Mus musculus 79-83 19717524-6 2009 Mal deficiency boosted IL-6 induction by the TLR3 ligand polyinosinic-polycytidylic acid. Poly I-C 57-88 interleukin 6 Mus musculus 23-27 34903784-6 2021 We find that, 4 h after the administration, both poly I:C and resiquimod elevated the levels of IL-6, TNFalpha, and chemokines including CCL2 and CCL5, in maternal plasma. Poly I-C 49-57 interleukin 6 Mus musculus 96-100 1451333-6 1992 Interestingly, the addition of combinations of IL-1 and IL-6 increased the proliferation of T cells in response to KLH presented by either saline- or poly(I:C)-treated M phi. Poly I-C 150-159 interleukin 6 Mus musculus 56-60 15313929-7 2004 In vivo stimulation of mice with pIC and CpG-ODN demonstrated synergy for serum IL-6 and IL-12p40 levels that correlated with an enhanced antitumor effect against established B16-F10 experimental pulmonary metastases. Poly I-C 33-36 interleukin 6 Mus musculus 80-84 34665110-8 2021 Further, polyI:C stimulation of bone marrow-derived macrophages (BMDMs) induced TNF-alpha, IFN-beta, IL-6 and Nos-2, but responses were not different in BMDMs generated from WT or vip-/- mice. Poly I-C 9-16 interleukin 6 Mus musculus 101-105 34832320-7 2021 Similarly, when RAW 264.7 macrophages were incubated with other agonists of Toll-like receptor (TLR) signaling e.g., FSL1, Polyinosinic-polycytidylic acid High Molecular Weight (Poly (1:C) HMW), Pam3CSK4, and imiquimod, ADL reduced the IL6 expression. Poly I-C 123-154 interleukin 6 Mus musculus 236-239 34497658-10 2021 LBO could also effectively downregulate the expression of interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and interferon-beta and the activation of P65 and IRF3 in Poly I:C-treated cells. Poly I-C 168-176 interleukin 6 Mus musculus 103-107