PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31111539-6	2019	Poly (I:C) significantly upregulated proinflammatory cytokines, including tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-6, IL-1beta and type I interferon (IFN-alpha/beta), and the innate immune responses were significantly reduced by blocking TLR3 signaling.	Poly I-C	0-9	interleukin 1 beta	Homo sapiens	135-143	
9374789-5	1997	Poly(I-C)-induced monocytic cell adhesion to primary EC was concentration-dependently inhibited by 40-74% by the nitric oxide synthase (NOS) inhibitor NG-methyl-L-arginine (L-NMA), as well as three other NOS inhibitors, without significantly affecting interleukin-1 beta-induced adhesion.	Poly I-C	0-8	interleukin 1 beta	Homo sapiens	252-270	
33583094-7	2021	Interestingly, when keratinocytes were stimulated with a TLR3 agonist, RGRN-305 also demonstrated potent immunomodulatory effects, significantly inhibiting poly(I:C)-induced expression of the proinflammatory genes TNFalpha, IL1B, IL6, and IL23A.	Poly I-C	156-165	interleukin 1 beta	Homo sapiens	224-228	
31333667-4	2019	PolyI:C increased the expression of interferon-beta (IFN-beta), interleukin-6 (IL-6), interleukin-8 (IL-8), monocyte chemoattractant protein (MCP-1), and interleukin-1beta (IL-1beta) in HCT116 cells, and these up-regulations were significantly altered when cells were pre-stimulated with LAB isolated from Korean fermented foods.	Poly I-C	0-7	interleukin 1 beta	Homo sapiens	154-171	
31534438-6	2019	We found that poly I:C induced increased expression of the proinflammatory cytokines IL1beta, IL6, CXCL8, and TNF and IFN-beta1 in AECs from both control subjects and COPD patients.	Poly I-C	14-22	interleukin 1 beta	Homo sapiens	85-92	
28266737-6	2017	We transfected polyinosinic:polycytidylic acid (poly I:C), a synthetic viral dsRNA analogue, into cultured primary human keratinocytes at the aid of Lipofectamine 2000, and found that transfected poly I:C activated caspase-1 and induced caspase-1-dependent release of IL-1beta and IL-18, which were suppressed on transfection with NLRP3 siRNA.	Poly I-C	48-56	interleukin 1 beta	Homo sapiens	268-276	
28266737-6	2017	We transfected polyinosinic:polycytidylic acid (poly I:C), a synthetic viral dsRNA analogue, into cultured primary human keratinocytes at the aid of Lipofectamine 2000, and found that transfected poly I:C activated caspase-1 and induced caspase-1-dependent release of IL-1beta and IL-18, which were suppressed on transfection with NLRP3 siRNA.	Poly I-C	196-204	interleukin 1 beta	Homo sapiens	268-276	
27210890-7	2016	KEY FINDINGS: RA significantly inhibited poly(I:C)-induced expression of inflammatory cytokines including IL-1beta, IL-6, IL-8, CCL20, and TNF-alpha, and downregulated NF-kappaB signaling pathway in human keratinocytes.	Poly I-C	41-50	interleukin 1 beta	Homo sapiens	106-114	
28394395-4	2017	The results showed that the induction of the expression of IL1B, IL6 and CXCLi2 by poly I:C, LPS, and CpG-ODN were suppressed by Bay11-7085, but not by tanshinone IIA.	Poly I-C	83-91	interleukin 1 beta	Homo sapiens	59-63	
27210890-8	2016	In addition, RA significantly inhibited poly(I:C)-induced inflammasome activation, in terms of secretion of active form of IL-1beta and caspase-1.	Poly I-C	40-49	interleukin 1 beta	Homo sapiens	123-131	
25059418-7	2015	Treatment with poly(I:C) specifically up-regulated surface expression of co-stimulatory molecules and increased release of IL-12p70 in MoLC and co-stimulation with TNF-alpha and IL-1beta further elevated Th1 and Th17 cytokine production.	Poly I-C	15-23	interleukin 1 beta	Homo sapiens	178-186	
23845419-10	2013	The release of IL-1beta was due to polyI:C induced cell death that occurred through a caspase-4 dependent manner.	Poly I-C	35-42	interleukin 1 beta	Homo sapiens	15-23	
25271853-8	2014	Addition of IL-6 to the same cells after stimulation with poly(I-C), CpG, Pam2CSK4, and MDP induced a significant increase in IL-1beta and CXCL8, but not TNF-alpha production compared with TLR ligands alone.	Poly I-C	58-67	interleukin 1 beta	Homo sapiens	126-134	
25315747-6	2014	Human platelets responded to poly I:C by increasing [Ca(2+)]i, the percentages of cells expressing TLR4 and CD62P, and by releasing CXCL4 and IL-1beta in comparison to unstimulated platelets.	Poly I-C	29-37	interleukin 1 beta	Homo sapiens	142-150	
23850670-5	2013	Poly I:C synergistically enhanced CCL20 expression from IL-1beta-stimulated HGFs.	Poly I-C	0-8	interleukin 1 beta	Homo sapiens	56-64	
22915814-5	2012	Poly(I C) pretreatment upregulated beta interferon (IFN-beta), IFN-gamma, IL-1beta, and tumor necrosis factor (TNF) gene expression in the lungs.	Poly I-C	0-8	interleukin 1 beta	Homo sapiens	74-82	
23631691-9	2013	Furthermore, TNF-alpha and IL-1beta secretion in PAMs from group LP was statistically greater than those from the control group after stimulation with either poly(I:C) or CL097.	Poly I-C	158-167	interleukin 1 beta	Homo sapiens	27-35	
21964048-7	2011	Further studies indicated that IL-1beta was involved in TLR3-induced cell proliferation inhibition, as IL-1beta inhibited cell proliferation in a dose-dependent manner, and the IL-1beta receptor type I (IL-1R1)-neutralizing antibody ameliorated Poly I:C-induced cell proliferation inhibition.	Poly I-C	245-253	interleukin 1 beta	Homo sapiens	31-39	
21349431-5	2011	In vivo, poly(I:C)-induced type I IFN diminished IL-1beta production in response to alum and Candida albicans, thus increasing susceptibility to this fungal pathogen.	Poly I-C	9-18	interleukin 1 beta	Homo sapiens	49-57	
19740321-7	2009	Additionally, poly(I:C) affected IL-1beta production and the migratory behaviour of Detroit-562.	Poly I-C	14-22	interleukin 1 beta	Homo sapiens	33-41	
20728939-5	2010	Furthermore, we provide evidence that Poly I:C induced expression of IL-1beta, TNFalpha, IL-12p70 and IFN-beta was blocked by JNK inhibitor SP600125.	Poly I-C	38-46	interleukin 1 beta	Homo sapiens	69-77	
20435591-7	2010	CONCLUSIONS: Poly(I:C) induces the expression of MMP-1 and MMP-3 in human corneal fibroblasts in a manner dependent on activation of the transcription factor NF-kappaB and on IL-1beta secretion.	Poly I-C	13-21	interleukin 1 beta	Homo sapiens	175-183	
19740321-9	2009	Poly(I:C) induced a small increase in IL-1beta, IL-6 and IL-8 production in HNECs, while Pam(3)CSK(4) increased viability.	Poly I-C	0-8	interleukin 1 beta	Homo sapiens	38-46	
18725521-4	2008	In this study, we show that polyinosinic:polycytidylic acid (poly[I:C]) and lipopolysaccharide stimulation of macrophages induces pro-IL-1beta processing via a Toll/IL-1R domain-containing adaptor-inducing interferon-beta-dependent signaling pathway that is initiated by TLR3 and TLR4, respectively.	Poly I-C	61-69	interleukin 1 beta	Homo sapiens	130-142	
18725521-6	2008	Surprisingly, poly(I:C)- and LPS-induced pro-IL-1beta processing still occurred in caspase-1-deficient cells.	Poly I-C	14-23	interleukin 1 beta	Homo sapiens	41-53	
17920124-6	2008	The grouper IL-1beta was constitutively expressed in almost all tissues examined, and was augmented in PBL after the addition of LPS or Poly I:C in vitro.	Poly I-C	136-144	interleukin 1 beta	Homo sapiens	12-20	
17008311-6	2006	Finally, cryopyrin was required for IL-1beta production in response to poly(I:C) in vivo.	Poly I-C	71-79	interleukin 1 beta	Homo sapiens	36-44	
17063122-6	2006	After activation with polyinosinic-polycytidylic acid, BDCs expressed higher levels of major histocompatibility complex class I, CD40, CD80, and CD83, and secreted higher levels of tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, and IL-8 compared with MoDCs.	Poly I-C	22-53	interleukin 1 beta	Homo sapiens	210-232	
18383392-7	2008	Constitutive expression of both miR-155 and miR-146a was higher in RASFs than in those from patients with osteoarthritis (OA), and expression of miR-155 could be further induced by TNFalpha, interleukin-1beta, lipopolysaccharide, poly(I-C), and bacterial lipoprotein.	Poly I-C	230-238	interleukin 1 beta	Homo sapiens	191-208