PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28790362-4 2017 The TLR3 agonist poly (I:C) activated TLR3 pathway and inhibited tumor cells proliferation through caspase-dependent apoptosis. Poly I-C 17-27 toll like receptor 3 Gallus gallus 4-8 30421962-2 2019 The purpose of the present study was to determine if intracerebroventricular (ICV) and intraperitoneal (IP) injection of polyinosinic-polycytidylic acid (poly I:C), a viral mimetic that binds to toll-like receptor-3 (TLR3), affects food intake, voluntary activity, cloacal temperature, plasma corticosterone (CORT) and glucose concentrations, and crop emptying rate in chicks (Gallus gallus). Poly I-C 121-152 toll like receptor 3 Gallus gallus 195-215 30421962-2 2019 The purpose of the present study was to determine if intracerebroventricular (ICV) and intraperitoneal (IP) injection of polyinosinic-polycytidylic acid (poly I:C), a viral mimetic that binds to toll-like receptor-3 (TLR3), affects food intake, voluntary activity, cloacal temperature, plasma corticosterone (CORT) and glucose concentrations, and crop emptying rate in chicks (Gallus gallus). Poly I-C 121-152 toll like receptor 3 Gallus gallus 217-221 28790362-4 2017 The TLR3 agonist poly (I:C) activated TLR3 pathway and inhibited tumor cells proliferation through caspase-dependent apoptosis. Poly I-C 17-27 toll like receptor 3 Gallus gallus 38-42 23876795-2 2013 Previously, we have shown in chicken monocytes that the combination of CpG, the ligand for TLR21 (the chicken equivalent of TLR9), and poly I:C, the ligand for TLR3, results in a synergistic immune response. Poly I-C 135-143 toll like receptor 3 Gallus gallus 160-164 28149670-9 2016 Injection with polyinosinic: polycytidylic acid (poly I:C), a synthetic analogue of double stranded viral RNA that binds Toll-Like Receptor-3 (TLR3), also regulated gene expressions of CCKAR and proinflammatory cytokines, in the different breeds. Poly I-C 15-47 toll like receptor 3 Gallus gallus 121-141 28149670-9 2016 Injection with polyinosinic: polycytidylic acid (poly I:C), a synthetic analogue of double stranded viral RNA that binds Toll-Like Receptor-3 (TLR3), also regulated gene expressions of CCKAR and proinflammatory cytokines, in the different breeds. Poly I-C 15-47 toll like receptor 3 Gallus gallus 143-147 22531557-10 2012 The results suggested that all of the TLR ligand treatments induced a significant reduction in virus shedding, with the TLR3 ligand poly I:C conferring the greatest AIV immunity compared to control birds, followed by CpG ODN and LPS. Poly I-C 132-140 toll like receptor 3 Gallus gallus 120-124 23116495-2 2012 To date, at least 10 different TLRs have been identified in chickens including TLR2, which binds lipopeptides and other similar ligands such as Pam3CSK4, TLR3, which binds double stranded RNA as well as synthetic molecules such as poly I:C, TLR4, which binds lipopolysaccharide (LPS), and TLR21, which binds CpG DNA motifs. Poly I-C 231-239 toll like receptor 3 Gallus gallus 154-158 17316136-4 2007 We found that polyI:C, LPS, R848, S-28463, and ODN2006, which are specifically recognized by TLR3, TLR4, TLR7/8, and TLR9 in mammals, induced substantial amounts of type I interferon (IFN) and interleukin-6 (IL-6) in freshly prepared chicken splenocytes. Poly I-C 14-21 toll like receptor 3 Gallus gallus 93-97 22120532-2 2012 Chicken TLR3 and TLR21 (avian equivalent to mammalian TLR9) recognize poly I:C (double-stranded RNA) and CpG-ODN (a CpG-motif containing oligodeoxydinucleotide), respectively. Poly I-C 70-78 toll like receptor 3 Gallus gallus 8-12 21929369-4 2012 The TLR7 ligand poly-C inhibited low-path influenza A growth in the chicken macrophage cell line HD-11 more effectively than poly(I:C), which acts via TLR3. Poly I-C 125-133 toll like receptor 3 Gallus gallus 151-155 34098343-0 2021 Poly (I: C) inhibits reticuloendothelial virus replication in chicken macrophage-like cells through the activation of toll-like receptor-3 signaling. Poly I-C 0-11 toll like receptor 3 Gallus gallus 118-138 34098343-8 2021 The above results suggested that Poly (I: C) treatment switches HD11 into M1-like polarization to secret more interferon-beta and activate TLR-3 signaling, which contributes to block REV replication. Poly I-C 33-44 toll like receptor 3 Gallus gallus 139-144 32568266-1 2020 Polyinosinic:polycytidylic acid (poly[I:C]) can stimulate Toll-like receptor 3 (TLR3) signaling pathways. Poly I-C 33-42 toll like receptor 3 Gallus gallus 80-84 32124477-4 2020 The cells were activated via toll-like receptor-3 (TLR3) by polyinosinic-polycytidylic acid sodium salt (poly I:C), mimicking viral infections. Poly I-C 105-113 toll like receptor 3 Gallus gallus 29-49 32124477-4 2020 The cells were activated via toll-like receptor-3 (TLR3) by polyinosinic-polycytidylic acid sodium salt (poly I:C), mimicking viral infections. Poly I-C 105-113 toll like receptor 3 Gallus gallus 51-55 32568266-1 2020 Polyinosinic:polycytidylic acid (poly[I:C]) can stimulate Toll-like receptor 3 (TLR3) signaling pathways. Poly I-C 33-42 toll like receptor 3 Gallus gallus 58-78 32568266-4 2020 The expressions of TLR3, TLR4, TLR7, TLR15, TLR21, IL1B, and IL10 were increased in dose- and time-dependent manners by poly(I:C) treatment. Poly I-C 120-129 toll like receptor 3 Gallus gallus 19-23 31480179-5 2019 In addition, the time- and dose-dependent expression of chLECT2 was examined in DF-1 cells which were stimulated with polyinosinic:polycytidylic acid (poly (I:C)), a TLR3 ligand. Poly I-C 118-149 toll like receptor 3 Gallus gallus 166-170