PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34643794-14	2022	In addition, bevacizumab reduced the secretion of IL-8 and TNFalpha after Poly I:C stimulation at selected time points.	Poly I-C	74-82	C-X-C motif chemokine ligand 8	Homo sapiens	50-54	
34950134-8	2021	Imiquimod also reduced poly(I:C)-induced pro-inflammatory cytokines including IL-1beta, IL-6, IL-8, and IL-33.	Poly I-C	23-32	C-X-C motif chemokine ligand 8	Homo sapiens	94-98	
34983106-5	2022	In vitro, polyinosinic:polycytidylic acid (Poly I-C) treatment markedly enhanced the production of SAA1 from AECs, which was further augmented by neutrophils; SAA1 could induce the production of interleukin (IL)-6, IL-8, and S100 calcium-binding protein A9 from AECs.	Poly I-C	43-51	C-X-C motif chemokine ligand 8	Homo sapiens	215-219	
33830449-4	2021	The purified compounds, strictinin and casuarictin, inhibited the IL-8 mRNA expression and IL-8 release induced in NHEKs by poly(I:C).	Poly I-C	124-133	C-X-C motif chemokine ligand 8	Homo sapiens	66-70	
33830449-0	2021	Ellagitannins from Rosa roxburghii suppress poly(I:C)-induced IL-8 production in human keratinocytes.	Poly I-C	44-53	C-X-C motif chemokine ligand 8	Homo sapiens	62-66	
33830449-4	2021	The purified compounds, strictinin and casuarictin, inhibited the IL-8 mRNA expression and IL-8 release induced in NHEKs by poly(I:C).	Poly I-C	124-133	C-X-C motif chemokine ligand 8	Homo sapiens	91-95	
31629806-3	2020	Modulation of basal level and poly(I:C)-induced IL-8 secretion varied between bacterial species, and between heat treated and non-heat treated bacterial cells.	Poly I-C	30-39	C-X-C motif chemokine ligand 8	Homo sapiens	48-52	
34001091-8	2021	Time course studies showed that ORMDL3-deficient A549 and NHBE cells had an attenuated IL-6 and IL-8 response to poly I:C stimulation.	Poly I-C	113-121	C-X-C motif chemokine ligand 8	Homo sapiens	96-100	
33174050-5	2020	ELISA showed that SFN was associated with a time- and dose-dependent reduction in poly(I:C)-stimulated production of interleukin (IL)-8, chemoattractant protein-1, IL-6, MMP-1 and MMP-3 by HCFs.	Poly I-C	82-91	C-X-C motif chemokine ligand 8	Homo sapiens	117-135	
32898511-9	2020	LPS, Poly I:C and TNFalpha significantly induce the secretion of IL-6 and IL-8 at all tested time points.	Poly I-C	5-13	C-X-C motif chemokine ligand 8	Homo sapiens	74-78	
34030480-9	2021	Moreover, Poly(I:C)-HMW/LyoVec and Poly(I:C)-HMW were the only ligands that significantly increased IL-8 secretion.	Poly I-C	10-19	C-X-C motif chemokine ligand 8	Homo sapiens	100-104	
34030480-10	2021	Interestingly, HBV infection reduced IL-8 secretion induced by Poly(I:C)-HMW and to a lesser extent Poly(I:C)-HMW/LyoVec.	Poly I-C	63-72	C-X-C motif chemokine ligand 8	Homo sapiens	37-41	
33911791-10	2020	Poly(I:C) increased the expression of psoriasis-related cytokines including tumor necrosis factor-alpha, interleukin-8, and CCL20, and KDM2A inhibitor daminozide enhanced the poly(I:C)-induced cytokine expression.	Poly I-C	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	105-118	
33144864-12	2020	Namely, similar to BM-MSCs, SV-MSCs secreted increased amount of IL-6 and IL-8 after 12- or 24-hour treatment with LPS, PolyI:C, TNFalpha, or IL-1beta, compared to untreated controls.	Poly I-C	120-127	C-X-C motif chemokine ligand 8	Homo sapiens	74-78	
32294654-11	2020	RESULTS: Treating cultured hCMEC/D3 human cells with poly IC induced the expression of CXCL1 as well as another chemokine CXCL8.	Poly I-C	53-60	C-X-C motif chemokine ligand 8	Homo sapiens	122-127	
31534438-6	2019	We found that poly I:C induced increased expression of the proinflammatory cytokines IL1beta, IL6, CXCL8, and TNF and IFN-beta1 in AECs from both control subjects and COPD patients.	Poly I-C	14-22	C-X-C motif chemokine ligand 8	Homo sapiens	99-104	
31049957-7	2019	RESULTS: Production of IL-6, IL-8, MCP-1, and OPG was significantly increased by Poly I:C or Pam3CSK4 to a similar extent.	Poly I-C	81-89	C-X-C motif chemokine ligand 8	Homo sapiens	29-33	
29245047-0	2018	Polyriboinosinic-polyribocytidylic acid facilitates interleukin-6, and interleukin-8 secretion in human dermal fibroblasts via the JAK/STAT3 and p38 MAPK signal transduction pathways.	Poly I-C	0-39	C-X-C motif chemokine ligand 8	Homo sapiens	71-84	
31333667-4	2019	PolyI:C increased the expression of interferon-beta (IFN-beta), interleukin-6 (IL-6), interleukin-8 (IL-8), monocyte chemoattractant protein (MCP-1), and interleukin-1beta (IL-1beta) in HCT116 cells, and these up-regulations were significantly altered when cells were pre-stimulated with LAB isolated from Korean fermented foods.	Poly I-C	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	86-99	
31333667-4	2019	PolyI:C increased the expression of interferon-beta (IFN-beta), interleukin-6 (IL-6), interleukin-8 (IL-8), monocyte chemoattractant protein (MCP-1), and interleukin-1beta (IL-1beta) in HCT116 cells, and these up-regulations were significantly altered when cells were pre-stimulated with LAB isolated from Korean fermented foods.	Poly I-C	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	101-105	
33911592-7	2019	Results: When skin keratinocytes were pre-treated with SAA, it significantly inhibited poly (I:C)-induced expression of inflammatory cytokines including interleukin (IL)-1beta, IL-6, IL-8, tumor necrosis factor-alpha, and CCL20.	Poly I-C	87-97	C-X-C motif chemokine ligand 8	Homo sapiens	183-187	
29940963-6	2018	RESULTS: TBEC and AMs showed stronger pro-inflammatory cytokine (e.g., IL-8) responses to PIC and LPS, respectively.	Poly I-C	90-93	C-X-C motif chemokine ligand 8	Homo sapiens	71-75	
29940963-11	2018	PIC-stimulated TBEC and LPS-stimulated AMs from smokers vs. non-smokers produced more IL-8.	Poly I-C	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	86-90	
29245047-7	2018	In conclusion, polyI:C induces IL-6 and IL-8 production in HDFs via the JAK/STAT3 and p38 MAPK signaling pathways.	Poly I-C	15-22	C-X-C motif chemokine ligand 8	Homo sapiens	40-44	
30295964-4	2018	RESULTS: Poly (I:C) induced the expression of the interferon-stimulated genes (ISG) MxA, OAS2 and APOBEC3G, and the cytokines MCP-1, IL-8, IL-6, CCL20, IFNbeta and RANTES by fibroblasts from all three sites.	Poly I-C	9-19	C-X-C motif chemokine ligand 8	Homo sapiens	133-137	
29245047-3	2018	Here, we found that polyI:C enhances IL-6 and IL-8 mRNA expression and induces of IL-6 and IL-8 production in a concentration-dependent and time-dependent manner in HDFs.	Poly I-C	20-27	C-X-C motif chemokine ligand 8	Homo sapiens	46-50	
29245047-3	2018	Here, we found that polyI:C enhances IL-6 and IL-8 mRNA expression and induces of IL-6 and IL-8 production in a concentration-dependent and time-dependent manner in HDFs.	Poly I-C	20-27	C-X-C motif chemokine ligand 8	Homo sapiens	91-95	
29245047-5	2018	Moreover, pretreatment with AG490, a Janus kinase (JAK) inhibitor, inhibited polyI:C-induced STAT3 phosphorylation and subsequent IL-6 and IL-8 release.	Poly I-C	77-84	C-X-C motif chemokine ligand 8	Homo sapiens	139-143	
28438134-0	2017	Poly I:C induces collective migration of HaCaT keratinocytes via IL-8.	Poly I-C	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	65-69	
28363866-9	2017	Transfection of poly(I-C) enhanced IL8 and BST2 mRNA expression and inhibited HBsAg secretion from PLC/PRF/5 cells.	Poly I-C	16-25	C-X-C motif chemokine ligand 8	Homo sapiens	35-38	
28438134-8	2017	Poly I:C also increased IL-8 and bFGF production, and anti-IL-8 antibodies significantly inhibited the migration caused by poly I:C.	Poly I-C	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	24-28	
28438134-8	2017	Poly I:C also increased IL-8 and bFGF production, and anti-IL-8 antibodies significantly inhibited the migration caused by poly I:C.	Poly I-C	123-131	C-X-C motif chemokine ligand 8	Homo sapiens	59-63	
28438134-12	2017	CONCLUSION: Our findings demonstrated that poly I:C accelerated collective HaCaT cell migration via autocrine/paracrine secretions of IL-8 and the subsequent incomplete epithelial-mesenchymal transition (EMT).	Poly I-C	43-51	C-X-C motif chemokine ligand 8	Homo sapiens	134-138	
26418032-3	2015	In this study, we demonstrated that IL-17A and polyI:C, the ligand of TLR3, synergistically induced the expression of proinflammatory cytokines and chemokines (G-CSF, IL-8, CXCL1, CXCL5, IL-1F9), but not type I interferon (IFN-alpha1, -beta) in primary culture of normal human bronchial epithelial cells.	Poly I-C	47-54	C-X-C motif chemokine ligand 8	Homo sapiens	167-171	
28052863-5	2017	Poly(I:C) increased the production of IL-6, IL-8, monocyte chemoattractant protein-1, and ICAM-1.	Poly I-C	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	44-48	
27210890-7	2016	KEY FINDINGS: RA significantly inhibited poly(I:C)-induced expression of inflammatory cytokines including IL-1beta, IL-6, IL-8, CCL20, and TNF-alpha, and downregulated NF-kappaB signaling pathway in human keratinocytes.	Poly I-C	41-50	C-X-C motif chemokine ligand 8	Homo sapiens	122-126	
26477783-6	2016	RESULTS: LPS, fMLP, imiquimod and R848 stimulated the release of CXCL8, NE and MMP-9 whereas poly I:C selectively induced CXCL8 release only.	Poly I-C	93-101	C-X-C motif chemokine ligand 8	Homo sapiens	122-127	
25652132-8	2015	The TLR3 agonist poly I:C 10 mug/mL increased the IL-8 release in HBECs that was poorly inhibited by dexamethasone in smokers (24.5%) and smokers with COPD (21.6%).	Poly I-C	17-25	C-X-C motif chemokine ligand 8	Homo sapiens	50-54	
25803620-5	2015	Both intracellular and extracellular poly(I:C) induced the expression of IFNB, TNF, IL6, and IL8.	Poly I-C	37-45	C-X-C motif chemokine ligand 8	Homo sapiens	93-96	
25532794-8	2015	Poly(I:C) induced activation of TLR-2 contributes to stronger cell responses to a TLR-2 agonist and regulation of these synergistic responses may take place at the mRNA level of IL-6 and IL-8.	Poly I-C	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	187-191	
26283481-9	2015	In contrast, we show that stimulation of the RIG-I/MAVS pathway, such as when poly(I:C) is delivered intracellularly in a complex with liposomes or via nucleofection, selectively stimulates IFN-beta with low IL-8 costimulation.	Poly I-C	78-87	C-X-C motif chemokine ligand 8	Homo sapiens	208-212	
26191223-6	2015	PE significantly inhibited poly (I:C)-induced expression of crucial psoriatic cytokines, such as IL-6, IL-8, CCL20 and TNF-alpha, via down-regulation of NF-kappaB signaling pathway in human keratinocytes.	Poly I-C	27-37	C-X-C motif chemokine ligand 8	Homo sapiens	103-107	
25264520-10	2014	Human AEC pre-treated with IL-4 and IL-13, then stimulated with poly I:C, similarly exhibited significantly higher expression of IL8, CXCL9, CXCL10, CXCL11 and CCL5 genes.	Poly I-C	64-72	C-X-C motif chemokine ligand 8	Homo sapiens	129-132	
25055998-7	2015	We also found that poly-IC-induced mRNA expression of other proinflammatory mediators such as MCP-1, RANTES, and IL-8 was suppressed by licochalcone A.	Poly I-C	19-26	C-X-C motif chemokine ligand 8	Homo sapiens	113-117	
25608815-4	2015	The results showed that, most of the cytokines or receptors had obvious expression change compared with the control (without Poly I:C stimulation), especially the three cytokine genes IL6, IL8 and IL10, whose average expression change times were 20.71, 10.87 and 5.18, respectively.	Poly I-C	125-133	C-X-C motif chemokine ligand 8	Homo sapiens	189-192	
23911868-4	2013	Although short poly I:C (  1-1.5 kb) induced greater amounts of TNF-alpha, IL-8, and IFN-beta and a stronger antiviral response in myeloid cells, it was a poor inducer in fibroblasts.	Poly I-C	15-23	C-X-C motif chemokine ligand 8	Homo sapiens	75-79	
25478290-9	2014	Reduction of MUC18 serine phosphorylation by inhibiting ERK activity was associated with less production of IL-8 following polyI:C stimulation.	Poly I-C	123-130	C-X-C motif chemokine ligand 8	Homo sapiens	108-112	
22749216-5	2013	Simultaneous treatment of cells with DNA and dsRNA analog poly(I:C) leads to inhibition of poly(I:C)-activated secretion of IL-6 and IL-8.	Poly I-C	58-66	C-X-C motif chemokine ligand 8	Homo sapiens	133-137	
22749216-5	2013	Simultaneous treatment of cells with DNA and dsRNA analog poly(I:C) leads to inhibition of poly(I:C)-activated secretion of IL-6 and IL-8.	Poly I-C	58-67	C-X-C motif chemokine ligand 8	Homo sapiens	133-137	
22762377-3	2012	While poly(I:C) induced IL-8 gene expression was solely inhibited by the NF-kappaB inhibitor III, MCP-1 gene induction was also blocked by PKA, p38 MAPK and JAK-STAT inhibitors.	Poly I-C	6-14	C-X-C motif chemokine ligand 8	Homo sapiens	24-28	
24459828-10	2013	Stimulation with PolyI:C, Pam3CSK4 and LPS also lead to considerable increase of NF-kBp65, while increased levels of inflammatory cytokines were observed for IL-8, TNF and IL-6 in cells treated with PMA and MeV.	Poly I-C	17-24	C-X-C motif chemokine ligand 8	Homo sapiens	158-162	
22984986-5	2013	RESULTS: EC from all FRT compartments constitutively expressed NOD1, NOD2, RIG-1, and MDA5 with highest levels expressed by FT. Stimulation with poly(I:C) resulted in upregulation of NOD2, RIG-1, and MDA5 in all FRT compartments and correlated with increased secretion of IL-8, whereas estradiol treatment had no effects.	Poly I-C	145-153	C-X-C motif chemokine ligand 8	Homo sapiens	272-276	
22954322-7	2013	Whereas the poly(I:C)-induced secretion of IL-6, IP-10, and RANTES was inhibited by both IKK-2 inhibitor and LY294002, that of IL-8 was blocked only by IKK-2 inhibitor.	Poly I-C	12-21	C-X-C motif chemokine ligand 8	Homo sapiens	127-131	
22954322-8	2013	CONCLUSIONS: The poly(I:C)-induced secretion of IL-6, IP-10, and RANTES from human corneal fibroblasts is mediated by both NF-kappaB and PI3K signaling pathways, whereas that of IL-8 is mediated by the NF-kappaB pathway.	Poly I-C	17-26	C-X-C motif chemokine ligand 8	Homo sapiens	178-182	
22762377-6	2012	These data are indicative for distinct signalling pathways in the poly(I:C)-induced gene expression of IL-8 and MCP-1 in HaCaT keratinocytes.	Poly I-C	66-75	C-X-C motif chemokine ligand 8	Homo sapiens	103-107	
20932985-5	2011	In hTERT-transfected HNECs, treatment with poly(I:C) significantly reduced expression of the tight junction protein JAM-A and induced secretion of proinflammatory cytokines IL-8 and TNF-alpha.	Poly I-C	43-51	C-X-C motif chemokine ligand 8	Homo sapiens	173-177	
22310660-4	2012	Consequently, induction of cytokines interleukin-8 and beta interferon after poly(I   C) stimulation was impaired in Rb(-/-) MEF and Rb siRNA-transfected cells compared to controls.	Poly I-C	77-88	C-X-C motif chemokine ligand 8	Homo sapiens	37-50	
22116002-6	2012	Poly(I:C) stimulated the secretion of IL-6, IL-8, MCP-1, RANTES, IP-10, eotaxin, MIP-1beta, and interferon-gamma, whereas zymosan triggered the production of IL-6, IL-8, and MCP-1.	Poly I-C	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	44-48	
22116002-6	2012	Poly(I:C) stimulated the secretion of IL-6, IL-8, MCP-1, RANTES, IP-10, eotaxin, MIP-1beta, and interferon-gamma, whereas zymosan triggered the production of IL-6, IL-8, and MCP-1.	Poly I-C	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	164-168	
22116002-7	2012	LPS, poly(I:C), and zymosan thus each induced a distinct pattern of cytokine and chemokine release from human corneal fibroblasts, with the release of IL-6, IL-8, and MCP-1 being commonly elicited by all three agents.	Poly I-C	5-14	C-X-C motif chemokine ligand 8	Homo sapiens	157-161	
21715345-10	2011	A significant increase in expression levels of IL-6, TNF-alpha, IL-8, MCP-1, ICAM-1, and BFGF was observed after poly (I:C) RNA stimulation (P < 0.05).	Poly I-C	113-123	C-X-C motif chemokine ligand 8	Homo sapiens	64-68	
21337319-8	2011	Stimulation with poly(I-C) induced the activation of IFN regulatory factor 3 (IRF-3), NF-kappaB, and activator protein 1 (AP-1) c-Jun as well as the subsequent production of IFNbeta, CXCL8, and MMP-3.	Poly I-C	17-25	C-X-C motif chemokine ligand 8	Homo sapiens	183-188	
20657019-1	2010	BACKGROUND: The authors previously reported that human ocular surface epithelium expressed TLR3 and that its ligand polyI:C stimulated the secretion of IL-6, IL-8 and IFN-beta.	Poly I-C	116-123	C-X-C motif chemokine ligand 8	Homo sapiens	158-162	
20456615-9	2010	IL-6 and IL-8 production was increased by Pam(3) CSK(4) , flagellin, Poly I:C, and imiquimod, but not lipopolysaccharide (LPS).	Poly I-C	69-77	C-X-C motif chemokine ligand 8	Homo sapiens	9-13	
19752565-10	2010	Stimulation with poly(I:C) increased the percentage of CD11b+ cells and enhanced the secretion of IL-8, effects mediated via the p38 mitogen-activated protein kinases and nuclear factor-kappaB signaling pathways.	Poly I-C	17-26	C-X-C motif chemokine ligand 8	Homo sapiens	98-102	
19752565-11	2010	Moreover, pretreatment with IL-5 augmented the poly(I:C)-induced IL-8 release.	Poly I-C	47-56	C-X-C motif chemokine ligand 8	Homo sapiens	65-69	
19522763-4	2009	In addition, poly I:C treatment inhibited cell growth and triggered up-regulation of IL-12p40, IL-8 and Il-1alpha in Detroit 562 cell line.	Poly I-C	13-21	C-X-C motif chemokine ligand 8	Homo sapiens	95-99	
19779021-5	2009	Using the cytokine IL-8 as a physiological read out of the inflammatory response, we found that TLR3 is the most functional of the expressed TLRs in both primary and immortalized esophageal epithelial cell lines in response to its synthetic ligand polyinosinic polycytidylic acid [poly(I:C)].	Poly I-C	248-279	C-X-C motif chemokine ligand 8	Homo sapiens	19-23	
19779021-6	2009	Through reporter gene studies, we show that poly(I:C)-induced NF-kappaB activation is critical for the transactivation of the IL-8 promoter in vitro and that nuclear translocation of NF-kappaB occurs at an early time point following poly(I:C) stimulation of esophageal epithelial cells.	Poly I-C	44-53	C-X-C motif chemokine ligand 8	Homo sapiens	126-130	
19779021-6	2009	Through reporter gene studies, we show that poly(I:C)-induced NF-kappaB activation is critical for the transactivation of the IL-8 promoter in vitro and that nuclear translocation of NF-kappaB occurs at an early time point following poly(I:C) stimulation of esophageal epithelial cells.	Poly I-C	44-52	C-X-C motif chemokine ligand 8	Homo sapiens	126-130	
19740321-9	2009	Poly(I:C) induced a small increase in IL-1beta, IL-6 and IL-8 production in HNECs, while Pam(3)CSK(4) increased viability.	Poly I-C	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	57-61	
19527294-5	2009	Treatment of bronchial epithelial cells with LL-37 and the TLR3 agonist polyI:C resulted in synergistic increases in IL-8 release and cytotoxicity.	Poly I-C	72-79	C-X-C motif chemokine ligand 8	Homo sapiens	117-121	
18660424-7	2008	RESULTS: Poly(I:C) induced the up-regulation of TLR3, the release of IL-6, IL-8, G-CSF, MIP-1beta, eotaxin, and RANTES, and the expression of ICAM-1 and VCAM-1 in corneal fibroblasts.	Poly I-C	9-17	C-X-C motif chemokine ligand 8	Homo sapiens	75-79	
19452017-10	2009	The poly(I:C)-induced expressions of IL-6 and IL-8 were down-regulated by both DEX and CsA, while the expressions of IFN-beta and TLR3 were suppressed by DEX alone.	Poly I-C	4-12	C-X-C motif chemokine ligand 8	Homo sapiens	46-50	
19146941-5	2009	RESULTS: HaCaT cells induced the pro-inflammatory cytokines, interleukin-8 (IL-8) and/or interleukin-6 (IL-6) expressions after treatment with polyI:C or PGN.	Poly I-C	143-150	C-X-C motif chemokine ligand 8	Homo sapiens	61-74	
19146941-5	2009	RESULTS: HaCaT cells induced the pro-inflammatory cytokines, interleukin-8 (IL-8) and/or interleukin-6 (IL-6) expressions after treatment with polyI:C or PGN.	Poly I-C	143-150	C-X-C motif chemokine ligand 8	Homo sapiens	76-80	
18660424-9	2008	Poly(I:C)-induced expression of IL-6, IL-8, G-CSF, MIP-1beta, exotaxin, RANTES, and ICAM-1 was inhibited differentially by the MAPK inhibitors PD98059 and SB203580 and by JNK inhibitor II.	Poly I-C	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	38-42	
18779317-9	2008	Consequently, induction of interleukin-8 and beta interferon after poly(I-C) stimulation was impaired in HCT116 p53(-/-) cells.	Poly I-C	67-76	C-X-C motif chemokine ligand 8	Homo sapiens	27-40	
17202379-7	2007	Surprisingly, the TLR9 ligand CpG oligodeoxynucleotide 2006 was able to specifically inhibit poly(I:C)-induced IL-8 and IDO expression.	Poly I-C	93-102	C-X-C motif chemokine ligand 8	Homo sapiens	111-115	
18424663-5	2008	CBMCs responded to stimulation with polyinosinic.polycytidylic acid by producing a distinct chemokine profile, including CCL4, CXCL8, and CXCL10.	Poly I-C	36-67	C-X-C motif chemokine ligand 8	Homo sapiens	127-132	
17043099-4	2007	RESULTS: Polyriboinosinic:polyribocytidylic acid (poly I:C), a synthetic dsRNA that antagonizes TLR3, stimulated the secretion of IL-6, IL-8 and GCP-2 by OECs.	Poly I-C	9-48	C-X-C motif chemokine ligand 8	Homo sapiens	136-140	
17043099-4	2007	RESULTS: Polyriboinosinic:polyribocytidylic acid (poly I:C), a synthetic dsRNA that antagonizes TLR3, stimulated the secretion of IL-6, IL-8 and GCP-2 by OECs.	Poly I-C	50-58	C-X-C motif chemokine ligand 8	Homo sapiens	136-140	
16406095-8	2006	Moreover, histamine enhanced poly (I:C)-induced IL-8 secretion and phosphorylation of NF-kappaB in the two cell types, and histamine H1 receptor antagonists inhibited the action of histamine.	Poly I-C	29-39	C-X-C motif chemokine ligand 8	Homo sapiens	48-52	
17063122-6	2006	After activation with polyinosinic-polycytidylic acid, BDCs expressed higher levels of major histocompatibility complex class I, CD40, CD80, and CD83, and secreted higher levels of tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, and IL-8 compared with MoDCs.	Poly I-C	22-53	C-X-C motif chemokine ligand 8	Homo sapiens	244-248	
16406095-10	2006	Histamine also enhanced poly (I:C) induced IL-8 secretion and phosphorylation of NF-kappaB.	Poly I-C	24-33	C-X-C motif chemokine ligand 8	Homo sapiens	43-47	
15845391-4	2005	Stimulation with polyI:C elicited the elevated production and mRNA expression of IL-6 and IL-8 in HCEC.	Poly I-C	17-24	C-X-C motif chemokine ligand 8	Homo sapiens	90-94	
15265658-10	2004	Poly I:C treatment of RPE resulted in an increase in the production of IL-6, IL-8, MCP-1, and sICAM-1.	Poly I-C	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	77-81	
16265667-6	2006	Furthermore, our studies on the intracellular signaling pathways reveal that poly(I:C) stimulation activates IkappaB kinase (IKK), extracellular signal-regulated kinase (ERK), and c-Jun N-terminal kinase (JNK) in CRT-MG. Pharmacological inhibitors of nuclear factor-kappaB (NF-kappaB), JNK, ERK, glycogen synthase kinase-3beta (GSK-3beta), and dsRNA-activated protein kinase (PKR) inhibit the expression of IL-8 and IP-10 in astrocytes, indicating that the activation of these signaling molecules is required for the TLR3-mediated chemokine gene induction.	Poly I-C	77-86	C-X-C motif chemokine ligand 8	Homo sapiens	407-411	
15879132-4	2005	Poly(I:C)-induced IL-8 was concentration dependent (2-100 mug/ml) and displayed slower kinetics compared with IL-8 induced by bacterial flagellin (ET(50) approximately 24 vs 8 h poly(I:C) vs flagellin, respectively).	Poly I-C	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	18-22