PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22206014-3	2011	We set out to delineate the essential signaling pathways by which the RNA-like IRMs, resiquimod (R-848) and polyinosinic:polycytidylic acid (poly I:C), augment CD4+ T-helper 1 (Th1) responses.	Poly I-C	108-139	CD4 antigen	Mus musculus	160-163	
20008077-5	2011	In addition, poly I:C led to evident alternations in neuroendocrine and immune systems of mice, such as reduced spontaneous activity and learning ability, declined serum level of corticosterone, increased weight indexes and T lymphocyte numbers in thymuses and spleens, and increased CD4(+)/CD8(+) ratio but decreased proliferation ability of T lymphocytes in spleens.	Poly I-C	13-21	CD4 antigen	Mus musculus	284-287	
21070856-5	2011	Poly I:C-induced a marked pulmonary T cell response in allogeneic HCT mice as compared to syngeneic HCT, with increased CD4+ cells in the lung fluid and tissue.	Poly I-C	0-8	CD4 antigen	Mus musculus	120-123	
21070856-8	2011	In vivo, poly I:C exposure was associated with an early increase in pulmonary monocyte recruitment and activation as well as a decrease in CD4+FOXP3+ regulatory T cells in allogeneic mice as compared to syngeneic.	Poly I-C	9-17	CD4 antigen	Mus musculus	139-142	
20980632-4	2010	In vivo administration of CpG, polyinosinic-polycytidylic acid, and Pam(3)CSK(4) in combination with Ag resulted in the increased expression of costimulatory molecules and MHC class II by DCs, increased serum levels of the inflammatory cytokines IL-6 and RANTES, and increased cognate CD4 T cell responses in young and aged mice.	Poly I-C	31-62	CD4 antigen	Mus musculus	285-288	
19418018-0	2009	Resistance to activation-induced cell death and elevated FLIPL expression of CD4+ T cells in a polyI:C-induced primary biliary cirrhosis mouse model.	Poly I-C	95-102	CD4 antigen	Mus musculus	77-80	
19418018-2	2009	We established a PBC animal model by injecting C57BL/6 mice with polyI:C to study activation-induced cell death (AICD) in CD4+ T lymphocytes and changes of apoptosis-associated molecules as a first step to understand the immune tolerance of PBC mice.	Poly I-C	65-72	CD4 antigen	Mus musculus	122-125	
18194666-0	2008	Combined insulin B:9-23 self-peptide and polyinosinic-polycytidylic acid accelerate insulitis but inhibit development of diabetes by increasing the proportion of CD4+Foxp3+ regulatory T cells in the islets in non-obese diabetic mice.	Poly I-C	41-72	CD4 antigen	Mus musculus	162-165	
19564349-1	2009	Relative to several other toll-like receptor (TLR) agonists, we found polyinosinic:polycytidylic acid (poly IC) to be the most effective adjuvant for Th1 CD4(+) T cell responses to a dendritic cell (DC)-targeted HIV gag protein vaccine in mice.	Poly I-C	103-110	CD4 antigen	Mus musculus	154-157	
19380818-7	2009	In addition, administration of poly(I:C), which is an innate immune agonist, to TMEV-infected mice during the innate immune response resulted in decreased myelin-specific CD4(+) T cell responses and reduced demyelinating disease.	Poly I-C	31-39	CD4 antigen	Mus musculus	171-174	
17471165-0	2007	CD4+ T helper cell response is required for memory in CD8+ T lymphocytes induced by a poly(I:C)-adjuvanted MHC I-restricted peptide epitope.	Poly I-C	86-95	CD4 antigen	Mus musculus	0-3	
28250157-2	2017	We find that using APC pretreated ex vivo with TLR agonists, polyinosinic-polycytidylic acid and CpG, to prime naive CD4 T cells in vivo, restores their ability to expand and become germinal center T follicular helpers and enhances B cell IgG Ab production.	Poly I-C	61-92	CD4 antigen	Mus musculus	117-120	
25257859-8	2015	However, the CD4(+) T cell response, as monitored by IFN-gamma, was significantly increased in mice given polyI:C+MmSVN2B.	Poly I-C	106-113	CD4 antigen	Mus musculus	13-16	
25257859-11	2015	These results suggest that activated, self-reactive CD4(+) helper T cells proliferate in MmSVN2B+polyI:C immunization and contribute to Th1 polarization followed by antibody production, but hardly participate in CTL induction.	Poly I-C	97-104	CD4 antigen	Mus musculus	52-55