PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18306459-9 2008 When cells were stimulated by poly (I:C), 3-phenyl-propenal significantly decreased TLR3 and MyD88 expression. Poly I-C 30-40 myeloid differentiation primary response gene 88 Mus musculus 93-98 32824595-7 2020 Corroborating in vitro data, Myd88-/- knockout mice downregulated TNF, CXCL1; and phospho-p65 and phospho-IRF3 nuclear localization, upon poly I:C treatment in a mouse model of skin infection. Poly I-C 138-146 myeloid differentiation primary response gene 88 Mus musculus 29-34 30550930-9 2019 To validate the effects of poly(I:C) were mediated through MyD88, we tested female mice lacking Myd88. Poly I-C 27-36 myeloid differentiation primary response gene 88 Mus musculus 59-64 30550931-11 2019 MyD88 null mutants showed poly(I:C)-induced increases in alcohol intake. Poly I-C 26-35 myeloid differentiation primary response gene 88 Mus musculus 0-5 20006962-6 2010 Additional experiments utilizing CpG and Poly I:C stimulation to selectively activate the MyD88-dependent and -independent pathways via TLR9 and TLR3 substantiated the finding that malyngamide F acetate selectively inhibits the MyD88-dependent pathway. Poly I-C 41-49 myeloid differentiation primary response gene 88 Mus musculus 90-95 16585964-6 2006 Nrf2-deficient mouse embryonic fibroblasts showed greater activation of NF-kappaB and interferon regulatory factor 3 in response to LPS and polyinosinic-polycytidylic acid [poly(I:C)] stimulus, corroborating the effect of Nrf2 on MyD88-dependent and -independent signaling. Poly I-C 140-171 myeloid differentiation primary response gene 88 Mus musculus 230-235