PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32037657-3 2020 Furthermore, we found that HSP60 could interact with mitochondrial antiviral signaling protein (MAVS), an important signal transduction protein for inducing production of type I interferon, and promote polyI:C-mediated the production of type I interferon in a MAVS-dependent manner. Poly I-C 202-209 mitochondrial antiviral signaling protein Homo sapiens 53-94 33219146-4 2021 In this study, we show that NUDT21, an RNA-binding protein that regulates alternative transcript polyadenylation, physically associates with IPS-1 and mediates its localization to SGs in response to transfection with polyinosinic-polycytidylic acid [poly(I:C)], a mimic of viral dsRNA. Poly I-C 217-248 mitochondrial antiviral signaling protein Homo sapiens 141-146 33219146-4 2021 In this study, we show that NUDT21, an RNA-binding protein that regulates alternative transcript polyadenylation, physically associates with IPS-1 and mediates its localization to SGs in response to transfection with polyinosinic-polycytidylic acid [poly(I:C)], a mimic of viral dsRNA. Poly I-C 250-259 mitochondrial antiviral signaling protein Homo sapiens 141-146 32037657-3 2020 Furthermore, we found that HSP60 could interact with mitochondrial antiviral signaling protein (MAVS), an important signal transduction protein for inducing production of type I interferon, and promote polyI:C-mediated the production of type I interferon in a MAVS-dependent manner. Poly I-C 202-209 mitochondrial antiviral signaling protein Homo sapiens 96-100 32037657-3 2020 Furthermore, we found that HSP60 could interact with mitochondrial antiviral signaling protein (MAVS), an important signal transduction protein for inducing production of type I interferon, and promote polyI:C-mediated the production of type I interferon in a MAVS-dependent manner. Poly I-C 202-209 mitochondrial antiviral signaling protein Homo sapiens 260-264 29509510-0 2018 Epicutaneous administration of the pattern recognition receptor agonist polyinosinic-polycytidylic acid activates the MDA5/MAVS pathway in Langerhans cells. Poly I-C 72-103 mitochondrial antiviral signaling protein Homo sapiens 123-127 28141795-3 2017 Here we demonstrated that MAVS signaling existed and mediated poly(I:C)-induced inflammation in the brain. Poly I-C 62-71 mitochondrial antiviral signaling protein Homo sapiens 26-30 23601685-0 2013 Poly IC triggers a cathepsin D- and IPS-1-dependent pathway to enhance cytokine production and mediate dendritic cell necroptosis. Poly I-C 0-7 mitochondrial antiviral signaling protein Homo sapiens 36-41 27705941-0 2016 MicroRNA-22 negatively regulates poly(I:C)-triggered type I interferon and inflammatory cytokine production via targeting mitochondrial antiviral signaling protein (MAVS). Poly I-C 33-42 mitochondrial antiviral signaling protein Homo sapiens 122-163 27705941-0 2016 MicroRNA-22 negatively regulates poly(I:C)-triggered type I interferon and inflammatory cytokine production via targeting mitochondrial antiviral signaling protein (MAVS). Poly I-C 33-42 mitochondrial antiviral signaling protein Homo sapiens 165-169 25225670-6 2014 Mechanistically, Mavs triggered membrane permeabilization and K(+) efflux independently of the inflammasome which were required for poly(I:C)-induced Nlrp3 activation. Poly I-C 132-141 mitochondrial antiviral signaling protein Homo sapiens 17-21 25225670-7 2014 We conclude that poly (I:C) activates the inflammasome through an Mavs-dependent surveillance pathway that converges into a common K(+) lowering step in the cytosol that is essential for the induction of Nlrp3 activation. Poly I-C 17-26 mitochondrial antiviral signaling protein Homo sapiens 66-70 26283481-9 2015 In contrast, we show that stimulation of the RIG-I/MAVS pathway, such as when poly(I:C) is delivered intracellularly in a complex with liposomes or via nucleofection, selectively stimulates IFN-beta with low IL-8 costimulation. Poly I-C 78-87 mitochondrial antiviral signaling protein Homo sapiens 51-55 23601685-4 2013 Upon poly IC stimulation, cathepsin D was released into the cytoplasm from the lysosome to interact with IPS-1, an adaptor molecule for RLRs. Poly I-C 5-12 mitochondrial antiviral signaling protein Homo sapiens 105-110 19635904-9 2009 Taken together, poly I:C activates the IPS-1- and TRIF-dependent pathways in CD8alpha(+) cDCs, which in turn leads to NK cell activation. Poly I-C 16-24 mitochondrial antiviral signaling protein Homo sapiens 39-44 23028806-4 2012 Here, we report that MAVS mRNA is degraded in response to polyinosinic-polycytidylic acid (polyI:C), a synthetic dsRNA, in A549 cells. Poly I-C 58-89 mitochondrial antiviral signaling protein Homo sapiens 21-25 23028806-4 2012 Here, we report that MAVS mRNA is degraded in response to polyinosinic-polycytidylic acid (polyI:C), a synthetic dsRNA, in A549 cells. Poly I-C 91-98 mitochondrial antiviral signaling protein Homo sapiens 21-25 23028806-7 2012 In the resting state, the MAVS protein was protected from degradation by interferon regulatory factor 3 (IRF3); moreover, the dimerization of IRF3 appeared to be correlated with the rescue of protein degradation in response to polyI:C. Poly I-C 227-234 mitochondrial antiviral signaling protein Homo sapiens 26-30 23028806-8 2012 The overexpression of MAVS enhanced interferon-beta (IFN-beta) expression in response to polyI:C, suggesting that the degradation of MAVS contributes to the suppression of the hyper-immune reaction in late-phase antiviral signaling. Poly I-C 89-96 mitochondrial antiviral signaling protein Homo sapiens 22-26 23028806-8 2012 The overexpression of MAVS enhanced interferon-beta (IFN-beta) expression in response to polyI:C, suggesting that the degradation of MAVS contributes to the suppression of the hyper-immune reaction in late-phase antiviral signaling. Poly I-C 89-96 mitochondrial antiviral signaling protein Homo sapiens 133-137 19635904-0 2009 Poly I:C-induced activation of NK cells by CD8 alpha+ dendritic cells via the IPS-1 and TRIF-dependent pathways. Poly I-C 0-8 mitochondrial antiviral signaling protein Homo sapiens 78-83 19635904-6 2009 Furthermore, both IPS-1 and TRIF contributed to suppression of implanted B16 tumor growth in response to poly I:C administration via NK cell activation. Poly I-C 105-113 mitochondrial antiviral signaling protein Homo sapiens 18-23 19635904-7 2009 Presence of IPS-1 and TRIF in dendritic cells (DCs), but not NK cells, was required for production of IFN-gamma to poly I:C in NK cells in vitro. Poly I-C 115-123 mitochondrial antiviral signaling protein Homo sapiens 12-17 19669308-9 2008 The induction of IFN-beta mRNA was efficiently inhibited by an siRNA against MAVS but not against TICAM-1, indicating that the main signaling pathway for IFN-beta induction following polyI:C transfection is via retinoic acid-inducible gene I (RIG-I)/melanoma differentiation-associated gene 5 (MDA5) in HIBECs. Poly I-C 183-190 mitochondrial antiviral signaling protein Homo sapiens 77-81