PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27834952-4	2017	PolyI:C-induced inhibition of tumor growth was attributed to caspase-8/3 cascade activation in tumor cells that occurred independently of CD8alpha+/CD103+ dendritic cells (DCs) and CTLs.	Poly I-C	0-7	caspase 8	Homo sapiens	61-70	
35151092-5	2022	Importantly, the combination of poly(I:C) with proteasome inhibitors enhanced caspase-8 and caspase-9 activation, and synergistically induced cervical cancer cell apoptosis.	Poly I-C	32-41	caspase 8	Homo sapiens	78-87	
28849057-12	2017	Following the downregulation of TIPE2 the aforementioned effect of Poly I:C treatment was reversed and may be associated with the reduced activity of caspase-8 that was observed in the TIPE2 silenced group.	Poly I-C	67-75	caspase 8	Homo sapiens	150-159	
30320341-7	2018	Poly(I:C)-HMW induced the expression of active caspase-8 and -9, and the Poly(I:C)-HMW-induced increase in the cell cycle sub-G1 population, which is one of the hallmarks of apoptosis, was decreased by treatment with a caspase-8 inhibitor and caspase-9 inhibitor.	Poly I-C	0-9	caspase 8	Homo sapiens	47-63	
30320341-7	2018	Poly(I:C)-HMW induced the expression of active caspase-8 and -9, and the Poly(I:C)-HMW-induced increase in the cell cycle sub-G1 population, which is one of the hallmarks of apoptosis, was decreased by treatment with a caspase-8 inhibitor and caspase-9 inhibitor.	Poly I-C	0-9	caspase 8	Homo sapiens	47-56	
30320341-8	2018	When cells were treated with Poly(I:C)-HMW and IR, the sub-G1 population, and the active caspase-8 and caspase-9 expression were all increased compared with cells treated with Poly(I:C)-HMW or IR alone.	Poly I-C	29-38	caspase 8	Homo sapiens	89-98	
30320341-10	2018	Notably, treatment with an inhibitor for caspase-8, not caspase-9, partially reversed the net increase in the sub-G1 population induced by cotreatment with Poly(I:C)-HMW and IR.	Poly I-C	156-164	caspase 8	Homo sapiens	41-50	
30320341-11	2018	Collectively, these results suggested that Poly(I:C)-HMW induces apoptosis through caspase-8 and caspase-9 activation; however, the apoptotic pathway mediated by casapse-8, and not casapse-9, is involved in the enhancement of apoptosis caused by cotreatment with Poly(I:C)-HMW and IR.	Poly I-C	43-52	caspase 8	Homo sapiens	83-92	
20019748-4	2010	Instead, poly I:C-induced activation of caspase-8 via TLR3 and its adapter TRIF was required for apoptosis.	Poly I-C	9-17	caspase 8	Homo sapiens	40-49	
25227113-8	2014	Immunoblots and assays with a panel of caspase inhibitors revealed that poly(I:C) transfection-induced apoptosis was dependent on caspase-8 and -9, as well as caspase-2.	Poly I-C	72-80	caspase 8	Homo sapiens	130-146	
22187010-4	2012	Bafilomycin A1, an inhibitor of ER function, effectively blocked poly(I:C)-induced activation of caspase-8, -9, and -3, MnSOD and glutathione peroxidase 1 and reduced poly(I:C)-induced SK-N-AS apoptosis.	Poly I-C	65-74	caspase 8	Homo sapiens	97-118	
22187010-4	2012	Bafilomycin A1, an inhibitor of ER function, effectively blocked poly(I:C)-induced activation of caspase-8, -9, and -3, MnSOD and glutathione peroxidase 1 and reduced poly(I:C)-induced SK-N-AS apoptosis.	Poly I-C	65-73	caspase 8	Homo sapiens	97-118	
21697465-3	2011	Poly(I   C), a synthetic analogue of viral dsRNA, rapidly triggers caspase 8 activation and apoptosis in HeLa cells.	Poly I-C	0-10	caspase 8	Homo sapiens	67-76	
21697465-6	2011	Individually expressed HSV R1s counteracted caspase 8 activation by poly(I   C).	Poly I-C	68-78	caspase 8	Homo sapiens	44-53	
21697465-10	2011	TRIF silencing reduced poly(I   C)-triggered caspase 8 activation in mock- and ICP6Delta-infected cells, confirming that TRIF is involved in poly(I   C)-induced apoptosis.	Poly I-C	23-34	caspase 8	Homo sapiens	45-54	
21697465-10	2011	TRIF silencing reduced poly(I   C)-triggered caspase 8 activation in mock- and ICP6Delta-infected cells, confirming that TRIF is involved in poly(I   C)-induced apoptosis.	Poly I-C	141-152	caspase 8	Homo sapiens	45-54	
21646299-5	2011	Significant TLR3-mediated apoptosis was induced by polyinosinic-polycytidylic acid, a dsRNA analog, via caspase-8-dependent mechanisms.	Poly I-C	51-82	caspase 8	Homo sapiens	104-113	
21367858-4	2011	Poly(I-C) induced the activation of both caspases 8 and 9, indicating that TLR3 triggered the signaling of both the extrinsic and intrinsic apoptotic pathways.	Poly I-C	0-8	caspase 8	Homo sapiens	41-57	
20019748-6	2010	Significantly, sensitisation towards poly I:C-dependent caspase-8 activation and apoptosis in melanoma cells was also achieved by the synthetic Smac mimetic/inhibitor of apoptosis protein (IAP) antagonist, LBW242, or by specific downregulation of cIAP1 by siRNA.	Poly I-C	37-45	caspase 8	Homo sapiens	56-65