PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25381637-0	2015	Sphingosine 1-phosphate lyase inhibition by 2-acetyl-4-(tetrahydroxybutyl)imidazole (THI) under conditions of vitamin B6 deficiency.	2-acetyl-4(5)-tetrahydroxybutylimidazole	44-83	sphingosine-1-phosphate lyase 1	Homo sapiens	0-29	
25381637-0	2015	Sphingosine 1-phosphate lyase inhibition by 2-acetyl-4-(tetrahydroxybutyl)imidazole (THI) under conditions of vitamin B6 deficiency.	2-acetyl-4(5)-tetrahydroxybutylimidazole	85-88	sphingosine-1-phosphate lyase 1	Homo sapiens	0-29	
25381637-1	2015	Caramel food colorant 2-acetyl-4-(tetrahydroxybutyl)imidazole (THI) causes lymphopenia in animals through sphingosine 1-phosphate lyase (SPL) inhibition.	2-acetyl-4(5)-tetrahydroxybutylimidazole	22-61	sphingosine-1-phosphate lyase 1	Homo sapiens	106-135	
25381637-1	2015	Caramel food colorant 2-acetyl-4-(tetrahydroxybutyl)imidazole (THI) causes lymphopenia in animals through sphingosine 1-phosphate lyase (SPL) inhibition.	2-acetyl-4(5)-tetrahydroxybutylimidazole	22-61	sphingosine-1-phosphate lyase 1	Homo sapiens	137-140	
25381637-1	2015	Caramel food colorant 2-acetyl-4-(tetrahydroxybutyl)imidazole (THI) causes lymphopenia in animals through sphingosine 1-phosphate lyase (SPL) inhibition.	2-acetyl-4(5)-tetrahydroxybutylimidazole	63-66	sphingosine-1-phosphate lyase 1	Homo sapiens	106-135	
25381637-1	2015	Caramel food colorant 2-acetyl-4-(tetrahydroxybutyl)imidazole (THI) causes lymphopenia in animals through sphingosine 1-phosphate lyase (SPL) inhibition.	2-acetyl-4(5)-tetrahydroxybutylimidazole	63-66	sphingosine-1-phosphate lyase 1	Homo sapiens	137-140	
25381637-5	2015	By the use of VB6-deficient culture medium, we could regulate apo- (without PLP) and holo- (with PLP) SPL enzyme in cultured cells, resulting in the successful detection of SPL inhibition by THI.	2-acetyl-4(5)-tetrahydroxybutylimidazole	191-194	sphingosine-1-phosphate lyase 1	Homo sapiens	102-105	
25381637-5	2015	By the use of VB6-deficient culture medium, we could regulate apo- (without PLP) and holo- (with PLP) SPL enzyme in cultured cells, resulting in the successful detection of SPL inhibition by THI.	2-acetyl-4(5)-tetrahydroxybutylimidazole	191-194	sphingosine-1-phosphate lyase 1	Homo sapiens	173-176	
25381637-6	2015	Although the observed inhibitory effect was not as strong as that of 4-deoxypyridoxine (a VB6 analog SPL inhibitor), these findings may be useful for further understanding the mechanism of action of THI.	2-acetyl-4(5)-tetrahydroxybutylimidazole	199-202	sphingosine-1-phosphate lyase 1	Homo sapiens	101-104	
21090716-2	2010	Medicinal chemistry efforts targeting S1PL by direct in vivo evaluation of synthetic analogues of 2-acetyl-4(5)-(1(R),2(S),3(R),4-tetrahydroxybutyl)-imidazole (THI, 1) led to the discovery of 2 (LX2931) and 4 (LX2932).	2-acetyl-4(5)-tetrahydroxybutylimidazole	160-163	sphingosine-1-phosphate lyase 1	Homo sapiens	38-42