PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23251633-0 2012 Hexachlorophene is a potent KCNQ1/KCNE1 potassium channel activator which rescues LQTs mutants. Hexachlorophene 0-15 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 34-39 23251633-4 2012 In this study we report that hexachlorophene (HCP), the active component of the topical anti-infective prescription drug pHisoHex, is a KCNQ1/KCNE1 activator. Hexachlorophene 29-44 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 142-147 23251633-4 2012 In this study we report that hexachlorophene (HCP), the active component of the topical anti-infective prescription drug pHisoHex, is a KCNQ1/KCNE1 activator. Hexachlorophene 46-49 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 142-147 23251633-5 2012 HCP potently increases the current amplitude of KCNQ1/KCNE1 expressed by stabilizing the channel in an open state with an EC(50) of 4.61 +- 1.29 muM. Hexachlorophene 0-3 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 54-59 23251633-8 2012 Our results indicate HCP is a novel KCNQ1/KCNE1 activator and may be a useful tool compound for the development of LQTs therapeutics. Hexachlorophene 21-24 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 42-47