PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9486183-4 1998 In contrast, both MDL-72527 and DFMO inhibited the increase in putrescine level and DNA synthesis at 16.5 h. These findings suggest that putrescine produced from preexistent spermidine by SSAT is responsible for the initial DNA synthesis after mucosal injury induced by NaCl and that both SSAT and ODC are involved in formation of putrescine, which is required for subsequent DNA synthesis. Eflornithine 32-36 spermidine/spermine N1-acetyl transferase 1 Rattus norvegicus 188-192 25323967-12 2014 In addition, DFMO (0.5 mM) down regulated the expression of ODC, glucose-regulated protein 78 (GRP78), C/EBP homologous protein (CHOP), cleaved caspase-12, and Bax and up regulated the expression of SSAT and Bcl-2. Eflornithine 13-17 spermidine/spermine N1-acetyl transferase 1 Rattus norvegicus 199-203 9486183-4 1998 In contrast, both MDL-72527 and DFMO inhibited the increase in putrescine level and DNA synthesis at 16.5 h. These findings suggest that putrescine produced from preexistent spermidine by SSAT is responsible for the initial DNA synthesis after mucosal injury induced by NaCl and that both SSAT and ODC are involved in formation of putrescine, which is required for subsequent DNA synthesis. Eflornithine 32-36 spermidine/spermine N1-acetyl transferase 1 Rattus norvegicus 289-293 27074051-12 2016 DFMO down-regulated the expression of ODC, glucose-regulated protein 78 (GRP78), C/EBP homologous protein (CHOP), cleaved caspase-12, and Bax and up-regulated the expression of SSAT and Bcl-2. Eflornithine 0-4 spermidine/spermine N1-acetyl transferase 1 Rattus norvegicus 177-181 24824458-9 2014 Surprisingly, addition of DENSpm along with DFMO restored AZ1 induction by putrescine in polyamine-depleted cells suggesting that the increased SSAT activity in response to DENSpm converted SPM to SPD, leading to the expression of AZ1. Eflornithine 44-48 spermidine/spermine N1-acetyl transferase 1 Rattus norvegicus 144-148