PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16520895-11 2006 However, Bcl-2 is further enhanced following prolactin stimulation for 4 h and this enhancement is blocked by DFMO. Eflornithine 110-114 BCL2 apoptosis regulator Homo sapiens 9-14 16520895-12 2006 Bcl-2 has no effect on ODC activity and protein levels, but ODC upregulates Bcl-2, which is inhibited by DFMO. Eflornithine 105-109 BCL2 apoptosis regulator Homo sapiens 76-81 11776633-6 2000 In addition, transfection with antisense bcl-2 did not induce marked apoptosis whereas treatment of the transfectant with low concentration (0.2 mmol/L) of DFMO resulted in enhanced expression inhibition of bcl-2 protein, inhibition of cell growth and induction of apoptosis. Eflornithine 156-160 BCL2 apoptosis regulator Homo sapiens 207-212 22344475-12 2012 The ODC specific inhibitor, DFMO, altered the apoptotic effects of ROSC by increasing the generation of reactive oxygen species, decreasing the PA intracellular pool and modulating pro-apoptotic and anti-apoptotic Bcl-2 family members. Eflornithine 28-32 BCL2 apoptosis regulator Homo sapiens 214-219 34638596-7 2021 Additionally, significant changes in Bcl-2, Bcl-xL, Bax protein levels, activation of caspase-3, and cleavage of poly (ADP-ribose) polymerase were observed, indicating the apoptotic effects of DFMO. Eflornithine 193-197 BCL2 apoptosis regulator Homo sapiens 37-42