PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25582705-4 2015 In this study, the effects of PA on the transforming growth factor-beta1 (TGF-beta1)-mediated epithelial-mesenchymal transition (EMT) in A549 cells, on the apoptosis of human type I alveolar epithelial cells (AT I), on the proliferation of human lung fibroblasts (HLF-1) in vitro, and on bleomycin (BLM)-induced pulmonary fibrosis in vivo were investigated. Bleomycin 288-297 transforming growth factor beta 1 Homo sapiens 40-72 29377033-1 2017 While our previous studies suggest that limiting bleomycin-induced complement activation suppresses TGF-beta signaling, the specific hierarchical interactions between TGF-beta and complement in lung fibrosis are unclear. Bleomycin 49-58 transforming growth factor beta 1 Homo sapiens 100-108 27513632-0 2016 miR-221 targets HMGA2 to inhibit bleomycin-induced pulmonary fibrosis by regulating TGF-beta1/Smad3-induced EMT. Bleomycin 33-42 transforming growth factor beta 1 Homo sapiens 84-93 27471572-0 2016 Bleomycin (BLM) Induces Epithelial-to-Mesenchymal Transition in Cultured A549 Cells via the TGF-beta/Smad Signaling Pathway. Bleomycin 0-9 transforming growth factor beta 1 Homo sapiens 92-100 27471572-0 2016 Bleomycin (BLM) Induces Epithelial-to-Mesenchymal Transition in Cultured A549 Cells via the TGF-beta/Smad Signaling Pathway. Bleomycin 11-14 transforming growth factor beta 1 Homo sapiens 92-100 27144281-0 2016 MAP3K19 Is a Novel Regulator of TGF-beta Signaling That Impacts Bleomycin-Induced Lung Injury and Pulmonary Fibrosis. Bleomycin 64-73 transforming growth factor beta 1 Homo sapiens 32-40 29158503-10 2017 Our results demonstrates that KLF4 plays an important role in bleomycin-induced lung fibrosis through suppressing TGFbeta1-induced EMT. Bleomycin 62-71 transforming growth factor beta 1 Homo sapiens 114-122 27894300-9 2016 TGF-beta1 was also overexpressed in pleural lavage fluid and was produced by pleural cells following intravenous bleomycin. Bleomycin 113-122 transforming growth factor beta 1 Homo sapiens 0-9 26010495-6 2015 Bleomycin-induction resulted in significant elevation of matrix metalloproteinase (MMP)-2 and -9 expression, increased RNA and protein expression of transforming growth factor (TGF)-beta1, Smads and alpha-smooth muscle actin (alpha-SMA). Bleomycin 0-9 transforming growth factor beta 1 Homo sapiens 149-187 25547017-9 2015 Similar to human SSc, the same expression patterns of miR-130b, PPARgamma, and fibrosis-related genes were observed in the bleomycin-induced skin fibrosis model; TGF-beta induced the expression of miR-130b and fibrosis-related genes expression, but downregulated the expression of PPARgamma. Bleomycin 123-132 transforming growth factor beta 1 Homo sapiens 162-170 25848047-5 2015 Moreover, in vivo the bleomycin-induced down-regulation of peroxisomes was abrogated in transforming growth factor beta (TGF-beta) receptor II knockout mice indicating a role for TGF-beta signaling in the regulation of peroxisomes. Bleomycin 22-31 transforming growth factor beta 1 Homo sapiens 121-129 25582705-4 2015 In this study, the effects of PA on the transforming growth factor-beta1 (TGF-beta1)-mediated epithelial-mesenchymal transition (EMT) in A549 cells, on the apoptosis of human type I alveolar epithelial cells (AT I), on the proliferation of human lung fibroblasts (HLF-1) in vitro, and on bleomycin (BLM)-induced pulmonary fibrosis in vivo were investigated. Bleomycin 288-297 transforming growth factor beta 1 Homo sapiens 74-83 25582705-4 2015 In this study, the effects of PA on the transforming growth factor-beta1 (TGF-beta1)-mediated epithelial-mesenchymal transition (EMT) in A549 cells, on the apoptosis of human type I alveolar epithelial cells (AT I), on the proliferation of human lung fibroblasts (HLF-1) in vitro, and on bleomycin (BLM)-induced pulmonary fibrosis in vivo were investigated. Bleomycin 299-302 transforming growth factor beta 1 Homo sapiens 40-72 25582705-4 2015 In this study, the effects of PA on the transforming growth factor-beta1 (TGF-beta1)-mediated epithelial-mesenchymal transition (EMT) in A549 cells, on the apoptosis of human type I alveolar epithelial cells (AT I), on the proliferation of human lung fibroblasts (HLF-1) in vitro, and on bleomycin (BLM)-induced pulmonary fibrosis in vivo were investigated. Bleomycin 299-302 transforming growth factor beta 1 Homo sapiens 74-83 22095546-9 2012 A novel inhibitor of galectin-3, TD139, blocked TGF-beta-induced beta-catenin activation in vitro and in vivo and attenuated the late-stage progression of lung fibrosis after bleomycin. Bleomycin 175-184 transforming growth factor beta 1 Homo sapiens 48-56 25029475-6 2015 Significantly, pirfenidone attenuated the expression change of one (CTHRC1) translational gene marker in the bleomycin-induced lung fibrosis model, in transforming growth factor-beta1-treated primary human lung fibroblasts and transforming growth factor-beta1-treated human epithelial A549 cells. Bleomycin 109-118 transforming growth factor beta 1 Homo sapiens 227-259 25446881-9 2015 Over-expression of S1PL attenuated bleomycin-induced TGF-beta secretion and S1P mediated differentiation of human lung fibroblasts through regulation of autophagy. Bleomycin 35-44 transforming growth factor beta 1 Homo sapiens 53-61 25280005-12 2014 Interestingly, in a model of lung fibrosis induced by either bleomycin or silica, PDGF-D was down-regulated, which correlates with the production of TGFbeta and other fibrotic growth factors. Bleomycin 61-70 transforming growth factor beta 1 Homo sapiens 149-156 24655310-10 2014 Upregulation of the TGF-beta/CCN2 pathway was also detected in bleomycin-treated VM specimens. Bleomycin 63-72 transforming growth factor beta 1 Homo sapiens 20-28 22033267-7 2012 Intrapulmonary delivery of aerosolized siRNAs of TGF-beta1 with sequences common to humans and rodents significantly inhibited bleomycin-induced pulmonary fibrosis in the acute and chronic phases of the disease and in a dose-dependent manner. Bleomycin 127-136 transforming growth factor beta 1 Homo sapiens 49-58 24374669-8 2014 CONCLUSIONS: The bleomycin infusion model stimulates dermal fibroproliferation, creating reproducible murine scars that are comparable to human hypertrophic scars in terms of histological features, collagen content and organization, cellularity, the presence of myofibroblasts, and expression of transforming growth factor beta1. Bleomycin 17-26 transforming growth factor beta 1 Homo sapiens 296-328 24118261-0 2013 Bleomycin inhibits adipogenesis and accelerates fibrosis in the subcutaneous adipose layer through TGF-beta1. Bleomycin 0-9 transforming growth factor beta 1 Homo sapiens 99-108 24118261-4 2013 We found that bleomycin suppresses adipogenesis in adipose-derived stem cells (ASCs) and stimulates ASCs to express transforming growth factor beta1 (TGF-beta1), which suppresses adipogenesis and promotes fibrosis. Bleomycin 14-23 transforming growth factor beta 1 Homo sapiens 116-148 24118261-4 2013 We found that bleomycin suppresses adipogenesis in adipose-derived stem cells (ASCs) and stimulates ASCs to express transforming growth factor beta1 (TGF-beta1), which suppresses adipogenesis and promotes fibrosis. Bleomycin 14-23 transforming growth factor beta 1 Homo sapiens 150-159 24118261-6 2013 We concluded that in the skin affected by bleomycin-induced fibrosis, increased TGF-beta1 expression suppresses adipogenesis and promotes adipocyte fibrosis. Bleomycin 42-51 transforming growth factor beta 1 Homo sapiens 80-89 24327935-2 2013 We have recently described the molecular mechanisms whereby bleomycin can 1) promote endoplasmic reticulum stress, causing the immunogenic death of cancer cells and hence strengthening antitumor CD8+ T cell responses; and 2) induce the secretion of transforming growth factor beta (TGFbeta), which stimulates regulatory T cells. Bleomycin 60-69 transforming growth factor beta 1 Homo sapiens 249-280 24327935-2 2013 We have recently described the molecular mechanisms whereby bleomycin can 1) promote endoplasmic reticulum stress, causing the immunogenic death of cancer cells and hence strengthening antitumor CD8+ T cell responses; and 2) induce the secretion of transforming growth factor beta (TGFbeta), which stimulates regulatory T cells. Bleomycin 60-69 transforming growth factor beta 1 Homo sapiens 282-289 23259863-7 2012 Recently we have further shown that FGF10 signaling, a process that is necessary for distal lung morphogenesis, can also antagonize bleomycin-induced lung fibrosis in adult mice by a mechanism involving inhibition of active TGF beta ligand bioavailability. Bleomycin 132-141 transforming growth factor beta 1 Homo sapiens 224-232 20201077-13 2010 Inhibition of PDGF-B and TGFbeta pathways by treatment with imatinib restored the levels of miR-29a in vitro and in the bleomycin model in vivo. Bleomycin 120-129 transforming growth factor beta 1 Homo sapiens 25-32 22003091-8 2012 In addition, we analyzed the influence of transforming growth factor-beta (TGF-beta), a critical mediator of pulmonary fibrosis that is upregulated after bleomycin-induced lung injury, on tight junctions in vitro. Bleomycin 154-163 transforming growth factor beta 1 Homo sapiens 75-83 22003091-10 2012 These results suggest that bleomycin-induced lung injury causes pathogenic alterations in tight junctions and that such alterations seem to be induced by TGF-beta. Bleomycin 27-36 transforming growth factor beta 1 Homo sapiens 154-162 33671452-0 2021 Regorafenib-Attenuated, Bleomycin-Induced Pulmonary Fibrosis by Inhibiting the TGF-beta1 Signaling Pathway. Bleomycin 24-33 transforming growth factor beta 1 Homo sapiens 79-88 17916809-3 2008 OBJECTIVES: To analyze the expression of alpha(v)beta6 in human pulmonary fibrosis, and to functionally test the efficacy of therapeutic inhibition of alpha(v)beta6-mediated TGF-beta activation in murine bleomycin-induced pulmonary fibrosis. Bleomycin 204-213 transforming growth factor beta 1 Homo sapiens 174-182 18395486-8 2008 Also in the bleomycin model, CTGF, which is highly induced following TGFbeta stimulation, was attenuated with anti-JE/anti-MCP5 treatment. Bleomycin 12-21 transforming growth factor beta 1 Homo sapiens 69-76 16049324-4 2005 The majority of cells demonstrating TGF-beta activation and myofibroblast differentiation in bleomycin-induced lesions were Thy-1-negative. Bleomycin 93-102 transforming growth factor beta 1 Homo sapiens 36-44 10417748-0 1999 Perspective article: transforming growth factor-beta: crossroad of glucocorticoid and bleomycin regulation of collagen synthesis in lung fibroblasts. Bleomycin 86-95 transforming growth factor beta 1 Homo sapiens 21-52 10417748-3 1999 Both glucocorticoids and bleomycin have recently been shown to affect collagen synthesis in opposite directions, by utilizing a common pathway of involving transforming growth factor-beta activator protein binding to the transforming growth factor-beta element. Bleomycin 25-34 transforming growth factor beta 1 Homo sapiens 156-187 10417748-3 1999 Both glucocorticoids and bleomycin have recently been shown to affect collagen synthesis in opposite directions, by utilizing a common pathway of involving transforming growth factor-beta activator protein binding to the transforming growth factor-beta element. Bleomycin 25-34 transforming growth factor beta 1 Homo sapiens 221-252 10417748-4 1999 This article presents a mechanistic overview of collagen synthesis regulation by glucocorticoids and bleomycin through the transforming growth factor-beta pathway. Bleomycin 101-110 transforming growth factor beta 1 Homo sapiens 123-154 7541221-0 1995 Increased expression of transforming growth factor beta isoforms (beta 1, beta 2, beta 3) in bleomycin-induced pulmonary fibrosis. Bleomycin 93-102 transforming growth factor beta 1 Homo sapiens 24-55 7541221-6 1995 During the "inflammatory" phase (days 1 and 3) of bleomycin-induced injury there was an increase in the mRNA and protein expression of all three TGF-beta isoforms in the injured areas, most prominently in parenchymal cells and alveolar macrophages. Bleomycin 50-59 transforming growth factor beta 1 Homo sapiens 145-153 35021035-8 2022 MEASUREMENTS AND MAIN RESULTS: Bleomycin or ABT-510 increased lung TGF-beta1 activity and macrophage influx, caused pulmonary hypertension and led to alveolar and microvascular hypoplasia. Bleomycin 31-40 transforming growth factor beta 1 Homo sapiens 67-76 17387717-0 2007 Therapies for bleomycin induced lung fibrosis through regulation of TGF-beta1 induced collagen gene expression. Bleomycin 14-23 transforming growth factor beta 1 Homo sapiens 68-77 17387717-4 2007 Bleomycin (BM), a potent antineoplastic antibiotic increases TGF-beta1 transcription, TGF-beta1 gene expression, and TGF-beta protein. Bleomycin 0-9 transforming growth factor beta 1 Homo sapiens 61-70 17387717-4 2007 Bleomycin (BM), a potent antineoplastic antibiotic increases TGF-beta1 transcription, TGF-beta1 gene expression, and TGF-beta protein. Bleomycin 0-9 transforming growth factor beta 1 Homo sapiens 86-95 17387717-4 2007 Bleomycin (BM), a potent antineoplastic antibiotic increases TGF-beta1 transcription, TGF-beta1 gene expression, and TGF-beta protein. Bleomycin 0-9 transforming growth factor beta 1 Homo sapiens 61-69 17387717-4 2007 Bleomycin (BM), a potent antineoplastic antibiotic increases TGF-beta1 transcription, TGF-beta1 gene expression, and TGF-beta protein. Bleomycin 11-13 transforming growth factor beta 1 Homo sapiens 61-70 17387717-4 2007 Bleomycin (BM), a potent antineoplastic antibiotic increases TGF-beta1 transcription, TGF-beta1 gene expression, and TGF-beta protein. Bleomycin 11-13 transforming growth factor beta 1 Homo sapiens 86-95 17387717-4 2007 Bleomycin (BM), a potent antineoplastic antibiotic increases TGF-beta1 transcription, TGF-beta1 gene expression, and TGF-beta protein. Bleomycin 11-13 transforming growth factor beta 1 Homo sapiens 61-69 16187293-2 2006 Bleomycin acts through TGF-beta1. Bleomycin 0-9 transforming growth factor beta 1 Homo sapiens 23-32 16187293-3 2006 Bleomycin stimulates the COL1A1 promoter through the distal TGF-beta response element by intracellular and extracellular signaling. Bleomycin 0-9 transforming growth factor beta 1 Homo sapiens 60-68 16187293-6 2006 Bleomycin"s extracellular signaling results from the secretion of more latent TGF-beta produced by lung fibroblasts and cleaved to active TGF-beta extracellularly. Bleomycin 0-9 transforming growth factor beta 1 Homo sapiens 78-86 16187293-6 2006 Bleomycin"s extracellular signaling results from the secretion of more latent TGF-beta produced by lung fibroblasts and cleaved to active TGF-beta extracellularly. Bleomycin 0-9 transforming growth factor beta 1 Homo sapiens 138-146 16187293-7 2006 Since the TGF-beta genes are auto-induced in human embryonic IMR-90 lung fibroblasts, this study indicates an autocrine mechanism to maintain homeostasis in vivo for fibroblasts and other cell types, which produce TGF-beta1 to limit the fibrogenic response to TGF-beta1 and Bleomycin. Bleomycin 274-283 transforming growth factor beta 1 Homo sapiens 10-18 16187293-7 2006 Since the TGF-beta genes are auto-induced in human embryonic IMR-90 lung fibroblasts, this study indicates an autocrine mechanism to maintain homeostasis in vivo for fibroblasts and other cell types, which produce TGF-beta1 to limit the fibrogenic response to TGF-beta1 and Bleomycin. Bleomycin 274-283 transforming growth factor beta 1 Homo sapiens 214-223 12761881-0 2003 TGF-beta1-induced Smad 3 binding to the Smad 7 gene: knockout of Smad 7 gene transcription by sense phosphorothioate oligos, autoregulation, and effect on TGF-beta1 secretion: bleomycin acts through TGF-beta1. Bleomycin 176-185 transforming growth factor beta 1 Homo sapiens 0-9 12761881-1 2003 Bleomycin produces its fibrogenic effect, at least in part, by TGF-beta1 secretion. Bleomycin 0-9 transforming growth factor beta 1 Homo sapiens 63-72 12761881-2 2003 Treatment of IMR-90 human embryonic lung fibroblasts with bleomycin at 0.5 microg/ml results in a 1.6-fold increase of TGF-beta1 as determined by a specific ELISA assay for TGF-beta1 after acidification of the conditioned media. Bleomycin 58-67 transforming growth factor beta 1 Homo sapiens 119-128 12761881-2 2003 Treatment of IMR-90 human embryonic lung fibroblasts with bleomycin at 0.5 microg/ml results in a 1.6-fold increase of TGF-beta1 as determined by a specific ELISA assay for TGF-beta1 after acidification of the conditioned media. Bleomycin 58-67 transforming growth factor beta 1 Homo sapiens 173-182 12051713-0 2002 Regulation of Smad3 expression in bleomycin-induced pulmonary fibrosis: a negative feedback loop of TGF-beta signaling. Bleomycin 34-43 transforming growth factor beta 1 Homo sapiens 100-108 12051713-9 2002 These studies provide direct evidence for a differential regulation of Smad3 expression that is distinct from that of Smad2 during bleomycin-induced pulmonary fibrosis and suggest a ligand-induced negative feedback loop that modulates cellular TGF-beta signaling. Bleomycin 131-140 transforming growth factor beta 1 Homo sapiens 244-252 11238047-6 2001 Additionally, triptolide blocked bleomycin-induced increase in TGF-beta mRNA in cultured normal human lung fibroblasts. Bleomycin 33-42 transforming growth factor beta 1 Homo sapiens 63-71 11072666-2 2000 Models of experimental organ fibrosis such as bleomycin- or irradiation-induced lung fibrosis indicate that the continuous overexpression of major growth factors such as transforming growth factor beta 1 plays a major role in the tissue reorganization process and the modulation of the accompanying immune response. Bleomycin 46-55 transforming growth factor beta 1 Homo sapiens 170-203 10229865-13 1999 The concentrations of IL-8, G-CSF, monocyte chemoattractant protein-1, GM-CSF, and TGF-beta in the supernatant fluids significantly increased in response to bleomycin. Bleomycin 157-166 transforming growth factor beta 1 Homo sapiens 83-91 34068694-0 2021 Deglycosylated Azithromycin Attenuates Bleomycin-Induced Pulmonary Fibrosis via the TGF-beta1 Signaling Pathway. Bleomycin 39-48 transforming growth factor beta 1 Homo sapiens 84-93 33639908-7 2021 RESULTS: Here, we found that bleomycin induces the activation of the HIF-1alpha/TGFbeta1 signalling pathway and further enhances the migration and proliferation of fibroblasts through the epithelial mesenchymal transition (EMT). Bleomycin 29-38 transforming growth factor beta 1 Homo sapiens 80-88 33671452-8 2021 In conclusion, regorafenib attenuates bleomycin-induced pulmonary fibrosis by suppressing the TGF-beta1 signaling pathway. Bleomycin 38-47 transforming growth factor beta 1 Homo sapiens 94-103 33068010-0 2021 Bleomycin: a novel osteogenesis inhibitor of dental follicle cells via TGF-beta1/SMAD7/RUNX2 pathway. Bleomycin 0-9 transforming growth factor beta 1 Homo sapiens 71-80 31631444-5 2020 Based on the experimental observation, it was demonstrated that with TGF-beta as a central mediator of fibrosis progression, a cross-talk between epithelial-mesenchymal transition (EMT) and senescence upon bleomycin treatment occurs. Bleomycin 206-215 transforming growth factor beta 1 Homo sapiens 69-77 32649526-0 2020 Corrigendum: Follistatin-Like 1 Promotes Bleomycin-Induced Pulmonary Fibrosis Through the Transforming Growth Factor Beta 1/Mitogen-Activated Protein Kinase Signaling Pathway. Bleomycin 41-50 transforming growth factor beta 1 Homo sapiens 90-123 31173491-7 2019 Injection of bleomycin induced expression of pSmad3 and TGFbeta1 in the skin, which was inhibited by anti-CX3 CL1 mAb. Bleomycin 13-22 transforming growth factor beta 1 Homo sapiens 56-64 31589215-8 2019 Furthermore, we show that BMN consisting of HA and bleomycin can inhibit the proliferation of human hypertrophic scar fibroblasts (hHSFs) and the secretion of transforming growth factor-beta (TGF-beta1) in vitro. Bleomycin 51-60 transforming growth factor beta 1 Homo sapiens 192-201 31868203-3 2020 Here, we identified that the pulmonary fibrosis inducer bleomycin simultaneously increased the expression of bFGF and TGF-beta1 and inhibited epithelial-specific regulatory protein (ESRP1) expression in vivo and in vitro. Bleomycin 56-65 transforming growth factor beta 1 Homo sapiens 118-127 31868203-7 2020 Taken together, these findings suggest that bleomycin induced EMT through downregulating ESRP1 by simultaneously increasing bFGF and TGF-beta1 in pulmonary fibrosis. Bleomycin 44-53 transforming growth factor beta 1 Homo sapiens 133-142 31885648-0 2019 Kangfuxin Oral Liquid Attenuates Bleomycin-Induced Pulmonary Fibrosis via the TGF-beta1/Smad Pathway. Bleomycin 33-42 transforming growth factor beta 1 Homo sapiens 78-87 31331325-0 2019 Tenofovir alafenamide fumarate attenuates bleomycin-induced pulmonary fibrosis by upregulating the NS5ATP9 and TGF-beta1/Smad3 signaling pathway. Bleomycin 42-51 transforming growth factor beta 1 Homo sapiens 111-120 31556264-2 2019 microRNA-155 (miR-155), the expression of which has been related to bleomycin-induced idiopathic pulmonary fibrosis, has been involved in TGF-beta induced epithelial-mesenchymal transition. Bleomycin 68-77 transforming growth factor beta 1 Homo sapiens 138-146 29722566-0 2018 Inhibition of Raf1 ameliorates bleomycin-induced pulmonary fibrosis through attenuation of TGF-beta1 signaling. Bleomycin 31-40 transforming growth factor beta 1 Homo sapiens 91-100