PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8424954-6 1993 However, in the presence of 3.5 mg bleomycin/ml medium wild-type cells have a slight growth advantage compared to blh1 mutant cells. Bleomycin 35-44 bleomycin hydrolase Saccharomyces cerevisiae S288C 114-118 14558142-7 2003 Moreover, the interaction between IMP2 and GAL6/BLH1, a recently isolated gene involved in the regulation of GAL genes that shares with Imp2 the ability to protect cells from the glycopeptide bleomycin, was also analysed. Bleomycin 192-201 bleomycin hydrolase Saccharomyces cerevisiae S288C 43-47 14558142-7 2003 Moreover, the interaction between IMP2 and GAL6/BLH1, a recently isolated gene involved in the regulation of GAL genes that shares with Imp2 the ability to protect cells from the glycopeptide bleomycin, was also analysed. Bleomycin 192-201 bleomycin hydrolase Saccharomyces cerevisiae S288C 48-52 9374524-1 1997 Bleomycin hydrolase is a cysteine peptidase discovered through its ability to detoxify the anti-cancer glycopeptide, bleomycin. Bleomycin 117-126 bleomycin hydrolase Saccharomyces cerevisiae S288C 0-19 8718865-1 1996 The bleomycin-inactivating enzyme, bleomycin hydrolase, is believed to be involved in tumor resistance to the anticancer drug bleomycin. Bleomycin 4-13 bleomycin hydrolase Saccharomyces cerevisiae S288C 35-54 8718865-7 1996 However, the ability of bleomycin hydrolase to hydrolyze and inactivate bleomycin was totally abolished in all three mutants, suggesting that the cysteine thiol and histidine imidazole are critical for hydrolyzing bleomycin. Bleomycin 72-81 bleomycin hydrolase Saccharomyces cerevisiae S288C 24-43 7638617-1 1995 Bleomycin hydrolase is a cysteine protease that hydrolyzes the anticancer drug bleomycin. Bleomycin 79-88 bleomycin hydrolase Saccharomyces cerevisiae S288C 0-19 8463237-12 1993 However, blh1 mutants show hypersensitivity to bleomycin, indicating that bleomycin hydrolase is able to inactivate bleomycin in vivo and to protect cells from bleomycin-induced toxicity. Bleomycin 47-56 bleomycin hydrolase Saccharomyces cerevisiae S288C 9-13 8463237-12 1993 However, blh1 mutants show hypersensitivity to bleomycin, indicating that bleomycin hydrolase is able to inactivate bleomycin in vivo and to protect cells from bleomycin-induced toxicity. Bleomycin 47-56 bleomycin hydrolase Saccharomyces cerevisiae S288C 74-93 8463237-12 1993 However, blh1 mutants show hypersensitivity to bleomycin, indicating that bleomycin hydrolase is able to inactivate bleomycin in vivo and to protect cells from bleomycin-induced toxicity. Bleomycin 74-83 bleomycin hydrolase Saccharomyces cerevisiae S288C 9-13 8463237-12 1993 However, blh1 mutants show hypersensitivity to bleomycin, indicating that bleomycin hydrolase is able to inactivate bleomycin in vivo and to protect cells from bleomycin-induced toxicity. Bleomycin 74-83 bleomycin hydrolase Saccharomyces cerevisiae S288C 9-13 17007609-1 2007 Bleomycin hydrolase (BH) is a hexameric papain family cysteine protease which is involved in preparing peptides for antigen presentation and has been implicated in tumour cell resistance to bleomycin chemotherapy. Bleomycin 190-199 bleomycin hydrolase Saccharomyces cerevisiae S288C 0-19 12555812-3 2002 It has been postulated that bleomycin hydrolase, a protease encoded by the BLH1 gene in humans, may account for tumor resistance to bleomycin. Bleomycin 28-37 bleomycin hydrolase Saccharomyces cerevisiae S288C 75-79 12555812-4 2002 In support of such a notion, earlier studies showed that exogenous expression of yeast Blh1 in human cells can enhance resistance to bleomycin. Bleomycin 133-142 bleomycin hydrolase Saccharomyces cerevisiae S288C 87-91 12555812-5 2002 Here we show that (i) yeast blh1delta mutants are not sensitive to bleomycin, (ii) bleomycin-hypersensitive yeast mutants were no more sensitive to this agent upon deletion of the BLH1/LAP3/GAL6 gene, and (iii) overproduction of Blhl in either the parent or bleomycin-hypersensitive mutants did not confer additional resistance to these strains. Bleomycin 83-92 bleomycin hydrolase Saccharomyces cerevisiae S288C 180-184 12555812-5 2002 Here we show that (i) yeast blh1delta mutants are not sensitive to bleomycin, (ii) bleomycin-hypersensitive yeast mutants were no more sensitive to this agent upon deletion of the BLH1/LAP3/GAL6 gene, and (iii) overproduction of Blhl in either the parent or bleomycin-hypersensitive mutants did not confer additional resistance to these strains. Bleomycin 83-92 bleomycin hydrolase Saccharomyces cerevisiae S288C 185-189 12555812-5 2002 Here we show that (i) yeast blh1delta mutants are not sensitive to bleomycin, (ii) bleomycin-hypersensitive yeast mutants were no more sensitive to this agent upon deletion of the BLH1/LAP3/GAL6 gene, and (iii) overproduction of Blhl in either the parent or bleomycin-hypersensitive mutants did not confer additional resistance to these strains. Bleomycin 83-92 bleomycin hydrolase Saccharomyces cerevisiae S288C 190-194 12555812-5 2002 Here we show that (i) yeast blh1delta mutants are not sensitive to bleomycin, (ii) bleomycin-hypersensitive yeast mutants were no more sensitive to this agent upon deletion of the BLH1/LAP3/GAL6 gene, and (iii) overproduction of Blhl in either the parent or bleomycin-hypersensitive mutants did not confer additional resistance to these strains. Bleomycin 83-92 bleomycin hydrolase Saccharomyces cerevisiae S288C 180-184 12555812-5 2002 Here we show that (i) yeast blh1delta mutants are not sensitive to bleomycin, (ii) bleomycin-hypersensitive yeast mutants were no more sensitive to this agent upon deletion of the BLH1/LAP3/GAL6 gene, and (iii) overproduction of Blhl in either the parent or bleomycin-hypersensitive mutants did not confer additional resistance to these strains. Bleomycin 83-92 bleomycin hydrolase Saccharomyces cerevisiae S288C 185-189 12555812-5 2002 Here we show that (i) yeast blh1delta mutants are not sensitive to bleomycin, (ii) bleomycin-hypersensitive yeast mutants were no more sensitive to this agent upon deletion of the BLH1/LAP3/GAL6 gene, and (iii) overproduction of Blhl in either the parent or bleomycin-hypersensitive mutants did not confer additional resistance to these strains. Bleomycin 83-92 bleomycin hydrolase Saccharomyces cerevisiae S288C 190-194 9584198-1 1998 Yeast bleomycin hydrolase, Gal6p, is a cysteine peptidase that detoxifies the anticancer drug bleomycin. Bleomycin 6-15 bleomycin hydrolase Saccharomyces cerevisiae S288C 27-32 9584198-6 1998 Variant Gal6 proteins that fail to bind nucleic acid also exhibit reduced ability to protect cells from bleomycin toxicity, suggesting that the nucleic acid binding activity of Gal6p is important in bleomycin detoxification and may be involved in its normal biological functions. Bleomycin 104-113 bleomycin hydrolase Saccharomyces cerevisiae S288C 8-12 9584198-6 1998 Variant Gal6 proteins that fail to bind nucleic acid also exhibit reduced ability to protect cells from bleomycin toxicity, suggesting that the nucleic acid binding activity of Gal6p is important in bleomycin detoxification and may be involved in its normal biological functions. Bleomycin 104-113 bleomycin hydrolase Saccharomyces cerevisiae S288C 177-182 9584198-6 1998 Variant Gal6 proteins that fail to bind nucleic acid also exhibit reduced ability to protect cells from bleomycin toxicity, suggesting that the nucleic acid binding activity of Gal6p is important in bleomycin detoxification and may be involved in its normal biological functions. Bleomycin 199-208 bleomycin hydrolase Saccharomyces cerevisiae S288C 8-12 9584198-6 1998 Variant Gal6 proteins that fail to bind nucleic acid also exhibit reduced ability to protect cells from bleomycin toxicity, suggesting that the nucleic acid binding activity of Gal6p is important in bleomycin detoxification and may be involved in its normal biological functions. Bleomycin 199-208 bleomycin hydrolase Saccharomyces cerevisiae S288C 177-182 7476893-0 1995 Yeast cysteine proteinase gene ycp1 induces resistance to bleomycin in mammalian cells. Bleomycin 58-67 bleomycin hydrolase Saccharomyces cerevisiae S288C 31-35