PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20510675-5	2010	AS605240 also inhibited augmented expression of TNF-alpha and IL-1beta induced by bleomycin instillation.	Bleomycin	82-91	interleukin 1 beta	Rattus norvegicus	62-70	
25672255-7	2015	In addition, BLM-induced increased expression of tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, cyclooxygenase-2, prostaglandin E2, malondialdehyde, inducible nitric oxide synthase and nitric oxide in rats, which was also suppressed by Tan IIA injection.	Bleomycin	13-16	interleukin 1 beta	Rattus norvegicus	78-100	
26977316-8	2016	TNF-alpha, IL-1beta, and MDA levels and hydroxyproline content significantly increased (p < 0.01) and GPx and SOD activities significantly decreased in bleomycin group (p < 0.01).	Bleomycin	155-164	interleukin 1 beta	Rattus norvegicus	11-19	
18462759-9	2008	Immunohistochemical studies revealed that DAS reduced the bleomycin-induced activation of inducible nitric oxide synthase (iNOS) and nuclear factor kappa-B (NF-kappaB) and decreased the augmented levels of the early inflammatory cytokines, tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), in the lung tissues.	Bleomycin	58-67	interleukin 1 beta	Rattus norvegicus	285-302	
18462759-9	2008	Immunohistochemical studies revealed that DAS reduced the bleomycin-induced activation of inducible nitric oxide synthase (iNOS) and nuclear factor kappa-B (NF-kappaB) and decreased the augmented levels of the early inflammatory cytokines, tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), in the lung tissues.	Bleomycin	58-67	interleukin 1 beta	Rattus norvegicus	304-312	
31611754-9	2019	Hesperidin significantly inhibited BLM-induced down-regulated lung Nrf2 and HO-1 as well as up-regulated TNF-alpha, IL-1beta, IL-6, collagen-1, TGF-beta, and Smad-3 mRNA expressions.	Bleomycin	35-38	interleukin 1 beta	Rattus norvegicus	116-124	
1376744-11	1992	Synergism with IL-1 beta was also noted with the fibrogenic agent bleomycin.	Bleomycin	66-75	interleukin 1 beta	Rattus norvegicus	15-24	
17992263-6	2007	Exogenous rIL-1beta recapitulated a high degree of bleomycin-induced lung pathology, and specific blockade of IL-1R1 by IL-1 receptor antagonist dramatically reduced bleomycin-induced inflammation.	Bleomycin	51-60	interleukin 1 beta	Rattus norvegicus	10-19	
16879498-9	2006	5 Circulating plasma levels of TNF-alpha/IL-1beta were augmented in bleomycin-exposed rats compared with controls.	Bleomycin	68-77	interleukin 1 beta	Rattus norvegicus	41-49	
31611754-12	2019	Hesperidin alleviates BLM-induced IPF via inhibition of TGF-beta1/Smad3/AMPK and IkappaBalpha/NF-kappaB pathways which in turn ameliorate the modulation of oxido-inflammatory markers (Nrf2 and HO-1) and pro-inflammatory markers (TNF-alpha, IL-1beta, and IL-6) to reduce collagen deposition during pulmonary fibrosis.	Bleomycin	22-25	interleukin 1 beta	Rattus norvegicus	240-248	
29923060-6	2019	RESULTS: After 2 weeks, bleomycin significantly increased the pressure at the airway opening (PAO), a functional parameter related to fibrosis-induced lung stiffness, and induced diffuse lung interstitium fibrosis, with upregulation of inflammation (IL1beta, MCP1) and tissue remodeling (COL1A1, COL3A1, ET1, MMP7, PDGFa, alphaSMA, SNAI1) markers.	Bleomycin	24-33	interleukin 1 beta	Rattus norvegicus	250-257