PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17135359-5 2007 When compared with bleomycin-treated GITR+/+ mice, bleomycin-treated GITR-/- mice exhibited a reduced degree of i) lung infiltration with polymorphonuclear neutrophils (MPO activity); ii) edema formation; iii) histological evidence of lung injury; iv) TNF-alpha and interleukin (IL)-1beta production; v) nitrotyrosine formation; and vi) NF-kappaB activation. Bleomycin 51-60 interleukin 1 beta Mus musculus 266-288 27895584-10 2016 In addition, iPS cell administration remarkably suppressed BLM-induced up-regulation of pulmonary inflammatory mediators, including tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, inducible nitric oxide synthase, nitric oxide, cyclooxygenase-2 and prostaglandin E2. Bleomycin 59-62 interleukin 1 beta Mus musculus 161-183 10612569-1 1999 OBJECTIVE: We previously observed increased expression of interleukin-1beta, platelet-derived growth factor-A, and insulin-like growth factor-I in bronchoalveolar lavage (BAL) cells during the development of pulmonary fibrosis after an intraperitoneal administration of bleomycin in mice. Bleomycin 270-279 interleukin 1 beta Mus musculus 58-75 7694632-7 1993 Analysis of (C57BL/6JxBALB/cBy)F1 hybrids, which are shown in this report to be sensitive to bleomycin-induced fibrosis, revealed a high IL-1 beta mRNA level, similar to that in the resistant parent. Bleomycin 93-102 interleukin 1 beta Mus musculus 137-146 28662409-6 2017 The results showed an alleviated pulmonary inflammation and fibrosis in myeloid differentiation primary response gene 88 (MyD88)-deficient mice treated with bleomycin (BLM), accompanied with a reduced TGF-beta signaling and production of pro-fibrotic cytokines, including TNF-alpha, IL-1beta. Bleomycin 157-166 interleukin 1 beta Mus musculus 283-291 27307019-6 2016 In parallel, there was a significant upregulation of procollagen alpha1(I), alpha-SMA and TGF-beta transcripts in HOCl animals, whereas IL-1beta and MMP-13 mRNA levels were significantly increased in bleomycin-treated mice. Bleomycin 200-209 interleukin 1 beta Mus musculus 136-144 16317386-4 2005 An increase of immunoreactivity to poly-ADP-ribose, TNF-alpha, and IL-1 beta, as well as a significant loss of body weight and mortality was observed in the lung of bleomycin-treated PPAR-alpha WT mice. Bleomycin 165-174 interleukin 1 beta Mus musculus 67-76 31873099-6 2019 Overexpression of Cav-1 suppressed bleomycin- or silica-induced activation of caspase-1 and maturation of pro-IL-1beta to secrete cleaved IL-1beta both in mouse lungs and in primary type I cells. Bleomycin 35-44 interleukin 1 beta Mus musculus 138-146 29675024-4 2018 In this study, we first analyzed a bleomycin-induced mouse model, which showed that higher expression of IL-1beta, but not IL-18, was correlated to pulmonary cell infiltration and fibrosis. Bleomycin 35-44 interleukin 1 beta Mus musculus 105-113 27306439-15 2016 This study demonstrated that FD, attenuates BLM-induced pulmonary inflammation and fibrosis in mice via inhibiting the activation of NALP3 inflammasome and the IL-1beta/IL-1R1/MyD88/ NF-kappaB pathway. Bleomycin 44-47 interleukin 1 beta Mus musculus 160-168 24885478-5 2014 Compared with littermate wild-type (WT) mice, TGF-beta1(wt) Tg mice had over twofold-higher levels of latent TGF-beta1 in both plasma and lung tissue, and were protected from bleomycin-induced pulmonary inflammation, such as up-regulation of IL-1beta, TNF-alpha, and macrophage chemotactic protein-1, and infiltration of CD3(+) T cells and F4/80(+) macrophages. Bleomycin 175-184 interleukin 1 beta Mus musculus 242-250 25441030-7 2015 We further demonstrate that bleomycin-induced BAFF expression and lung fibrosis were IL-1beta and IL-17A dependent. Bleomycin 28-37 interleukin 1 beta Mus musculus 85-93 25551570-8 2014 Instillation of both bleomycin and Ad vectors increased expression levels of TNFalpha and IL-1beta but not IL-10. Bleomycin 21-30 interleukin 1 beta Mus musculus 90-98 22466555-4 2012 Treatment with HSYA also alleviated bleomycin-induced increase of mRNA level of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and transforming growth factor (TGF)-beta1 in lung homogenates. Bleomycin 36-45 interleukin 1 beta Mus musculus 115-137 19265174-3 2009 In the present study, we examined the role of the proinflammatory cytokines IL-18 and IL-1beta in the mechanism of bleomycin-induced lung injury. Bleomycin 115-124 interleukin 1 beta Mus musculus 86-94 19265174-7 2009 Intravenous administration of bleomycin induced the expression of IL-1beta and IL-18 in the serum and lungs of wild-type C57BL/6 mice. Bleomycin 30-39 interleukin 1 beta Mus musculus 66-74 18598692-7 2008 Both pirfenidone and prednisolone suppressed the increase in lung interleukin (IL)-1beta, IL-6, IL-12p40 and monocyte chemoattractant protein (MCP)-1 levels induced by bleomycin. Bleomycin 168-177 interleukin 1 beta Mus musculus 66-88 17992263-7 2007 Finally, we found that lung IL-1beta production and inflammation in response to bleomycin required ASC, an inflammasome adaptor molecule. Bleomycin 80-89 interleukin 1 beta Mus musculus 28-36 17880775-4 2007 An increase in immunoreactivity to nitrotyrosine, iNOS, TNF-alpha and IL-1beta was also observed in the lungs of BLM-treated mice. Bleomycin 113-116 interleukin 1 beta Mus musculus 70-78 17880775-5 2007 In contrast, administration of BLM-treated mice with TDZD-8 (1 mg/kg daily) significantly reduced (I) the degree of lung injury, (II) the increase in staining (immunohistochemistry) for myeloperoxidase (MPO), nitrotyrosine, iNOS, TNF-alpha and IL-1beta and (III) the degree of apoptosis, as evaluated by Bax and Bcl-2 immunoreactivity and TUNEL staining. Bleomycin 31-34 interleukin 1 beta Mus musculus 244-252 24886817-6 2014 Bleomycin exposure induced expression of MDA, IKKalpha, phosphorylated IKKalpha (p-IKKalpha), NF-kappaB P65, TNF-alpha and IL-1beta, and reduced I-kappaB expression in mice lung tissue or in BALF. Bleomycin 0-9 interleukin 1 beta Mus musculus 123-131 23619613-5 2013 Processing of polysialylated NCAM was reproduced in a mouse model by bleomycin administration leading to an activation of the inflammasome and secretion of interleukin (IL)-1beta. Bleomycin 69-78 interleukin 1 beta Mus musculus 156-178 19118846-8 2009 The BAL fluid concentrations of interleukin-1beta, interleukin-6, RANTES, and high mobility group box 1 were significantly increased by pneumonectomy and enhanced by the additional administration of bleomycin. Bleomycin 199-208 interleukin 1 beta Mus musculus 32-49