PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29675024-4	2018	In this study, we first analyzed a bleomycin-induced mouse model, which showed that higher expression of IL-1beta, but not IL-18, was correlated to pulmonary cell infiltration and fibrosis.	Bleomycin	35-44	interleukin 1 beta	Mus musculus	105-113	
31873099-6	2019	Overexpression of Cav-1 suppressed bleomycin- or silica-induced activation of caspase-1 and maturation of pro-IL-1beta to secrete cleaved IL-1beta both in mouse lungs and in primary type I cells.	Bleomycin	35-44	interleukin 1 beta	Mus musculus	138-146	
28662409-6	2017	The results showed an alleviated pulmonary inflammation and fibrosis in myeloid differentiation primary response gene 88 (MyD88)-deficient mice treated with bleomycin (BLM), accompanied with a reduced TGF-beta signaling and production of pro-fibrotic cytokines, including TNF-alpha, IL-1beta.	Bleomycin	157-166	interleukin 1 beta	Mus musculus	283-291	
27895584-10	2016	In addition, iPS cell administration remarkably suppressed BLM-induced up-regulation of pulmonary inflammatory mediators, including tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, inducible nitric oxide synthase, nitric oxide, cyclooxygenase-2 and prostaglandin E2.	Bleomycin	59-62	interleukin 1 beta	Mus musculus	161-183	
27306439-15	2016	This study demonstrated that FD, attenuates BLM-induced pulmonary inflammation and fibrosis in mice via inhibiting the activation of NALP3 inflammasome and the IL-1beta/IL-1R1/MyD88/ NF-kappaB pathway.	Bleomycin	44-47	interleukin 1 beta	Mus musculus	160-168	
27307019-6	2016	In parallel, there was a significant upregulation of procollagen alpha1(I), alpha-SMA and TGF-beta transcripts in HOCl animals, whereas IL-1beta and MMP-13 mRNA levels were significantly increased in bleomycin-treated mice.	Bleomycin	200-209	interleukin 1 beta	Mus musculus	136-144	
25551570-8	2014	Instillation of both bleomycin and Ad vectors increased expression levels of TNFalpha and IL-1beta but not IL-10.	Bleomycin	21-30	interleukin 1 beta	Mus musculus	90-98	
25441030-7	2015	We further demonstrate that bleomycin-induced BAFF expression and lung fibrosis were IL-1beta and IL-17A dependent.	Bleomycin	28-37	interleukin 1 beta	Mus musculus	85-93	
24886817-6	2014	Bleomycin exposure induced expression of MDA, IKKalpha, phosphorylated IKKalpha (p-IKKalpha), NF-kappaB P65, TNF-alpha and IL-1beta, and reduced I-kappaB expression in mice lung tissue or in BALF.	Bleomycin	0-9	interleukin 1 beta	Mus musculus	123-131	
24885478-5	2014	Compared with littermate wild-type (WT) mice, TGF-beta1(wt) Tg mice had over twofold-higher levels of latent TGF-beta1 in both plasma and lung tissue, and were protected from bleomycin-induced pulmonary inflammation, such as up-regulation of IL-1beta, TNF-alpha, and macrophage chemotactic protein-1, and infiltration of CD3(+) T cells and F4/80(+) macrophages.	Bleomycin	175-184	interleukin 1 beta	Mus musculus	242-250	
23619613-5	2013	Processing of polysialylated NCAM was reproduced in a mouse model by bleomycin administration leading to an activation of the inflammasome and secretion of interleukin (IL)-1beta.	Bleomycin	69-78	interleukin 1 beta	Mus musculus	156-178	
22466555-4	2012	Treatment with HSYA also alleviated bleomycin-induced increase of mRNA level of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and transforming growth factor (TGF)-beta1 in lung homogenates.	Bleomycin	36-45	interleukin 1 beta	Mus musculus	115-137	
19265174-3	2009	In the present study, we examined the role of the proinflammatory cytokines IL-18 and IL-1beta in the mechanism of bleomycin-induced lung injury.	Bleomycin	115-124	interleukin 1 beta	Mus musculus	86-94	
19265174-7	2009	Intravenous administration of bleomycin induced the expression of IL-1beta and IL-18 in the serum and lungs of wild-type C57BL/6 mice.	Bleomycin	30-39	interleukin 1 beta	Mus musculus	66-74	
19118846-8	2009	The BAL fluid concentrations of interleukin-1beta, interleukin-6, RANTES, and high mobility group box 1 were significantly increased by pneumonectomy and enhanced by the additional administration of bleomycin.	Bleomycin	199-208	interleukin 1 beta	Mus musculus	32-49	
18598692-7	2008	Both pirfenidone and prednisolone suppressed the increase in lung interleukin (IL)-1beta, IL-6, IL-12p40 and monocyte chemoattractant protein (MCP)-1 levels induced by bleomycin.	Bleomycin	168-177	interleukin 1 beta	Mus musculus	66-88	
17135359-5	2007	When compared with bleomycin-treated GITR+/+ mice, bleomycin-treated GITR-/- mice exhibited a reduced degree of i) lung infiltration with polymorphonuclear neutrophils (MPO activity); ii) edema formation; iii) histological evidence of lung injury; iv) TNF-alpha and interleukin (IL)-1beta production; v) nitrotyrosine formation; and vi) NF-kappaB activation.	Bleomycin	51-60	interleukin 1 beta	Mus musculus	266-288	
17992263-7	2007	Finally, we found that lung IL-1beta production and inflammation in response to bleomycin required ASC, an inflammasome adaptor molecule.	Bleomycin	80-89	interleukin 1 beta	Mus musculus	28-36	
17880775-4	2007	An increase in immunoreactivity to nitrotyrosine, iNOS, TNF-alpha and IL-1beta was also observed in the lungs of BLM-treated mice.	Bleomycin	113-116	interleukin 1 beta	Mus musculus	70-78	
17880775-5	2007	In contrast, administration of BLM-treated mice with TDZD-8 (1 mg/kg daily) significantly reduced (I) the degree of lung injury, (II) the increase in staining (immunohistochemistry) for myeloperoxidase (MPO), nitrotyrosine, iNOS, TNF-alpha and IL-1beta and (III) the degree of apoptosis, as evaluated by Bax and Bcl-2 immunoreactivity and TUNEL staining.	Bleomycin	31-34	interleukin 1 beta	Mus musculus	244-252	
10612569-1	1999	OBJECTIVE: We previously observed increased expression of interleukin-1beta, platelet-derived growth factor-A, and insulin-like growth factor-I in bronchoalveolar lavage (BAL) cells during the development of pulmonary fibrosis after an intraperitoneal administration of bleomycin in mice.	Bleomycin	270-279	interleukin 1 beta	Mus musculus	58-75	
16317386-4	2005	An increase of immunoreactivity to poly-ADP-ribose, TNF-alpha, and IL-1 beta, as well as a significant loss of body weight and mortality was observed in the lung of bleomycin-treated PPAR-alpha WT mice.	Bleomycin	165-174	interleukin 1 beta	Mus musculus	67-76	
7694632-7	1993	Analysis of (C57BL/6JxBALB/cBy)F1 hybrids, which are shown in this report to be sensitive to bleomycin-induced fibrosis, revealed a high IL-1 beta mRNA level, similar to that in the resistant parent.	Bleomycin	93-102	interleukin 1 beta	Mus musculus	137-146