PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23258232-10 2013 Bleomycin-treated Pirb(-/-) mice displayed increased lung histopathology and an increased expression of collagen and of the IL-4-associated profibrogenic markers Relm-alpha, MMP-12, TIMP-1, and osteopontin, which were localized to alveolar macrophages. Bleomycin 0-9 interleukin 4 Mus musculus 124-128 15564778-6 2004 RESULTS: RT-PCR showed that both IL-4 and IL-13 mRNA levels in skin lesions were increased and peaked after 4 weeks of bleomycin treatment. Bleomycin 119-128 interleukin 4 Mus musculus 33-37 18467694-4 2008 Bleomycin-treated wild-type mice exhibited dermal and lung fibrosis, hyper-gamma-globulinemia, autoantibody production, and enhanced serum and skin expression of various cytokines, including fibrogenic interleukin-4, interleukin-6, and transforming growth factor-beta1, all of which were inhibited by CD19 deficiency. Bleomycin 0-9 interleukin 4 Mus musculus 202-215 12574379-3 2003 Lethal pulmonary injury after bleomycin treatment was higher in IL-4(-/-) vs IL-4(+/+) mice. Bleomycin 30-39 interleukin 4 Mus musculus 77-81 12928422-7 2003 Thus, this study demonstrates that IL-4- and/or IL-13-binding cells are required for the maintenance of pulmonary fibrosis induced by bleomycin and highlights the importance of further investigation of antifibrotic therapeutics that target these cells during pulmonary fibrosis. Bleomycin 134-143 interleukin 4 Mus musculus 35-39 12928422-3 2003 This led us to investigate whether the specific targeting of resident lung cells responsive to IL-4 and IL-13 exerted a therapeutic effect in an experimental model of IIP, namely the bleomycin-induced model of pulmonary fibrosis. Bleomycin 183-192 interleukin 4 Mus musculus 95-99 12928422-4 2003 IL-4, IL-13, and their corresponding receptor subunits, IL-4Ralpha, IL-13Ralpha1, and IL-13Ralpha2, were maximally expressed at the mRNA and protein levels in whole lung samples on day 21 or 28 after an intratracheal bleomycin challenge. Bleomycin 217-226 interleukin 4 Mus musculus 0-4 12574379-3 2003 Lethal pulmonary injury after bleomycin treatment was higher in IL-4(-/-) vs IL-4(+/+) mice. Bleomycin 30-39 interleukin 4 Mus musculus 64-68 12376365-0 2002 Bleomycin-induced lung fibrosis in IL-4-overexpressing and knockout mice. Bleomycin 0-9 interleukin 4 Mus musculus 35-39 12376365-5 2002 Comparing Bleo- to Sal-treated controls within each group of mice showed increases in all lung fibrosis parameters in IL-4 KO and WT, but not in any of the parameters in IL-4 TG mice. Bleomycin 10-14 interleukin 4 Mus musculus 118-122 12376365-6 2002 The severity of Bleo-induced fibrotic response was decreased in overexpressed IL-4 TG compared with IL-4 KO mice. Bleomycin 16-20 interleukin 4 Mus musculus 78-82 12376365-6 2002 The severity of Bleo-induced fibrotic response was decreased in overexpressed IL-4 TG compared with IL-4 KO mice. Bleomycin 16-20 interleukin 4 Mus musculus 100-104 33144678-0 2021 IL-24 deficiency protects mice against bleomycin-induced pulmonary fibrosis by repressing IL-4-induced M2 program in macrophages. Bleomycin 39-48 interleukin 4 Mus musculus 90-94 34719405-8 2021 When the mRNA levels of pro-inflammatory cytokines were examined 7 days after bleomycin administration, interleukin (IL)-6, IL-4 and IL-13 were significantly lower in the BH group than in the BA group. Bleomycin 78-87 interleukin 4 Mus musculus 124-128 11554783-0 2001 Lung interleukin-4 gene expression in a murine model of bleomycin-induced pulmonary fibrosis. Bleomycin 56-65 interleukin 4 Mus musculus 5-18 11554783-2 2001 To investigate the potential role of this cytokine, lung IL-4 expression was examined in a murine model of bleomycin-induced pulmonary fibrosis. Bleomycin 107-116 interleukin 4 Mus musculus 57-61 11554783-6 2001 Both in-situ hybridization and immunohistochemistry showed low or undetectable IL-4 expression in control lungs and in injured lungs before day 3 after bleomycin injection. Bleomycin 152-161 interleukin 4 Mus musculus 79-83 9341282-8 1997 Expression of IL-4 was high in the bleomycin group, and was not inhibited in the glucocorticoid group. Bleomycin 35-44 interleukin 4 Mus musculus 14-18 32272967-10 2020 Furthermore, the blockade of IL-4 signaling by IL-4Ralpha neutralizing antibodies attenuated the progression of fibrosis and the production of alpha2AP and HMGB1 in the bleomycin-induced mice. Bleomycin 169-178 interleukin 4 Mus musculus 29-33 33402751-0 2021 Correction: IL-24 deficiency protects mice against bleomycin-induced pulmonary fibrosis by repressing IL-4-induced M2 program in macrophages. Bleomycin 51-60 interleukin 4 Mus musculus 102-106 29782549-7 2018 Bleomycin administration stimulated the mRNA expression of the profibrotic cytokines IL-13 and IL-4 and the M2 markers including arginase 1, Fizz1/Retnla, Ccl17 and Ccl24 in cells collected from broncho-alveolar lavage fluids (BALF), and S1pr2 deletion markedly diminished the stimulated expression of these genes. Bleomycin 0-9 interleukin 4 Mus musculus 95-99