PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19520917-0 2010 Phosphatidylinositol-3-kinase/akt regulates bleomycin-induced fibroblast proliferation and collagen production. Bleomycin 44-53 AKT serine/threonine kinase 1 Homo sapiens 30-33 21302298-0 2011 TGFbeta- and bleomycin-induced extracellular matrix synthesis is mediated through Akt and mammalian target of rapamycin (mTOR). Bleomycin 13-22 AKT serine/threonine kinase 1 Homo sapiens 82-85 21302298-3 2011 In the current study, we investigated the importance of Akt1 in TGFbeta- and bleomycin-induced synthesis and secretion of ECM proteins by fibroblasts. Bleomycin 77-86 AKT serine/threonine kinase 1 Homo sapiens 56-60 21302298-5 2011 Treatment with TGFbeta and bleomycin also resulted in increased phosphorylation of Akt, mammalian target of rapamycin (mTOR) and their downstream signaling partners, p70S6 Kinase, Ribosomal S6 protein and 4E-BP1, resulting in the activation of this pathway. Bleomycin 27-36 AKT serine/threonine kinase 1 Homo sapiens 83-86 19520917-3 2010 Exposure of lung fibroblasts to bleomycin, a known inducer of fibrosis, resulted in rapid activation of PI3K/Akt and a parallel increase in fibroblast proliferation and collagen production, characteristics of lung fibrosis. Bleomycin 32-41 AKT serine/threonine kinase 1 Homo sapiens 109-112 17507800-8 2007 Also, cotransfection of constitutive active AKT plasmid with LMP-1 siRNA plasmid abrogates sensitivity of C666-1 to bleomycin and cisplatin. Bleomycin 116-125 AKT serine/threonine kinase 1 Homo sapiens 44-47 19520917-5 2010 Inhibition of this phosphorylation by PI3K inhibitors or by dominant-negative Akt (T308A/S473A) expression abrogated the effects of bleomycin on fibroblast proliferation and collagen production, suggesting the role of PI3K/Akt in the fibrogenic process. Bleomycin 132-141 AKT serine/threonine kinase 1 Homo sapiens 78-81 19520917-5 2010 Inhibition of this phosphorylation by PI3K inhibitors or by dominant-negative Akt (T308A/S473A) expression abrogated the effects of bleomycin on fibroblast proliferation and collagen production, suggesting the role of PI3K/Akt in the fibrogenic process. Bleomycin 132-141 AKT serine/threonine kinase 1 Homo sapiens 223-226 19520917-6 2010 Activation of PI3K/Akt by bleomycin also led to transcriptional activation and protein expression of hypoxia-inducible factor-1alpha (HIF-1alpha) and vascular endothelial growth factor, which contributed to the fibroproliferative and collagen-inducing effects of bleomycin. Bleomycin 26-35 AKT serine/threonine kinase 1 Homo sapiens 19-22 19520917-6 2010 Activation of PI3K/Akt by bleomycin also led to transcriptional activation and protein expression of hypoxia-inducible factor-1alpha (HIF-1alpha) and vascular endothelial growth factor, which contributed to the fibroproliferative and collagen-inducing effects of bleomycin. Bleomycin 263-272 AKT serine/threonine kinase 1 Homo sapiens 19-22 19520917-8 2010 Inhibition of ROS generation by antioxidant enzymes, catalase and superoxide dismutase mimetic MnTBAP, abrogated the fibrogenic effects of bleomycin as well as its induction of PI3K/Akt and HIF-1alpha activation. Bleomycin 139-148 AKT serine/threonine kinase 1 Homo sapiens 182-185 32550106-10 2020 Besides, phosphorylated SMAD2, phosphorylated SMAD3, phosphorylated Akt and phosphorylated ERK1/2 were all significantly increased after bleomycin treatment and decreased to normal levels after metformin intervention. Bleomycin 137-146 AKT serine/threonine kinase 1 Homo sapiens 68-71 31527305-8 2019 Bleomycin induced AEC senescence was reversed by Akt2 knockdown and the pharmacological inhibitors (LY294002 and MK2206) of the Akt pathway. Bleomycin 0-9 AKT serine/threonine kinase 1 Homo sapiens 49-52 28343070-0 2017 The activation of Akt/mTOR pathway by bleomycin in Epithelial-to-mesenchymal transition of human submandibular gland cells: A treatment mechanism of bleomycin for mucoceles of the salivary glands. Bleomycin 38-47 AKT serine/threonine kinase 1 Homo sapiens 18-21 28343070-0 2017 The activation of Akt/mTOR pathway by bleomycin in Epithelial-to-mesenchymal transition of human submandibular gland cells: A treatment mechanism of bleomycin for mucoceles of the salivary glands. Bleomycin 149-158 AKT serine/threonine kinase 1 Homo sapiens 18-21 26425798-4 2016 Ingenuity Pathway Analysis of proteins modulated in response to bleomycin treatment identified PI3K/Akt and Wnt signaling as the most significant profibrotic pathways. Bleomycin 64-73 AKT serine/threonine kinase 1 Homo sapiens 100-103 32436415-7 2020 PTEN expression was decreased and key downstream molecules in the phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway were gradually activated following bleomycin treatment. Bleomycin 183-192 AKT serine/threonine kinase 1 Homo sapiens 99-102 32436415-10 2020 CONCLUSIONS: Downregulation of PTEN mediates bleomycin-induced premature senescence in lung cancer cells by suppressing autophagy via the PI3K/Akt/mTOR pathway. Bleomycin 45-54 AKT serine/threonine kinase 1 Homo sapiens 143-146 31753588-0 2020 CXCL16/CXCR6 axis promotes bleomycin-induced fibrotic process in MRC-5 cells via the PI3K/AKT/FOXO3a pathway. Bleomycin 27-36 AKT serine/threonine kinase 1 Homo sapiens 90-93 31868203-5 2020 Notably, we determined that bFGF activates PI3K/Akt signaling, and treatment with the PI3K/Akt inhibitor LY294002 inhibited bleomycin-induced cell morphology changes and EMT. Bleomycin 124-133 AKT serine/threonine kinase 1 Homo sapiens 91-94 29808357-0 2018 IL-17A suppresses and curcumin up-regulates Akt expression upon bleomycin exposure. Bleomycin 64-73 AKT serine/threonine kinase 1 Homo sapiens 44-47 29808357-1 2018 Pro-inflammatory cytokine IL-17A modulates the expression of Akt in bleomycin (BLM) administered alveolar basal epithelial cells, the mechanism behind which remains unclear. Bleomycin 68-77 AKT serine/threonine kinase 1 Homo sapiens 61-64 29808357-1 2018 Pro-inflammatory cytokine IL-17A modulates the expression of Akt in bleomycin (BLM) administered alveolar basal epithelial cells, the mechanism behind which remains unclear. Bleomycin 79-82 AKT serine/threonine kinase 1 Homo sapiens 61-64 29079731-0 2017 Involvement of ER stress, PI3K/AKT activation, and lung fibroblast proliferation in bleomycin-induced pulmonary fibrosis. Bleomycin 84-93 AKT serine/threonine kinase 1 Homo sapiens 31-34 29079731-8 2017 PI3K/AKT acts upstream of ER stress to affect lung fibroblast proliferation, resulting in bleomycin-induced pulmonary fibrosis. Bleomycin 90-99 AKT serine/threonine kinase 1 Homo sapiens 5-8 25919965-4 2015 Bleomycin-induced nitric oxide (NO) was observed to be the key upstream regulator of VEGF via the PI3k/Akt pathway. Bleomycin 0-9 AKT serine/threonine kinase 1 Homo sapiens 103-106