PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31750010-7 2019 Lastly, upon bleomycin challenge, Myr-Akt mice showed enhanced collagen deposition, increased F4/80+ and CD45+ cells, reduced autophagy genes Beclin-1, Lc3a, and Lc3b expression, and a shorter life-span than WT littermates. Bleomycin 13-22 thymoma viral proto-oncogene 1 Mus musculus 38-41 31704290-0 2019 Tanshinone IIA ameliorates the bleomycin-induced endothelial-to-mesenchymal transition via the Akt/mTOR/p70S6K pathway in a murine model of systemic sclerosis. Bleomycin 31-40 thymoma viral proto-oncogene 1 Mus musculus 95-98 31704290-8 2019 Furthermore, mechanistically, the activation of the Akt/mTOR/p70S6K pathway was found to be involved in bleomycin-treated SSc mouse model, which was alleviated by Tan IIA. Bleomycin 104-113 thymoma viral proto-oncogene 1 Mus musculus 52-55 32115350-0 2020 Corrigendum to "Tanshinone IIA ameliorates the bleomycin-induced endothelial-to-mesenchymal transition via the Akt/mTOR/p70S6K pathway in a murine model of systemic sclerosis" [Int. Bleomycin 47-56 thymoma viral proto-oncogene 1 Mus musculus 111-114 32006666-7 2020 RESULTS: bleomycin succeeded to induce pulmonary fibrosis in mice, with increased TG2 expression, EMT and Akt activation. Bleomycin 9-18 thymoma viral proto-oncogene 1 Mus musculus 106-109 30928090-0 2019 S-allyl-l-cysteine attenuates bleomycin-induced pulmonary fibrosis and inflammation via AKT/NF-kappaB signaling pathway in mice. Bleomycin 30-39 thymoma viral proto-oncogene 1 Mus musculus 88-91 28234968-0 2017 Trichostatin A attenuates ventilation-augmented epithelial-mesenchymal transition in mice with bleomycin-induced acute lung injury by suppressing the Akt pathway. Bleomycin 95-104 thymoma viral proto-oncogene 1 Mus musculus 150-153 28743499-6 2017 Furthermore, bleomycin upregulated EphA2, EphrinA1, PI3K 110gamma, Akt, IL-6 and TNF-alpha. Bleomycin 13-22 thymoma viral proto-oncogene 1 Mus musculus 67-70 28743499-7 2017 However, administration of ATRA attenuated the upregulation of EphA2-EphrinA1 and PI3K-Akt after bleomycin instillation, and decreased pulmonary fibrosis. Bleomycin 97-106 thymoma viral proto-oncogene 1 Mus musculus 87-90 28743499-9 2017 Collectively, these data suggest that ATRA attenuates bleomycin-induced pulmonary fibrosis by regulating EphA2-EphrinA1 and PI3K-Akt signaling. Bleomycin 54-63 thymoma viral proto-oncogene 1 Mus musculus 129-132 28263743-0 2017 Deficiency of Psgl-1 accelerates bleomycin (BLM)-induced lung fibrosis and inflammation in mice through activating PI3K/AKT. Bleomycin 33-42 thymoma viral proto-oncogene 1 Mus musculus 120-123 28263743-0 2017 Deficiency of Psgl-1 accelerates bleomycin (BLM)-induced lung fibrosis and inflammation in mice through activating PI3K/AKT. Bleomycin 44-47 thymoma viral proto-oncogene 1 Mus musculus 120-123 28263743-4 2017 In the present study, we attempted to clarify the AKT activation induced by Psgl-1 knockout in mice with bleomycin (BLM)-induced pulmonary fibrosis. Bleomycin 105-114 thymoma viral proto-oncogene 1 Mus musculus 50-53 28263743-4 2017 In the present study, we attempted to clarify the AKT activation induced by Psgl-1 knockout in mice with bleomycin (BLM)-induced pulmonary fibrosis. Bleomycin 116-119 thymoma viral proto-oncogene 1 Mus musculus 50-53 29345193-9 2018 In addition, we found that treatment with ketanserin activated pulmonary MAPK and Akt signaling in mice exposed to bleomycin. Bleomycin 115-124 thymoma viral proto-oncogene 1 Mus musculus 82-85 29185215-0 2018 Nickle(II) ions exacerbate bleomycin-induced pulmonary inflammation and fibrosis by activating the ROS/Akt signaling pathway. Bleomycin 27-36 thymoma viral proto-oncogene 1 Mus musculus 103-106 28678919-8 2017 Up-regulation of Cox-2 and inactivation of PI3K/AKT/mTOR were found in bleomycin-pretreated cells, while these abnormal regulations were partially abolished by miR-142-3p overexpression and NS-398. Bleomycin 71-80 thymoma viral proto-oncogene 1 Mus musculus 48-51 28678919-9 2017 In conclusion, this study demonstrated that miR-142-3p overexpression protected bleomycin-induced injury in lung epithelial MLE-12 cells, possibly via regulating Cox-2 expression and PI3K/AKT/mTOR signaling pathway. Bleomycin 80-89 thymoma viral proto-oncogene 1 Mus musculus 188-191 28234968-3 2017 We hypothesized that trichostatin A (TSA), a HDAC inhibitor, can reduce MV-augmented bleomycin-induced EMT by inhibiting the HDAC4 and Akt pathways. Bleomycin 85-94 thymoma viral proto-oncogene 1 Mus musculus 135-138 15681821-4 2005 In a murine model of intratracheal bleomycin-induced lung fibrosis, regions of active fibrogenesis demonstrate elevated expression of PKB/Akt and FAK phosphorylation in vivo, effects that are attenuated in mice receiving daily intraperitoneal injections of AG1879 (bleomycin-AG1879) versus a chemically inactive analog (bleomycin-control). Bleomycin 35-44 thymoma viral proto-oncogene 1 Mus musculus 134-141 26895395-11 2016 CONCLUSIONS: AT accelerates the resolution of lung inflammation and fibrosis in a model of bleomycin-induced lung fibrosis partly via attenuation of 5-HT/Akt signaling. Bleomycin 91-100 thymoma viral proto-oncogene 1 Mus musculus 154-157 26828700-9 2016 Mice with miR-155 knockout or topical antagomir-155 treatment showed inhibited Wnt/beta-catenin and Akt signaling in skin upon bleomycin challenge. Bleomycin 127-136 thymoma viral proto-oncogene 1 Mus musculus 100-103 18713087-7 2008 Expression of phosphorylated Akt and Erk, which are thought to mediate the survival signalling pathway induced by EPO, tended to be increased in lung tissues from mice treated with EPO compared with those from mice treated with saline after bleomycin instillation. Bleomycin 241-250 thymoma viral proto-oncogene 1 Mus musculus 29-32 26520185-11 2016 In addition, BLM-induced phosphorylation of pulmonary p38 MAPK and protein kinase B (Akt) was inhibited by calcitriol. Bleomycin 13-16 thymoma viral proto-oncogene 1 Mus musculus 85-88 22198238-11 2012 Our findings also revealed that bleomycin inhibited Akt activation and suppressed bcl-2. Bleomycin 32-41 thymoma viral proto-oncogene 1 Mus musculus 52-55 17485510-7 2007 TGF-beta(1) and bleomycin also activated phosphatidylinositol 3-kinase (PI3K) and protein kinase B (PKB)/AKT via SEMA 7A-dependent mechanisms, and PKB/AKT inhibition diminished TGF-beta(1)-induced fibrosis. Bleomycin 16-25 thymoma viral proto-oncogene 1 Mus musculus 100-103 17485510-7 2007 TGF-beta(1) and bleomycin also activated phosphatidylinositol 3-kinase (PI3K) and protein kinase B (PKB)/AKT via SEMA 7A-dependent mechanisms, and PKB/AKT inhibition diminished TGF-beta(1)-induced fibrosis. Bleomycin 16-25 thymoma viral proto-oncogene 1 Mus musculus 105-108 17485510-7 2007 TGF-beta(1) and bleomycin also activated phosphatidylinositol 3-kinase (PI3K) and protein kinase B (PKB)/AKT via SEMA 7A-dependent mechanisms, and PKB/AKT inhibition diminished TGF-beta(1)-induced fibrosis. Bleomycin 16-25 thymoma viral proto-oncogene 1 Mus musculus 147-150 17485510-7 2007 TGF-beta(1) and bleomycin also activated phosphatidylinositol 3-kinase (PI3K) and protein kinase B (PKB)/AKT via SEMA 7A-dependent mechanisms, and PKB/AKT inhibition diminished TGF-beta(1)-induced fibrosis. Bleomycin 16-25 thymoma viral proto-oncogene 1 Mus musculus 151-154 15681821-4 2005 In a murine model of intratracheal bleomycin-induced lung fibrosis, regions of active fibrogenesis demonstrate elevated expression of PKB/Akt and FAK phosphorylation in vivo, effects that are attenuated in mice receiving daily intraperitoneal injections of AG1879 (bleomycin-AG1879) versus a chemically inactive analog (bleomycin-control). Bleomycin 265-274 thymoma viral proto-oncogene 1 Mus musculus 134-141 15681821-4 2005 In a murine model of intratracheal bleomycin-induced lung fibrosis, regions of active fibrogenesis demonstrate elevated expression of PKB/Akt and FAK phosphorylation in vivo, effects that are attenuated in mice receiving daily intraperitoneal injections of AG1879 (bleomycin-AG1879) versus a chemically inactive analog (bleomycin-control). Bleomycin 265-274 thymoma viral proto-oncogene 1 Mus musculus 134-141 15681821-5 2005 PKB/Akt and FAK phosphorylation are elevated in fibroblasts isolated from lungs of bleomycin-injured mice, effects that are inhibited in bleomycin-AG1879 mice. Bleomycin 83-92 thymoma viral proto-oncogene 1 Mus musculus 0-7 15681821-5 2005 PKB/Akt and FAK phosphorylation are elevated in fibroblasts isolated from lungs of bleomycin-injured mice, effects that are inhibited in bleomycin-AG1879 mice. Bleomycin 137-146 thymoma viral proto-oncogene 1 Mus musculus 0-7 34266726-10 2021 Moreover, Akt/mTOR/p70S6K phosphorylation was involved in EndoMT and BMP-7 suppressed TGF-beta- or bleomycin-induced theses phosphorylation in HUVECs or SSc mouse model. Bleomycin 99-108 thymoma viral proto-oncogene 1 Mus musculus 10-13