PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25771975-10 2015 Consistent transcriptional down-regulation of the stress response factors tested (i.e. BiP, mtHsp60, Hsp70) occurred in the direct effect indicating that bleomycin might induce an arrest of transcription correlated with decreased survival. Bleomycin 154-163 heat shock protein 1B Mus musculus 101-106 30543447-9 2019 Hsp70-knockout mice subjected to an inhalational bleomycin model of pulmonary fibrosis demonstrated accelerated fibrosis versus wild-type control animals. Bleomycin 49-58 heat shock protein 1B Mus musculus 0-5 22096546-3 2011 We recently reported that expression of heat shock protein 70 (HSP70) protects against bleomycin-induced pulmonary fibrosis, an animal model of pulmonary fibrosis. Bleomycin 87-96 heat shock protein 1B Mus musculus 40-61 22096546-3 2011 We recently reported that expression of heat shock protein 70 (HSP70) protects against bleomycin-induced pulmonary fibrosis, an animal model of pulmonary fibrosis. Bleomycin 87-96 heat shock protein 1B Mus musculus 63-68 22096546-10 2011 Furthermore, oral co-administration of geranylgeranylacetone (GGA), an inducer of HSP70, suppressed gefitinib-induced exacerbation of bleomycin-induced pulmonary fibrosis. Bleomycin 134-143 heat shock protein 1B Mus musculus 82-87 22096546-11 2011 Taken together, these findings suggest that gefitinib-induced exacerbation of bleomycin-induced pulmonary fibrosis is mediated by suppression of pulmonary expression of HSP70 and that an inducer of HSP70 expression, such as GGA, may be therapeutically beneficial for the treatment of gefitinib-induced pulmonary fibrosis. Bleomycin 78-87 heat shock protein 1B Mus musculus 169-174 20513440-0 2010 Heat shock protein 70 protects against bleomycin-induced pulmonary fibrosis in mice. Bleomycin 39-48 heat shock protein 1B Mus musculus 0-21 20513440-4 2010 In this study, we examined the effect of expression of HSP70 on bleomycin-induced pulmonary fibrosis in mice, a tentative animal model of IPF. Bleomycin 64-73 heat shock protein 1B Mus musculus 55-60 20513440-5 2010 Bleomycin-induced pulmonary injury and inflammatory response were ameliorated in transgenic mice overexpressing HSP70 compared to wild-type mice, even though bleomycin-induced pulmonary fibrosis and dysfunction were also suppressed in the transgenic mice. Bleomycin 0-9 heat shock protein 1B Mus musculus 112-117 20513440-9 2010 These results suggest that HSP70 plays a protective role against bleomycin-induced pulmonary injury, inflammation, fibrosis and dysfunction through cytoprotective effects and by inhibiting the production of TGF-beta1, TGF-beta1-dependent EMT of epithelial cells and expression of pro-inflammatory cytokines. Bleomycin 65-74 heat shock protein 1B Mus musculus 27-32