PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19893044-6 2009 Bleomycin-treated CD103(-/-) mice had persistent neutrophilic inflammation, increased fibrosis, and increased mortality compared with wild-type mice, a phenotype that was partially recapitulated in bleomycin/nFMLP-treated Mmp7(-/-) mice. Bleomycin 0-9 integrin alpha E, epithelial-associated Mus musculus 18-23 19893044-6 2009 Bleomycin-treated CD103(-/-) mice had persistent neutrophilic inflammation, increased fibrosis, and increased mortality compared with wild-type mice, a phenotype that was partially recapitulated in bleomycin/nFMLP-treated Mmp7(-/-) mice. Bleomycin 198-207 integrin alpha E, epithelial-associated Mus musculus 18-23 34478832-9 2022 Additionally, LDLR (1.0 Gy) significantly reduced bleomycin-induced increases in interstitial macrophages, CD103+ dendritic cells and neutrophil-DC hybrids. Bleomycin 50-59 integrin alpha E, epithelial-associated Mus musculus 107-112 34478832-13 2022 Mechanistically, LDLR at 1.0 Gy significantly suppressed bleomycin-induced accumulation of pulmonary interstitial macrophages, CD103+ dendritic cells and neutrophil-DC hybrids. Bleomycin 57-66 integrin alpha E, epithelial-associated Mus musculus 127-132 31959382-3 2020 OBJECTIVE: We investigated the impact of CD103 loss on bleomycin-induced skin fibrosis because CD103 is a critical molecule determining DC phenotypes. Bleomycin 55-64 integrin alpha E, epithelial-associated Mus musculus 41-46 31959382-4 2020 METHODS: Bleomycin-induced skin fibrosis was generated with Cd103-/- mice. Bleomycin 9-18 integrin alpha E, epithelial-associated Mus musculus 60-65 31959382-7 2020 RESULTS: CD103 loss decreased bleomycin-induced dermal thickness and collagen contents, along with TGF-beta1 and CTGF suppression. Bleomycin 30-39 integrin alpha E, epithelial-associated Mus musculus 9-14 31959382-8 2020 Treg proportion was increased, while Th1/Th2/Th17 cell proportions were decreased in the skin of bleomycin-treated Cd103-/- mice. Bleomycin 97-106 integrin alpha E, epithelial-associated Mus musculus 115-120 31959382-9 2020 Bleomycin injection enhanced CD11b-CD103- DC proportion in wild-type mice, which was further augmented in Cd103-/- mice. Bleomycin 0-9 integrin alpha E, epithelial-associated Mus musculus 35-40 31959382-9 2020 Bleomycin injection enhanced CD11b-CD103- DC proportion in wild-type mice, which was further augmented in Cd103-/- mice. Bleomycin 0-9 integrin alpha E, epithelial-associated Mus musculus 106-111 31959382-10 2020 Importantly, RALDH1/ALDH1A1 enzyme oxidizing retinaldehyde to retinoic acid, an inducer of Tregs, was preferentially expressed by CD11b-CD103- DCs and its expression levels were elevated in bleomycin-injected skin lesions, to a greater extent in Cd103-/- mice than in wild-type mice. Bleomycin 190-199 integrin alpha E, epithelial-associated Mus musculus 136-141 31959382-10 2020 Importantly, RALDH1/ALDH1A1 enzyme oxidizing retinaldehyde to retinoic acid, an inducer of Tregs, was preferentially expressed by CD11b-CD103- DCs and its expression levels were elevated in bleomycin-injected skin lesions, to a greater extent in Cd103-/- mice than in wild-type mice. Bleomycin 190-199 integrin alpha E, epithelial-associated Mus musculus 246-251