PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33662577-6 2021 CCN2 deletion significantly reduced pulmonary interstitial scarring and fibrosis following bleomycin-instillation, as assessed by fibrotic scores (wildtype bleomycin 3.733 +- 0.2667 vs CCN2 knockout (KO) bleomycin 4.917 +- 0.3436, p < 0.05) and micro-CT. Bleomycin 91-100 cellular communication network factor 2 Mus musculus 0-4 33662577-6 2021 CCN2 deletion significantly reduced pulmonary interstitial scarring and fibrosis following bleomycin-instillation, as assessed by fibrotic scores (wildtype bleomycin 3.733 +- 0.2667 vs CCN2 knockout (KO) bleomycin 4.917 +- 0.3436, p < 0.05) and micro-CT. Bleomycin 156-165 cellular communication network factor 2 Mus musculus 0-4 33662577-6 2021 CCN2 deletion significantly reduced pulmonary interstitial scarring and fibrosis following bleomycin-instillation, as assessed by fibrotic scores (wildtype bleomycin 3.733 +- 0.2667 vs CCN2 knockout (KO) bleomycin 4.917 +- 0.3436, p < 0.05) and micro-CT. Bleomycin 156-165 cellular communication network factor 2 Mus musculus 0-4 26817844-7 2016 Intratracheal or intravenous delivery two or three times of amphiregulin or connective tissue growth factor SAMiRNAs significantly reduced the bleomycin- or TGF-beta-stimulated collagen accumulation in the lung and substantially restored the lung function of TGF-beta transgenic mice. Bleomycin 143-152 cellular communication network factor 2 Mus musculus 76-107 31848318-6 2019 In a mouse model of bleomycin-induced lung fibrosis, Lonidamine reduced the expression of genes encoding profibrotic markers (collagenIotaalpha1, EDA-fibronectin, alpha smooth muscle actin, and connective tissue growth factor) and stabilized or improved lung function as assessed by measurement of peripheral blood oxygenation. Bleomycin 20-29 cellular communication network factor 2 Mus musculus 194-225 27435108-8 2017 Additionally, connective tissue growth factor (CTGF) mRNA expression was increased in fibrocytes treated with periostin whereas CTGF and lysl oxidase (LOX) mRNA expression was low in bleomycin-treated periostin-/- fibrocytes. Bleomycin 183-192 cellular communication network factor 2 Mus musculus 14-45 27435108-8 2017 Additionally, connective tissue growth factor (CTGF) mRNA expression was increased in fibrocytes treated with periostin whereas CTGF and lysl oxidase (LOX) mRNA expression was low in bleomycin-treated periostin-/- fibrocytes. Bleomycin 183-192 cellular communication network factor 2 Mus musculus 128-132 24508728-8 2014 CTGF reporter mice demonstrated increased CTGF promoter activity by lung epithelial cells acutely after bleomycin in vivo. Bleomycin 104-113 cellular communication network factor 2 Mus musculus 0-4 24508728-8 2014 CTGF reporter mice demonstrated increased CTGF promoter activity by lung epithelial cells acutely after bleomycin in vivo. Bleomycin 104-113 cellular communication network factor 2 Mus musculus 42-46 24508728-9 2014 Furthermore, mice with lung epithelial cell-specific deletion of CTGF had an attenuated fibrotic response to bleomycin. Bleomycin 109-118 cellular communication network factor 2 Mus musculus 65-69 24574231-6 2014 CCN2-conditional knockout mice in which CCN2 was deleted from Sox2-expressing cells exhibited resistance to bleomycin-induced skin fibrosis. Bleomycin 108-117 cellular communication network factor 2 Mus musculus 0-4 24574231-6 2014 CCN2-conditional knockout mice in which CCN2 was deleted from Sox2-expressing cells exhibited resistance to bleomycin-induced skin fibrosis. Bleomycin 108-117 cellular communication network factor 2 Mus musculus 40-44 24574231-7 2014 Collectively, these results indicate that CCN2 is required for the recruitment of progenitor cells and that CCN2-expressing progenitor cells are essential for bleomycin-induced skin fibrosis. Bleomycin 159-168 cellular communication network factor 2 Mus musculus 108-112 20936632-0 2011 CCN2 is required for bleomycin-induced skin fibrosis in mice. Bleomycin 21-30 cellular communication network factor 2 Mus musculus 0-4 22833167-7 2012 Leukocyte infiltration and the expression of TGFbeta and CTGF messenger RNA in bleomycin-injected skin were significantly reduced in IL-17A-deficient mice compared with wild-type (WT) mice. Bleomycin 79-88 cellular communication network factor 2 Mus musculus 57-61 20581099-8 2011 In response to bleomycin treatment, measures of fibrosis and inflammation, along with CTGF and collagen I mRNA concentrations, were increased in TSP-1-deficient mice compared with WT mice. Bleomycin 15-24 cellular communication network factor 2 Mus musculus 86-90 21265950-0 2011 A novel single-chain-Fv antibody against connective tissue growth factor attenuates bleomycin-induced pulmonary fibrosis in mice. Bleomycin 84-93 cellular communication network factor 2 Mus musculus 41-72 21265950-3 2011 In the present study, the protective effect of anti-CTGF scFv against bleomycin (BL)-induced pulmonary fibrosis was investigated in mice. Bleomycin 70-79 cellular communication network factor 2 Mus musculus 52-56 21265950-3 2011 In the present study, the protective effect of anti-CTGF scFv against bleomycin (BL)-induced pulmonary fibrosis was investigated in mice. Bleomycin 81-83 cellular communication network factor 2 Mus musculus 52-56 20936632-3 2011 The aim of this study was to assess whether adult mice bearing a smooth muscle cell/fibroblast-specific deletion of CCN2 are resistant to bleomycin-induced skin scleroderma. Bleomycin 138-147 cellular communication network factor 2 Mus musculus 116-120 20936632-8 2011 RESULTS: The loss of CCN2 resulted in resistance to bleomycin-induced skin fibrosis. Bleomycin 52-61 cellular communication network factor 2 Mus musculus 21-25 20936632-11 2011 Collectively, these results indicate that CCN2 is essential for bleomycin-induced skin fibrosis, likely due to a defect in myofibroblast recruitment. Bleomycin 64-73 cellular communication network factor 2 Mus musculus 42-46 19916059-0 2010 Connective tissue growth factor is induced in bleomycin-induced skin scleroderma. Bleomycin 46-55 cellular communication network factor 2 Mus musculus 0-31 19916059-4 2010 In this report, we use an antibody recognizing CCN2 to assess the cell types in mouse dermis which express CCN2 in the bleomycin model of skin scleroderma. Bleomycin 119-128 cellular communication network factor 2 Mus musculus 107-111 19916059-7 2010 However, upon exposure to bleomycin, CCN2 was observed in the dermis. Bleomycin 26-35 cellular communication network factor 2 Mus musculus 37-41 19916059-11 2010 Moreover, CCN2-expressing pericytes significantly contribute to the appearance of myofibroblasts in bleomycin-induced skin scleroderma. Bleomycin 100-109 cellular communication network factor 2 Mus musculus 10-14 15862142-0 2005 [A preliminary study of CTGF in bleomycin-induced mouse pulmonary fibrosis]. Bleomycin 32-41 cellular communication network factor 2 Mus musculus 24-28 19565505-6 2009 RESULTS: In the mouse lung tissue, CTGF expression and promoter activity peaked 1 week after bleomycin challenge, whereas type I collagen expression and Col1a2 promoter activity peaked 2 weeks postchallenge. Bleomycin 93-102 cellular communication network factor 2 Mus musculus 35-39 19565505-7 2009 Fibroblasts isolated from the mouse lungs 14 days after bleomycin treatment retained a profibrotic expression pattern, characterized by greatly elevated levels of type I collagen and CTGF protein and increased promoter activity. Bleomycin 56-65 cellular communication network factor 2 Mus musculus 183-187 19565505-9 2009 Moreover, in vivo, anti-CTGF antibodies applied after bleomycin challenge significantly reduced the Col1a2 promoter activity by approximately 25%. Bleomycin 54-63 cellular communication network factor 2 Mus musculus 24-28 19080365-6 2008 Moreover, simvastatin down-regulated the increased expression of transforming growth factor-beta1 (TGF-beta1) and connective tissue growth factor (CTGF) induced by bleomycin at both gene and protein levels. Bleomycin 164-173 cellular communication network factor 2 Mus musculus 114-145 19080365-6 2008 Moreover, simvastatin down-regulated the increased expression of transforming growth factor-beta1 (TGF-beta1) and connective tissue growth factor (CTGF) induced by bleomycin at both gene and protein levels. Bleomycin 164-173 cellular communication network factor 2 Mus musculus 147-151 19565505-3 2009 This study was undertaken to investigate the role of CTGF in enhanced expression of type I collagen in bleomycin-induced lung fibrosis, and to delineate the mechanisms of action underlying the effects of CTGF on Col1a2 (collagen gene type I alpha2) in this mouse model and in human pulmonary fibroblasts. Bleomycin 103-112 cellular communication network factor 2 Mus musculus 53-57 18201696-5 2008 METHODS: The regulation of CCN2 expression was examined in vivo in a model of fibrosis induced by bleomycin. Bleomycin 98-107 cellular communication network factor 2 Mus musculus 27-31 18201696-7 2008 RESULTS: Bleomycin-induced skin fibrosis in the mouse was associated with substantial CCN2 up-regulation in lesional fibroblasts. Bleomycin 9-18 cellular communication network factor 2 Mus musculus 86-90 15862142-1 2005 AIM: To investigate CTGF"s role in bleomycin-induced pulmonary fibrosis. Bleomycin 35-44 cellular communication network factor 2 Mus musculus 20-24 15256388-4 2004 We investigated if Balb/c mice, known to be fibrosis resistant partly due to lack of CTGF induction upon stimulation with bleomycin, can be transformed into fibrosis-sensitive individuals by generation of a CTGF-rich environment using transient overexpression of CTGF by adenoviral gene transfer (AdCTGF). Bleomycin 122-131 cellular communication network factor 2 Mus musculus 85-89 11491168-2 2001 Previous studies have shown that both CTGF messenger ribonuclear acid (mRNA) and protein are expressed in renal fibrosis and bleomycin-induced pulmonary fibrosis in mice. Bleomycin 125-134 cellular communication network factor 2 Mus musculus 38-42 12060566-3 2002 FR-167653 also inhibited augmented expression of tumor necrosis factor -alpha, connective tissue growth factor, and apoptosis of lung cells induced by bleomycin administration. Bleomycin 151-160 cellular communication network factor 2 Mus musculus 79-110 9700098-0 1998 Connective tissue growth factor mRNA expression is upregulated in bleomycin-induced lung fibrosis. Bleomycin 66-75 cellular communication network factor 2 Mus musculus 0-31 9700098-7 1998 CTGF mRNA expression was upregulated in the sensitive, but not in the resistant, mouse strain after administration of bleomycin. Bleomycin 118-127 cellular communication network factor 2 Mus musculus 0-4 34912332-9 2021 Also progesterone treatment decreased the gene expression of Col1a2 (P <0.05), Ctgf (P <01), End1 (0.001) in bleomycin- injured lung tissues. Bleomycin 109-118 cellular communication network factor 2 Mus musculus 79-83