PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31387171-4 2019 We found that angiotensin-converting enzyme 2 (ACE2) /Ang-(1-7)/MasR were decreased in the lungs of mice with IPF induced by bleomycin, and were negatively correlated with Tgfb1 mRNA expression. Bleomycin 125-134 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus 14-45 31387171-4 2019 We found that angiotensin-converting enzyme 2 (ACE2) /Ang-(1-7)/MasR were decreased in the lungs of mice with IPF induced by bleomycin, and were negatively correlated with Tgfb1 mRNA expression. Bleomycin 125-134 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus 47-51 25435005-4 2015 ACE2-uMSC injection following bleomycin pretreatment significantly alleviated lung injury in mice. Bleomycin 30-39 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus 0-4 29731719-5 2018 Although previous studies suggest that administration of ACE2 prevents PH secondary to bleomycin-induced murine IPF, it is unknown whether ACE2 can reverse or treat existing disease. Bleomycin 87-96 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus 57-61 27550926-2 2017 We evaluate the effects of pharmacological treatment with an angiotensin-converting enzyme 2 activator drug, associated with exercise, on the pulmonary lesions induced by bleomycin. Bleomycin 171-180 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus 61-92 28316159-6 2017 Wild type and ACE2 over-expressing mice were instilled with bleomycin endotracheally (3.5 mg/kg) or the same volume saline. Bleomycin 60-69 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus 14-18 28316159-16 2017 In bleomycin induced lung fibrosis in mice, ACE2(+ /+) -BLM mice exhibited milder lung fibrosis and lower NOX4 protein level but higher LC3-IIprotein level compared with WT-BLM mice. Bleomycin 3-12 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus 44-48 18441099-6 2008 In mice exposed to low doses of bleomycin, lung collagen accumulation was enhanced by intratracheal administration of either ACE-2-specific small interfering RNAs (siRNAs) or the peptide DX(600), a competitive inhibitor of ACE-2 (P<0.05). Bleomycin 32-41 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus 125-130 25998889-0 2015 Angiotensin-Converting Enzyme 2 Attenuates Bleomycin-Induced Lung Fibrosis in Mice. Bleomycin 43-52 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus 0-31 25998889-10 2015 RESULTS: Exogenous ACE2 attenuated bleomycin-induced lung fibrosis by reversing the reduction of local ACE2 and by suppressing the elevation of AGT. Bleomycin 35-44 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus 19-23 25998889-10 2015 RESULTS: Exogenous ACE2 attenuated bleomycin-induced lung fibrosis by reversing the reduction of local ACE2 and by suppressing the elevation of AGT. Bleomycin 35-44 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus 103-107 25998889-13 2015 CONCLUSION: ACE2 attenuated bleomycin-induced lung fibrosis as an anti-inflammatory anti-apoptotic and anti-fibrotic agent, and it might be a promising therapeutic target for IPF. Bleomycin 28-37 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus 12-16 22246130-0 2012 Angiotensin converting enzyme 2 abrogates bleomycin-induced lung injury. Bleomycin 42-51 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus 0-31 22246130-5 2012 We hypothesized that ACE2 prevents Bleomycin (BLM)-induced lung injury. Bleomycin 35-44 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus 21-25 22246130-5 2012 We hypothesized that ACE2 prevents Bleomycin (BLM)-induced lung injury. Bleomycin 46-49 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus 21-25 18441099-6 2008 In mice exposed to low doses of bleomycin, lung collagen accumulation was enhanced by intratracheal administration of either ACE-2-specific small interfering RNAs (siRNAs) or the peptide DX(600), a competitive inhibitor of ACE-2 (P<0.05). Bleomycin 32-41 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus 223-228 18441099-7 2008 Administration of either ACE-2 siRNA or DX(600) significantly increased the ANG II content of mouse lung tissue above the level induced by bleomycin alone. Bleomycin 139-148 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus 25-30