PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16187293-0	2006	Evidence for TGF-beta1 and bleomycin intracellular signaling through autocrine regulation of Smad 3 binding to the proximal promoter of the Smad 7 gene.	Bleomycin	27-36	SMAD family member 3	Homo sapiens	93-99	
16187293-4	2006	As demonstrated in this manuscript, Bleomycin"s intracellular signaling can be explained by a decrease of Smad 3 transcription factor binding to the SBE located in the proximal promoter of the inhibitory Smad 7 gene.	Bleomycin	36-45	SMAD family member 3	Homo sapiens	106-112	
27604640-7	2016	UCHL5, Smad2, and Smad3 levels were increased in bleomycin-injured lungs.	Bleomycin	49-58	SMAD family member 3	Homo sapiens	18-23	
12051713-0	2002	Regulation of Smad3 expression in bleomycin-induced pulmonary fibrosis: a negative feedback loop of TGF-beta signaling.	Bleomycin	34-43	SMAD family member 3	Homo sapiens	14-19	
12051713-4	2002	In this study, we investigated the expression of Smad2 and Smad3 in an in vivo animal model of lung fibrosis induced by bleomycin.	Bleomycin	120-129	SMAD family member 3	Homo sapiens	59-64	
12051713-5	2002	We found that the expression of Smad3 was regulated in lungs during bleomycin-induced pulmonary fibrosis.	Bleomycin	68-77	SMAD family member 3	Homo sapiens	32-37	
12051713-6	2002	The decline of Smad3 mRNA was evident at day three of post-bleomycin instillation and the expression of Smad3 continually decreased during the reparative phase of lung injury (days 8 and 12), whereas the expression of Smad2 showed little change after bleomycin administration.	Bleomycin	59-68	SMAD family member 3	Homo sapiens	15-20	
12051713-6	2002	The decline of Smad3 mRNA was evident at day three of post-bleomycin instillation and the expression of Smad3 continually decreased during the reparative phase of lung injury (days 8 and 12), whereas the expression of Smad2 showed little change after bleomycin administration.	Bleomycin	251-260	SMAD family member 3	Homo sapiens	104-109	
34506963-9	2022	Besides, TGF-beta/Smad3/miR-21 feedback loop signaling was upregulated in bleomycin-treated HUVEC and VM specimens, which was accompanied by increased collagen deposition.	Bleomycin	74-83	SMAD family member 3	Homo sapiens	18-23	
31331325-0	2019	Tenofovir alafenamide fumarate attenuates bleomycin-induced pulmonary fibrosis by upregulating the NS5ATP9 and TGF-beta1/Smad3 signaling pathway.	Bleomycin	42-51	SMAD family member 3	Homo sapiens	121-126	
29544542-8	2018	Additionally, HPH-15 suppressed the phosphorylation of Smad3 in various cells, including macrophages in the bleomycin-injected skin.	Bleomycin	108-117	SMAD family member 3	Homo sapiens	55-60	
27513632-0	2016	miR-221 targets HMGA2 to inhibit bleomycin-induced pulmonary fibrosis by regulating TGF-beta1/Smad3-induced EMT.	Bleomycin	33-42	SMAD family member 3	Homo sapiens	94-99