PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30347408-11	2018	In addition, oridonin could significantly inhibit BLM-induced upregulation of alpha-SMA and COL1A1 and the phosphorylation of Smad2/3 in lung tissues of mice.	Bleomycin	50-53	SMAD family member 2	Mus musculus	126-133	
23928001-0	2013	Long-term treatment with fasudil improves bleomycin-induced pulmonary fibrosis and pulmonary hypertension via inhibition of Smad2/3 phosphorylation.	Bleomycin	42-51	SMAD family member 2	Mus musculus	124-131	
23928001-12	2013	Fasudil inhibited the increased activity of RhoA/ROCK pathway, and partly altered bleomycin-associated activation of TGF-beta1/Smad pathway, via inhibition of Smad2/3 phosphorylation.	Bleomycin	82-91	SMAD family member 2	Mus musculus	159-166	
12839562-6	2003	Importantly, in bleomycin-injected skin, fibroblasts showed predominantly nuclear localization of Smad3 and intense staining for phospho-Smad2/3.	Bleomycin	16-25	SMAD family member 2	Mus musculus	137-142	
20581099-9	2011	Notably, Smad 2/3 signaling was of equal strength in WT and TSP-1 knockout mice treated with bleomycin, suggesting that TSP-1 is not required for the activation of TGF-beta.	Bleomycin	93-102	SMAD family member 2	Mus musculus	9-17	
23315259-8	2013	Knockdown of SphK1 or treatment with SphK inhibitor attenuated S1P generation and TGF-beta secretion in a bleomycin-induced lung fibrosis mouse model that was accompanied by reduced phosphorylation of Smad2 and MAPKs in lung tissue.	Bleomycin	106-115	SMAD family member 2	Mus musculus	201-206	
22398790-4	2012	In murine bleomycin-induced pulmonary fibrosis, nuclear localization of phosphorylated Smad2/3 (p-Smad2/3) was observed in pulmonary fibrotic lesions 7 days after bleomycin injection, whereas alpha-smooth muscle actin (ASMA)-positive myofibroblasts appeared in the lesions at 14 days, when the cytoplasmic localization of p-Smad2/3 was observed.	Bleomycin	10-19	SMAD family member 2	Mus musculus	98-105	
22398790-4	2012	In murine bleomycin-induced pulmonary fibrosis, nuclear localization of phosphorylated Smad2/3 (p-Smad2/3) was observed in pulmonary fibrotic lesions 7 days after bleomycin injection, whereas alpha-smooth muscle actin (ASMA)-positive myofibroblasts appeared in the lesions at 14 days, when the cytoplasmic localization of p-Smad2/3 was observed.	Bleomycin	163-172	SMAD family member 2	Mus musculus	98-105	
35355726-0	2022	ACPA Alleviates Bleomycin-Induced Pulmonary Fibrosis by Inhibiting TGF-beta-Smad2/3 Signaling-Mediated Lung Fibroblast Activation.	Bleomycin	16-25	SMAD family member 2	Mus musculus	76-83	
10393693-6	1999	In addition, we found that expression of Smad7 transgene blocked Smad2 phosphorylation induced by bleomycin in mouse lungs.	Bleomycin	98-107	SMAD family member 2	Mus musculus	65-70	
32528292-0	2020	Polyporus Polysaccharide Ameliorates Bleomycin-Induced Pulmonary Fibrosis by Suppressing Myofibroblast Differentiation via TGF-beta/Smad2/3 Pathway.	Bleomycin	37-46	SMAD family member 2	Mus musculus	132-139	
31775746-0	2019	Vitamin D deficiency exacerbates bleomycin-induced pulmonary fibrosis partially through aggravating TGF-beta/Smad2/3-mediated epithelial-mesenchymal transition.	Bleomycin	33-42	SMAD family member 2	Mus musculus	109-116	
31775746-20	2019	CONCLUSION: Vitamin D deficiency exacerbates BLM-induced pulmonary fibrosis partially through aggravating TGF-beta/Smad2/3-mediated EMT in the lungs.	Bleomycin	45-48	SMAD family member 2	Mus musculus	115-122	
31358001-13	2019	Finally, in mouse model of bleomycin-induced pulmonary fibrosis, therapeutic application of tannic acid resulted in a significant reduction of lung fibrosis, decrease in collagen-1 content and of Smad2 phosphorylation in the lungs.	Bleomycin	27-36	SMAD family member 2	Mus musculus	196-201	
30847938-0	2019	Mangiferin attenuates bleomycin-induced pulmonary fibrosis in mice through inhibiting TLR4/p65 and TGF-beta1/Smad2/3 pathway.	Bleomycin	22-31	SMAD family member 2	Mus musculus	109-116	
32808374-12	2020	Ogg1 knockout decreased the bleomycin-induced expression of Smad7 and phosphorylation of Smad2/3 in mice.	Bleomycin	28-37	SMAD family member 2	Mus musculus	89-96