PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17950632-0 2008 Role of carbohydrate moiety of bleomycin-A2 in caspase-3 activation and internucleosomal chromatin fragmentation in apoptosis of laryngeal carcinoma cells. Bleomycin 31-40 caspase 3 Homo sapiens 47-56 32103153-5 2020 Consistent with this finding, we showed that TSLP reduces caspase-1 and caspase-3 activity levels in primary human bronchial epithelial cells treated with bleomycin via Bcl-xL up-regulation. Bleomycin 155-164 caspase 3 Homo sapiens 72-81 23386420-7 2013 The concurrent incubation of NT2 cells with bleomycin/H2O2 and NAC (5 mM) for 24 h abolished bleomycin/H2O2-dependent increases in Caspase-3, -8, -9 activities, Bax and Cyt-c levels and bleomycin/H2O2-dependent decrease in Bcl-2 level. Bleomycin 44-53 caspase 3 Homo sapiens 131-148 23386420-7 2013 The concurrent incubation of NT2 cells with bleomycin/H2O2 and NAC (5 mM) for 24 h abolished bleomycin/H2O2-dependent increases in Caspase-3, -8, -9 activities, Bax and Cyt-c levels and bleomycin/H2O2-dependent decrease in Bcl-2 level. Bleomycin 93-102 caspase 3 Homo sapiens 131-148 23386420-7 2013 The concurrent incubation of NT2 cells with bleomycin/H2O2 and NAC (5 mM) for 24 h abolished bleomycin/H2O2-dependent increases in Caspase-3, -8, -9 activities, Bax and Cyt-c levels and bleomycin/H2O2-dependent decrease in Bcl-2 level. Bleomycin 93-102 caspase 3 Homo sapiens 131-148 22469952-7 2012 Curcumin (20 microM), bleomycin (400 microg/ml) and H2O2 (400 microM) incubation for 24 h decreased the viability of NTera-2 cells, and increased caspase-3, -8 and -9 activities, Bax and cytoplasmic cytochrome c levels and decreased Bcl-2 levels. Bleomycin 22-31 caspase 3 Homo sapiens 146-166 20154224-5 2010 Time course experiments revealed that bleomycin induced apoptosis within 4 h. Caspase-8, the initiator caspase for the extrinsic pathway, was activated within 2 h and preceded activation of the effector caspases-3 and -6 (4 h). Bleomycin 38-47 caspase 3 Homo sapiens 203-220 29735018-4 2018 Our current study revealed that a combination of bleomycin and AA significantly enhanced the expression of FAS gene, which is involved in programmed cell death (apoptosis) and caspases 3 and 8 compared to either bleomycin or AA alone implying that activation of extrinsic apoptotic pathway plays a major role in their (bleomycin + AA) tumoricidal action. Bleomycin 49-58 caspase 3 Homo sapiens 176-192 25173558-11 2015 Incubation of bleomycin alone caused a significant increase in caspase 3 activity in NCCIT. Bleomycin 14-23 caspase 3 Homo sapiens 63-72 25173558-12 2015 Combined incubation with bleomycin and TRAIL lead to elevated caspase 3 activity in Ntera-2. Bleomycin 25-34 caspase 3 Homo sapiens 62-71 23386420-6 2013 Incubation with bleomycin (LD50 ) and H2O2 for 24 h increased Caspase-3, -8, -9 activities, Cyt-c and Bax levels and decreased Bcl-2 levels. Bleomycin 16-25 caspase 3 Homo sapiens 62-79 22562160-8 2012 We found half of the lethal dose (LD(50)) of bleomycin on NCCIT cell viability as 120 mug/ml after incubation for 72 h. Incubation with bleomycin (LD(50)) induced increases in caspase-3, caspase-8, and caspase-9 activities and Cyt-c and Bax protein levels and a decrease in Bcl-2 level. Bleomycin 45-54 caspase 3 Homo sapiens 176-185 22562160-8 2012 We found half of the lethal dose (LD(50)) of bleomycin on NCCIT cell viability as 120 mug/ml after incubation for 72 h. Incubation with bleomycin (LD(50)) induced increases in caspase-3, caspase-8, and caspase-9 activities and Cyt-c and Bax protein levels and a decrease in Bcl-2 level. Bleomycin 136-145 caspase 3 Homo sapiens 176-185 22562160-9 2012 Co-incubation of NCCIT cells with bleomycin and 10 mM NAC abolished bleomycin-induced increases in caspase-3 and caspase-9 activities, Bax, and Cyt-c levels and bleomycin-induced decrease in Bcl-2 level. Bleomycin 34-43 caspase 3 Homo sapiens 99-108 22562160-9 2012 Co-incubation of NCCIT cells with bleomycin and 10 mM NAC abolished bleomycin-induced increases in caspase-3 and caspase-9 activities, Bax, and Cyt-c levels and bleomycin-induced decrease in Bcl-2 level. Bleomycin 68-77 caspase 3 Homo sapiens 99-108 22562160-9 2012 Co-incubation of NCCIT cells with bleomycin and 10 mM NAC abolished bleomycin-induced increases in caspase-3 and caspase-9 activities, Bax, and Cyt-c levels and bleomycin-induced decrease in Bcl-2 level. Bleomycin 68-77 caspase 3 Homo sapiens 99-108 22469952-8 2012 The concurrent use of curcumin with bleomycin induced caspase-3, -8 and -9 activities to a greater extent in NTera-2 cells than the use of each drug alone. Bleomycin 36-45 caspase 3 Homo sapiens 54-74 17031387-7 2006 The antitumour/proapoptotic effects of doxorubicin and bleomycin were assessed by cell proliferation and caspase-3 activity assay. Bleomycin 55-64 caspase 3 Homo sapiens 105-114 10463600-5 1999 The Ku-protein level and Ku DNA binding activity were decreased after treatment with bleomycin, adriamycin, or vincristine, and the decreases were blocked by the treatment of z-DEVD-fmk, a specific inhibitor of caspase-3, suggesting that loss of Ku DNA binding is, in part, due to a caspase-mediated decrease in Ku protein levels. Bleomycin 85-94 caspase 3 Homo sapiens 211-220 12573988-1 2003 Primary cultures of rat type II alveolar epithelial cells (AECs) or human AEC-derived A549 cells, when exposed to bleomycin (Bleo), exhibited concentration-dependent apoptosis detected by altered nuclear morphology, fragmentation of DNA, activation of caspase-3, and net cell loss over time. Bleomycin 114-123 caspase 3 Homo sapiens 252-261 12573988-1 2003 Primary cultures of rat type II alveolar epithelial cells (AECs) or human AEC-derived A549 cells, when exposed to bleomycin (Bleo), exhibited concentration-dependent apoptosis detected by altered nuclear morphology, fragmentation of DNA, activation of caspase-3, and net cell loss over time. Bleomycin 125-129 caspase 3 Homo sapiens 252-261