PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23570914-0 2013 Suppression of nuclear factor erythroid 2-related factor 2 via extracellular signal-regulated kinase contributes to bleomycin-induced oxidative stress and fibrogenesis. Bleomycin 116-125 nuclear factor, erythroid derived 2, like 2 Mus musculus 15-58 24637114-4 2014 Using an in vivo bleomycin-induced lung fibrosis model, we reveal a clock "gated" pulmonary response to oxidative injury, with a more severe fibrotic effect when bleomycin was applied at a circadian nadir in NRF2 levels. Bleomycin 17-26 nuclear factor, erythroid derived 2, like 2 Mus musculus 208-212 24637114-4 2014 Using an in vivo bleomycin-induced lung fibrosis model, we reveal a clock "gated" pulmonary response to oxidative injury, with a more severe fibrotic effect when bleomycin was applied at a circadian nadir in NRF2 levels. Bleomycin 162-171 nuclear factor, erythroid derived 2, like 2 Mus musculus 208-212 23570914-3 2013 Treatment of C57 BL/6 mice with bleomycin increased fibroblast viability and collagen production and significantly downregulated Nrf2. Bleomycin 32-41 nuclear factor, erythroid derived 2, like 2 Mus musculus 129-133 23570914-5 2013 In a cell-based model, bleomycin suppressed Nrf2 activation via extracellular signal-related kinase phosphorylation, enhancing intracellular reactive oxygen species in lung fibroblasts and stimulating abnormal cell proliferation and collagen secretion. Bleomycin 23-32 nuclear factor, erythroid derived 2, like 2 Mus musculus 44-48 23570914-6 2013 To confirm this novel mechanism of bleomycin-induced fibrogenesis, we attempted to upregulate Nrf2 and related antioxidant proteins in bleomycin-treated fibroblasts using a putative Nrf2 activator, caffeic acid phenethyl ester, and the results showed that bleomycin-induced fibroblast proliferation and collagen content were attenuated through improved redox balance. Bleomycin 35-44 nuclear factor, erythroid derived 2, like 2 Mus musculus 94-98 23570914-6 2013 To confirm this novel mechanism of bleomycin-induced fibrogenesis, we attempted to upregulate Nrf2 and related antioxidant proteins in bleomycin-treated fibroblasts using a putative Nrf2 activator, caffeic acid phenethyl ester, and the results showed that bleomycin-induced fibroblast proliferation and collagen content were attenuated through improved redox balance. Bleomycin 35-44 nuclear factor, erythroid derived 2, like 2 Mus musculus 182-186 23570914-6 2013 To confirm this novel mechanism of bleomycin-induced fibrogenesis, we attempted to upregulate Nrf2 and related antioxidant proteins in bleomycin-treated fibroblasts using a putative Nrf2 activator, caffeic acid phenethyl ester, and the results showed that bleomycin-induced fibroblast proliferation and collagen content were attenuated through improved redox balance. Bleomycin 135-144 nuclear factor, erythroid derived 2, like 2 Mus musculus 94-98 23570914-6 2013 To confirm this novel mechanism of bleomycin-induced fibrogenesis, we attempted to upregulate Nrf2 and related antioxidant proteins in bleomycin-treated fibroblasts using a putative Nrf2 activator, caffeic acid phenethyl ester, and the results showed that bleomycin-induced fibroblast proliferation and collagen content were attenuated through improved redox balance. Bleomycin 135-144 nuclear factor, erythroid derived 2, like 2 Mus musculus 182-186 23570914-6 2013 To confirm this novel mechanism of bleomycin-induced fibrogenesis, we attempted to upregulate Nrf2 and related antioxidant proteins in bleomycin-treated fibroblasts using a putative Nrf2 activator, caffeic acid phenethyl ester, and the results showed that bleomycin-induced fibroblast proliferation and collagen content were attenuated through improved redox balance. Bleomycin 135-144 nuclear factor, erythroid derived 2, like 2 Mus musculus 94-98 23570914-6 2013 To confirm this novel mechanism of bleomycin-induced fibrogenesis, we attempted to upregulate Nrf2 and related antioxidant proteins in bleomycin-treated fibroblasts using a putative Nrf2 activator, caffeic acid phenethyl ester, and the results showed that bleomycin-induced fibroblast proliferation and collagen content were attenuated through improved redox balance. Bleomycin 135-144 nuclear factor, erythroid derived 2, like 2 Mus musculus 182-186 33027868-0 2020 The Effects of Chronic Intermittent Hypoxia in Bleomycin-induced lung injury on Pulmonary Fibrosis via Regulating the NF-kappaB/Nrf2 Signaling Pathway. Bleomycin 47-56 nuclear factor, erythroid derived 2, like 2 Mus musculus 128-132 34148362-7 2021 HDAC3 and FOXM1 inducibly bound to Nrf2 promoter locus containing the motif in lung tissues of bleomycin mice, accompanied by reduced local histone3 acetylation, which were relieved by RGFP966. Bleomycin 95-104 nuclear factor, erythroid derived 2, like 2 Mus musculus 35-39 15208274-5 2004 Bleomycin-induced increases in lung weight, epithelial cell death, and inflammation were significantly greater in Nrf2-/- mice than in Nrf2+/+ mice. Bleomycin 0-9 nuclear factor, erythroid derived 2, like 2 Mus musculus 114-118 15208274-5 2004 Bleomycin-induced increases in lung weight, epithelial cell death, and inflammation were significantly greater in Nrf2-/- mice than in Nrf2+/+ mice. Bleomycin 0-9 nuclear factor, erythroid derived 2, like 2 Mus musculus 135-139 15208274-6 2004 Indices of lung fibrosis (hydroxyproline content, collagen accumulation, fibrotic score, cell proliferation) were significantly greater in bleomycin-treated Nrf2-/- mice, compared with Nrf2+/+ mice. Bleomycin 139-148 nuclear factor, erythroid derived 2, like 2 Mus musculus 157-161 15208274-7 2004 NRF2 expression and activity were elevated in Nrf2+/+ mice by bleomycin. Bleomycin 62-71 nuclear factor, erythroid derived 2, like 2 Mus musculus 0-4 15208274-7 2004 NRF2 expression and activity were elevated in Nrf2+/+ mice by bleomycin. Bleomycin 62-71 nuclear factor, erythroid derived 2, like 2 Mus musculus 46-50 15208274-8 2004 Bleomycin caused greater up-regulation of several NRF2-inducible antioxidant enzyme genes and protein products in Nrf2+/+ mice compared with Nrf2-/- mice. Bleomycin 0-9 nuclear factor, erythroid derived 2, like 2 Mus musculus 50-54 15208274-8 2004 Bleomycin caused greater up-regulation of several NRF2-inducible antioxidant enzyme genes and protein products in Nrf2+/+ mice compared with Nrf2-/- mice. Bleomycin 0-9 nuclear factor, erythroid derived 2, like 2 Mus musculus 114-118 15208274-9 2004 Further, bleomycin-induced transcripts and protein levels of lung injury and fibrosis markers were significantly attenuated in Nrf2+/+ mice compared with Nrf2-/- mice. Bleomycin 9-18 nuclear factor, erythroid derived 2, like 2 Mus musculus 127-131 15208274-9 2004 Further, bleomycin-induced transcripts and protein levels of lung injury and fibrosis markers were significantly attenuated in Nrf2+/+ mice compared with Nrf2-/- mice. Bleomycin 9-18 nuclear factor, erythroid derived 2, like 2 Mus musculus 154-158 32349726-5 2020 Therefore, the aim of the present study was to investigate if the dietary antioxidant quercetin can exert anti-fibrotic effects in a mouse model of bleomycin-induced pulmonary fibrogenesis through Nrf2-dependent restoration of redox imbalance. Bleomycin 148-157 nuclear factor, erythroid derived 2, like 2 Mus musculus 197-201 32349726-12 2020 CONCLUSION: Quercetin exerts anti-fibrogenic and anti-inflammatory effects on bleomycin-induced pulmonary damage in mice possibly through modulation of the redox balance by inducing Nrf2. Bleomycin 78-87 nuclear factor, erythroid derived 2, like 2 Mus musculus 182-186 29864937-8 2018 At the same time, FGF21 also markedly reversed the activity of SOD and T-AOC, decreased the enhanced content of MDA and increased the expression of Nrf-2 in the lungs of BLM-treated mice. Bleomycin 170-173 nuclear factor, erythroid derived 2, like 2 Mus musculus 148-153 31364255-8 2020 MSC inhibited BiP expression in bleomycin-induced ER stress, attenuating ER stress via the protein kinase RNA-like ER kinase (PERK)-Nrf2 pathway. Bleomycin 32-41 nuclear factor, erythroid derived 2, like 2 Mus musculus 132-136 31364255-10 2020 CONCLUSION: Our data suggest that MSC operate on ER stress via several pathways, but the PERK-Nrf2 pathway revealed to be the main functioning pathway in our bleomycin model. Bleomycin 158-167 nuclear factor, erythroid derived 2, like 2 Mus musculus 94-98 30370641-5 2019 Bleomycin (BLM)-induced PF in Nrf2-knockout (Nrf2-/- ) and wild-type (WT) mice and transforming growth factor beta1 (TGF-beta1)-induced EMT in rat type II alveolar epithelial cell line (RLE-6TN) and human alveolar epithelial cell line (A549) were established to observe the relationship among Nrf2, HMGB1, and EMT by western blot and immunohistochemistry. Bleomycin 0-9 nuclear factor, erythroid derived 2, like 2 Mus musculus 30-34 30370641-5 2019 Bleomycin (BLM)-induced PF in Nrf2-knockout (Nrf2-/- ) and wild-type (WT) mice and transforming growth factor beta1 (TGF-beta1)-induced EMT in rat type II alveolar epithelial cell line (RLE-6TN) and human alveolar epithelial cell line (A549) were established to observe the relationship among Nrf2, HMGB1, and EMT by western blot and immunohistochemistry. Bleomycin 0-9 nuclear factor, erythroid derived 2, like 2 Mus musculus 45-49 30370641-5 2019 Bleomycin (BLM)-induced PF in Nrf2-knockout (Nrf2-/- ) and wild-type (WT) mice and transforming growth factor beta1 (TGF-beta1)-induced EMT in rat type II alveolar epithelial cell line (RLE-6TN) and human alveolar epithelial cell line (A549) were established to observe the relationship among Nrf2, HMGB1, and EMT by western blot and immunohistochemistry. Bleomycin 11-14 nuclear factor, erythroid derived 2, like 2 Mus musculus 30-34 30370641-5 2019 Bleomycin (BLM)-induced PF in Nrf2-knockout (Nrf2-/- ) and wild-type (WT) mice and transforming growth factor beta1 (TGF-beta1)-induced EMT in rat type II alveolar epithelial cell line (RLE-6TN) and human alveolar epithelial cell line (A549) were established to observe the relationship among Nrf2, HMGB1, and EMT by western blot and immunohistochemistry. Bleomycin 11-14 nuclear factor, erythroid derived 2, like 2 Mus musculus 45-49 32032580-7 2020 In the present study, bleomycin (BLM)-induced skin fibrosis model was applied to keratinocyte-specific Nrf2 knockout (Nrf2(K)-KO) mice generated with Keratin 14-Cre/loxp system. Bleomycin 22-31 nuclear factor, erythroid derived 2, like 2 Mus musculus 103-107 32032580-7 2020 In the present study, bleomycin (BLM)-induced skin fibrosis model was applied to keratinocyte-specific Nrf2 knockout (Nrf2(K)-KO) mice generated with Keratin 14-Cre/loxp system. Bleomycin 33-36 nuclear factor, erythroid derived 2, like 2 Mus musculus 103-107 32032580-8 2020 BLM treatment significantly suppressed Nrf2 expression in the epidermis. Bleomycin 0-3 nuclear factor, erythroid derived 2, like 2 Mus musculus 39-43 29362432-5 2018 Here, we observed the effects of Nrf2 pathway and Numb on bleomycin(BLM)-induced PF in Nrf2-knockout (Nrf2-/-) and wild-type (WT) mice. Bleomycin 58-67 nuclear factor, erythroid derived 2, like 2 Mus musculus 87-91 29362432-5 2018 Here, we observed the effects of Nrf2 pathway and Numb on bleomycin(BLM)-induced PF in Nrf2-knockout (Nrf2-/-) and wild-type (WT) mice. Bleomycin 58-67 nuclear factor, erythroid derived 2, like 2 Mus musculus 87-91 29362432-5 2018 Here, we observed the effects of Nrf2 pathway and Numb on bleomycin(BLM)-induced PF in Nrf2-knockout (Nrf2-/-) and wild-type (WT) mice. Bleomycin 68-71 nuclear factor, erythroid derived 2, like 2 Mus musculus 87-91 29362432-5 2018 Here, we observed the effects of Nrf2 pathway and Numb on bleomycin(BLM)-induced PF in Nrf2-knockout (Nrf2-/-) and wild-type (WT) mice. Bleomycin 68-71 nuclear factor, erythroid derived 2, like 2 Mus musculus 87-91 29362432-7 2018 We found BLM-induced lung fibrosis were more severe in Nrf2-/- mice compared to WT mice with reduced expressions of HO-1 and NQO1. Bleomycin 9-12 nuclear factor, erythroid derived 2, like 2 Mus musculus 55-59 28420366-0 2017 Pirfenidone attenuates bleomycin-induced pulmonary fibrosis in mice by regulating Nrf2/Bach1 equilibrium. Bleomycin 23-32 nuclear factor, erythroid derived 2, like 2 Mus musculus 82-86 28487960-0 2017 Sulforaphane prevents bleomycin-induced pulmonary fibrosis in mice by inhibiting oxidative stress via nuclear factor erythroid 2-related factor-2 activation. Bleomycin 22-31 nuclear factor, erythroid derived 2, like 2 Mus musculus 102-145 28027929-5 2017 Bleomycin treatment of Nrf2-null mice resulted in exaggerated fibrosis. Bleomycin 0-9 nuclear factor, erythroid derived 2, like 2 Mus musculus 23-27 28304344-0 2017 Nrf2 Regulates the Risk of a Diesel Exhaust Inhalation-Induced Immune Response during Bleomycin Lung Injury and Fibrosis in Mice. Bleomycin 86-95 nuclear factor, erythroid derived 2, like 2 Mus musculus 0-4 27982105-5 2016 Here, bleomycin (BLM) was intratracheally injected into both Nrf2-knockout (Nrf2-/-) and wild-type mice to compare the development of PF. Bleomycin 6-15 nuclear factor, erythroid derived 2, like 2 Mus musculus 61-65 27982105-7 2016 We found that BLM-induced EMT and lung fibrosis were more severe in Nrf2-/- mice compared to wild-type mice. Bleomycin 14-17 nuclear factor, erythroid derived 2, like 2 Mus musculus 68-72