PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31100425-12 2019 Treatment with MSC-MVs significantly inhibited BLM-induced apoptosis and fibrosis in lung tissues and PI3K/AKT/mTOR activation, which was reversed by HGF mRNA deficient MVs. Bleomycin 47-50 hepatocyte growth factor Homo sapiens 150-153 22744972-2 2012 Human HGF, which was expressed specifically by alveolar epithelial type II cells after gene transfer, attenuated the bleomycin-induced pulmonary fibrosis in an animal model. Bleomycin 117-126 hepatocyte growth factor Homo sapiens 6-9 17056705-0 2007 Gene transfer of hepatocyte growth factor by electroporation reduces bleomycin-induced lung fibrosis. Bleomycin 69-78 hepatocyte growth factor Homo sapiens 17-41 17056705-7 2007 Electroporation-mediated in vivo HGF gene transfer using pCikhHGF 7 days after intratracheal bleomycin reduced pulmonary fibrosis as assessed by histology and hydroxyproline determination 14 days after bleomycin compared with controls treated with the same vector not containing the HGF sequence (pCik). Bleomycin 93-102 hepatocyte growth factor Homo sapiens 33-36 17056705-7 2007 Electroporation-mediated in vivo HGF gene transfer using pCikhHGF 7 days after intratracheal bleomycin reduced pulmonary fibrosis as assessed by histology and hydroxyproline determination 14 days after bleomycin compared with controls treated with the same vector not containing the HGF sequence (pCik). Bleomycin 93-102 hepatocyte growth factor Homo sapiens 62-65 17056705-7 2007 Electroporation-mediated in vivo HGF gene transfer using pCikhHGF 7 days after intratracheal bleomycin reduced pulmonary fibrosis as assessed by histology and hydroxyproline determination 14 days after bleomycin compared with controls treated with the same vector not containing the HGF sequence (pCik). Bleomycin 202-211 hepatocyte growth factor Homo sapiens 33-36 17056705-7 2007 Electroporation-mediated in vivo HGF gene transfer using pCikhHGF 7 days after intratracheal bleomycin reduced pulmonary fibrosis as assessed by histology and hydroxyproline determination 14 days after bleomycin compared with controls treated with the same vector not containing the HGF sequence (pCik). Bleomycin 202-211 hepatocyte growth factor Homo sapiens 62-65 17056705-10 2007 In conclusion, electroporation-mediated gene transfer of hHGF decreases bleomycin-induced pulmonary fibrosis, possibly by increasing alveolar epithelial cell proliferation and reducing apoptosis, resulting in improved alveolar wound repair. Bleomycin 72-81 hepatocyte growth factor Homo sapiens 57-61 15963921-1 2005 We examined therapeutic gene transfer of human hepatocyte growth factor (hHGF) to alveolar septa in mouse bleomycin-induced lung fibrosis using macroaggregated albumin-polyethylenimine complex (MAA-PEI). Bleomycin 106-115 hepatocyte growth factor Homo sapiens 47-71 15963921-1 2005 We examined therapeutic gene transfer of human hepatocyte growth factor (hHGF) to alveolar septa in mouse bleomycin-induced lung fibrosis using macroaggregated albumin-polyethylenimine complex (MAA-PEI). Bleomycin 106-115 hepatocyte growth factor Homo sapiens 73-77 15963921-3 2005 The exogenous source of hHGF gene expression increased the endogenous mouse HGF in the lungs and significantly decreased TNF-alpha, IL-6, and collagen synthesis after bleomycin injury. Bleomycin 167-176 hepatocyte growth factor Homo sapiens 24-28 22441736-0 2012 Apoptotic cell instillation after bleomycin attenuates lung injury through hepatocyte growth factor induction. Bleomycin 34-43 hepatocyte growth factor Homo sapiens 75-99 22441736-4 2012 We investigated the direct effect of in vivo exposure to apoptotic cells in bleomycin-stimulated lungs (2 days old) on HGF induction. Bleomycin 76-85 hepatocyte growth factor Homo sapiens 119-122 22441736-5 2012 Furthermore, sequential changes of bleomycin-induced HGF production following apoptotic cell instillation related to the changes in inflammatory and fibrotic responses were assessed. Bleomycin 35-44 hepatocyte growth factor Homo sapiens 53-56 22441736-6 2012 At 2 h after apoptotic cell instillation into bleomycin-stimulated lungs, the levels of HGF mRNA and protein production, and apoptotic cell clearance by alveolar macrophages were enhanced. Bleomycin 46-55 hepatocyte growth factor Homo sapiens 88-91 22441736-7 2012 Furthermore, HGF induction persistently increased following apoptotic cell instillation up to 21 days after bleomycin treatment. Bleomycin 108-117 hepatocyte growth factor Homo sapiens 13-16 22441736-11 2012 These findings indicate that in vivo exposure to apoptotic cells enhances transcriptional HGF production in bleomycin-stimulated lungs, resulting in attenuation of lung injury and fibrosis. Bleomycin 108-117 hepatocyte growth factor Homo sapiens 90-93 17825173-15 2007 CONCLUSIONS: Injection of the plasmid pcDNA3.1-hHGF into skeletal muscle with electroporation has a potential role in the treatment of bleomycin-induced lung fibrosis. Bleomycin 135-144 hepatocyte growth factor Homo sapiens 47-51 14712301-3 2004 (In this study, working with a bleomycin(BLM)-induced scleroderma model mice, we performed two transfections of human hepatocyte growth factor (HGF) cDNA into the skeletal muscle and showed that this treatment not only helped to prevent the dermal sclerosis simultaneously injected BLM but also improved the symptoms of dermal sclerosis induced by BLM 4 weeks previously.) Bleomycin 31-40 hepatocyte growth factor Homo sapiens 118-142 14712301-3 2004 (In this study, working with a bleomycin(BLM)-induced scleroderma model mice, we performed two transfections of human hepatocyte growth factor (HGF) cDNA into the skeletal muscle and showed that this treatment not only helped to prevent the dermal sclerosis simultaneously injected BLM but also improved the symptoms of dermal sclerosis induced by BLM 4 weeks previously.) Bleomycin 31-40 hepatocyte growth factor Homo sapiens 144-147 14712301-3 2004 (In this study, working with a bleomycin(BLM)-induced scleroderma model mice, we performed two transfections of human hepatocyte growth factor (HGF) cDNA into the skeletal muscle and showed that this treatment not only helped to prevent the dermal sclerosis simultaneously injected BLM but also improved the symptoms of dermal sclerosis induced by BLM 4 weeks previously.) Bleomycin 41-44 hepatocyte growth factor Homo sapiens 118-142 14712301-3 2004 (In this study, working with a bleomycin(BLM)-induced scleroderma model mice, we performed two transfections of human hepatocyte growth factor (HGF) cDNA into the skeletal muscle and showed that this treatment not only helped to prevent the dermal sclerosis simultaneously injected BLM but also improved the symptoms of dermal sclerosis induced by BLM 4 weeks previously.) Bleomycin 41-44 hepatocyte growth factor Homo sapiens 144-147