PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8635193-0 1995 Restoration of interleukin-2 production in tumor-bearing rats through reducing tumor-derived transforming growth factor beta by treatment with bleomycin. Bleomycin 143-152 interleukin 2 Rattus norvegicus 15-28 8635193-7 1995 In vitro experiments also showed that TGF beta activity, mRNA expression, and protein synthesis in KDH-8 tumor cells were reduced by bleomycin treatment, and that bleomycin-treated-KDH-8-tumor-cell-conditioned medium did not inhibit IL-2 production from normal rat splenocytes. Bleomycin 133-142 interleukin 2 Rattus norvegicus 233-237 8635193-7 1995 In vitro experiments also showed that TGF beta activity, mRNA expression, and protein synthesis in KDH-8 tumor cells were reduced by bleomycin treatment, and that bleomycin-treated-KDH-8-tumor-cell-conditioned medium did not inhibit IL-2 production from normal rat splenocytes. Bleomycin 163-172 interleukin 2 Rattus norvegicus 233-237 8635193-8 1995 These results suggest that bleomycin treatment restored IL-2 production in tumor-bearing rats through reducing the tumor-derived TGF beta. Bleomycin 27-36 interleukin 2 Rattus norvegicus 56-60 7683934-5 1993 Administration of BLM, 5 mg/kg, on day 8, restored IL-2 and IL-6 production and significantly increased TNF production by day 14 of tumor burden as compared with the amounts of cytokine produced by the mitogen-stimulated untreated tumor-bearing rat spleen cells. Bleomycin 18-21 interleukin 2 Rattus norvegicus 51-55 2429940-0 1986 Potentiation of release of interleukin-2 by bleomycin. Bleomycin 44-53 interleukin 2 Rattus norvegicus 27-40 2445487-0 1987 Enhancement of interleukin-2 release in rats by treatment with bleomycin and adriamycin in vivo. Bleomycin 63-72 interleukin 2 Rattus norvegicus 15-28 2445487-1 1987 Spleen cells from rats previously injected with bleomycin (10 mg/kg) or Adriamycin (1 mg/kg) were able to release higher levels of interleukin-2 (IL-2) than cells from untreated animals. Bleomycin 48-57 interleukin 2 Rattus norvegicus 131-144 2445487-1 1987 Spleen cells from rats previously injected with bleomycin (10 mg/kg) or Adriamycin (1 mg/kg) were able to release higher levels of interleukin-2 (IL-2) than cells from untreated animals. Bleomycin 48-57 interleukin 2 Rattus norvegicus 146-150 2429940-1 1986 The antineoplastic drug bleomycin, which has not been shown to have immunosuppressive activity, was tested for its effect on concanavalin A-induced interleukin-2 production. Bleomycin 24-33 interleukin 2 Rattus norvegicus 148-161 2429940-3 1986 However, using a suboptimal dose of concanavalin A, bleomycin increased interleukin-2 release significantly. Bleomycin 52-61 interleukin 2 Rattus norvegicus 72-85 2429940-7 1986 It is suggested that bleomycin, and probably other cytotoxic drugs, may modulate the immune response through its effects on the release of immunostimulating cytokines such as interleukin-1 and -2. Bleomycin 21-30 interleukin 2 Rattus norvegicus 175-195